Clinical relevance of urokinase‐type plasminogen activator and its inhibitor type 1 (PAI‐1) in squamous cell carcinoma of the uterine cervix

Abstract

The results indicate, that PAI-1 expression is of some prognostic impact in cervical cancer, indicating an association of elevated PAI levels with local tumour progression and reduced recurrence-free survival.

Prognostic relevance of TGF‐β1 and PAI‐1 in cervical cancer

“…Because all the patients in their group were of a FIGO stage II disease, comparisons between stages could not be made, nor was the relationship with other parameters evaluated. In another study by Horn et al .,38 PAI‐1 expression in 114 cervical cancer patients (FIGO stage I to III) was evaluated and, corresponding with our study, elevated PAI‐1 levels were demonstrated to be positively correlated with advanced tumor stage. However, after including other prognostic parameters in their multivariate analysis, PAI‐1 failed to give additional prognostic information regarding survival rates, which is in contrast to our findings.…”

“…Overproduction of both factors has been associated with poor survival in a large variety of cancers 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38. Data on the role of these 2 factors in cervical carcinogenesis are conflicting.…”

“…Studies on the significance of TGF‐β 1 as a clinical prognostic parameter for survival and relapse or the relationship with other established prognostic parameters contradict each other, too 39, 40, 41, 42, 43, 44, 45, 46, 47. Although there seems to be an association between increasing PAI‐1 expression and malignant transformation of cervical epithelium, literature on the prognostic consequence of PAI‐1 in cervical cancer is scarce and conflicting 38, 48…”

Polymorphisms in the Genes Related to Angiogenesis Are Associated With Uterine Cervical Cancer

“…The overproduction of both factors has been associated with a worse prognosis in a broad variety of cancer diseases. 27,28 Within this report, the PAI-1-TGF-A1 genes in the group of patients showed a high LD value (71%, P G 0.001).…”

Alpinia pricei Rhizome Extracts Induce Cell Cycle Arrest in Human Squamous Carcinoma KB Cells and Suppress Tumor Growth in Nude Mice

“…There is increasing evidence for PAI in cancer metastasis independent of its protease inhibitory activity, such as tumor cell motility, cell and anti-cell adhesion, pro- and anti-angiogenesis, and prevention of apoptosis [37]. In cervical cancer, increased levels of uPA and PAI-1 proteins were detected in cervical tumor extracts but not in normal tissue extracts [38] and are linked to poor prognosis [39]. In this study, we revealed that AP extracts decreased protein levels of tumor metastasis-related proteins such as MMP-9 and u-PA in KB cells.…”