Clinical Remission of Classic Kaposi Sarcoma with Topical 5% Imiquimod

Echeverría-García, B.; Sanmartín, O.; Guillén, C.

doi:10.1016/s1578-2190(10)70609-0

Cited by 5 publications

(6 citation statements)

References 7 publications

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“…It has been found to be highly effective against KS in some case reports in the literature. [9][10][11][12][13][14][15][16][17] There is only 1 trial wherein imiquimod in KS was investigated for its antitumour activity, showing antitumour activity in 8 of 17 patients. 2 Our study is designed to evaluate the effect of imiquimod, which is distinguished from other local treatment methods by its at-home application, on classic KS lesions compared with cryotherapy, which is one of the most-used treatment methods for KS in our department.…”

Section: Introductionmentioning

confidence: 99%

Imiquimod 5% Cream Versus Cryotherapy in Classic Kaposi Sarcoma

et al. 2019

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Background: Classic Kaposi sarcoma usually remains on the skin and has a slow progression; thus, local treatment methods are preferable. Imiquimod is an immunomodulatory agent with antiviral, antitumoural, and antiangiogenic properties that is expedient against Kaposi sarcoma. Objectives: We aimed to clarify whether imiquimod is effective on classic Kaposi sarcoma lesions by comparing imiquimod treatment with cryotherapy, which is the most-used treatment method in our department for this disease. Method: Patients with classic Kaposi sarcoma were included. All lesions of each patient were evaluated and measured by the blinded investigator considering infiltration and surface diameters. Then, lesions were categorized into 2 groups by the other investigator (nonblinded), and imiquimod 5% cream was administered 3 times per week without occlusion in 1 group. Cryotherapy was performed every 3 weeks in the other group. All lesions were reevaluated and measured at the end of 12 weeks by the blinded investigator. Initial and last measurements were compared between the treatment methods. Results: Fifty lesions of 8 patients were included in this study. Imiquimod and cryotherapy were applied to 26 and 24 lesions, respectively. At the end of the study, statistically significant decreases were detected in all scores between weeks 0 and 12 with both treatment methods. Mean percentages of change in scores were not significantly different between the methods. Conclusions: Based on a limited number of patients and lesions treated, we believe imiquimod may be a suitable option to use for the treatment of classic Kaposi sarcoma.

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Section: Introductionmentioning

confidence: 99%

Imiquimod 5% Cream Versus Cryotherapy in Classic Kaposi Sarcoma

et al. 2019

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“…Systemic treatments with vinblastine, bleomycin, doxorubicin, etoposide, or intralesional interferon alpha have been used, besides cryotherapy, laser or photodynamic therapy. 1,2 Topical imiquimod is a ligand of the Toll-like receptors 7 and 8 on dendritic cells, and it functions as an immune …”

Section: Discussionmentioning

confidence: 99%

“…8 Recently a 72-year-old man with multiple, small papules on the right foot was treated with 5% imiquimod cream on alternate days and complete healing was achieved at 10 weeks. 1 In another case report, an 87-year-old man with widespread lesions on both legs was treated with 5% imiquimod cream with complete response. This patient experienced flu-like symptoms with every day applications, the symptoms disappeared by reducing the applications to every other day.…”

Section: 23mentioning

confidence: 99%

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Efficacy of 5% imiquimod cream in a patient with classic Kaposi sarcoma

Gündüz¹,

Günay²,

İnanır³

et al. 2012

J Dermatol Case Rep

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Background: The classic Kaposi sarcoma is most common in the Mediterranean population over 50 years of age and presents with reddish-brown papules and nodules particularly on the lower limbs. Treatment depends on the clinical presentation and extension of lesions. Imiquimod is as an immune response modifier with antiangiogenic activity. Main observations:We present a 74-year-old man with classic Kaposi sarcoma who had multiple, small, violaceous papules and nodules on the trunk and extremities with a history of 14 years. He complained particularly from plantar hyperkeratotic painful nodules. Treatment with imiquimod 5% cream under occlusion resulted with almost complete regression within 12 weeks. No local or systemic side effects were observed. Conclusions:Topical imiquimod was a safe and effective therapy in our patient with

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“…In classic Kaposi sarcoma, treatment must be individualized and includes nonintervention, 2 radiotherapy, surgery, topical imiquimod, 3 cryotherapy, laser, photodynamic therapy and antiviral drugs or, if extensive skin or mucosal lesions are present, liposomal doxorubicin or other chemotherapeutic agents. 4 The classic form of Kaposi sarcoma usually has an indolent course and a good prognosis, with few deaths directly attributable to the condition itself.…”

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confidence: 99%