Clinical relevance of thyroid-stimulating immunoglobulin as a biomarker of the activity of thyroid eye disease

Jeon, Hansol; Lee, Joo Yeon; Kim, Yu Jeong; Lee, Min Joung

doi:10.1038/s41433-022-01981-z

Cited by 10 publications

(14 citation statements)

References 30 publications

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“…The level of antibodies to thyroid-stimulating hormone receptors is statistically significantly higher in moderately severe endocrine ophthalmopathy 21.6 IU/l in comparison with mild endocrine ophthalmopathy 12.9 IU/l (p=0.001), which corresponds to the results of most researchers [6,10,12,13,14].…”

Section: Results Of the Research And Discussionsupporting

confidence: 84%

“…The levels of antibodies to thyroid-stimulating hormone receptors were significantly higher in men compared to female patients in both the first and second groups, p = 0.049 and p = 0.038 respectively, which is confirmed in the works of other authors [9,10].…”

Section: Results Of the Research And Discussionsupporting

confidence: 79%

“…The titer of antibodies to thyroid-stimulating hormone receptors positively correlated with the degree of activity of endocrine ophthalmopathy (r = 0.41). Our results do not contradict the studies of domestic and foreign scientists [6,10,11,12].…”

Section: Results Of the Research And Discussionsupporting

confidence: 70%

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Clinical Significance of Antibodies to Thyrotropic Hormone Receptor as a Biomarker of Graves Disease Activity

Tsurkan¹,

Lushchik²,

Makeeva³

2022

EJNH

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Objective: to study the clinical significance of antibodies to thyroid-stimulating hormone receptors as a biomarker of Graves' disease activity in patients in the Voronezh region. A retrospective study of 76 patients with Graves' disease treated at Voronezh Regional Clinical Hospital #1 from 2018 to 2021 was carried out. Qualitative and quantitative indicators were assessed: anamnestic data, features of the clinical picture, the results of laboratory and instrumental research methods at the first visit, in 6 and 12 months after antithyroid therapy. During the study, 3 groups were formed: group 1 -patients with Graves' disease -35 people, group 2 -patients with Graves' disease in combination with previously untreated endocrine ophthalmopathy -41 people, group 3 -control group of 15 people without thyroid disease. Our study found that male gender, smoking, free triiodothyronine levels, the severity of thyrotoxicosis and the presence of endocrine ophthalmopathy had a positive correlation with high levels of antibodies to thyroid-stimulating hormone receptors. Measurement of the level of antibodies to thyroid-stimulating hormone receptors in the blood in patients with Graves' disease helps to assess the course of Graves' disease complicated by endocrine ophthalmopathy and allows to determine the risk of activity and severity of endocrine ophthalmopathy. Determining the level of antibodies to thyroid-stimulating hormone receptors is recommended not only for rapid diagnosis, differential diagnosis, but also for monitoring the adequacy of treatment of patients with Graves' disease.

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Section: Results Of the Research And Discussionsupporting

confidence: 84%

Section: Results Of the Research And Discussionsupporting

confidence: 79%

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Clinical Significance of Antibodies to Thyrotropic Hormone Receptor as a Biomarker of Graves Disease Activity

Tsurkan¹,

Lushchik²,

Makeeva³

2022

EJNH

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“…CAS is widely accepted as the gold standard method for assessing TED activity 5,6,34 . The TSI assay has been reported to correlate with TED activity 35 . However, there is no standardized method for the detection of TSI and most techniques are intended for the qualitative detection of TSI, rather than a quantitative test.…”

Section: Environmental Information Processingmentioning

confidence: 99%

Serum microRNA as a potential biomarker for the activity of thyroid eye disease

Kim

Choung

Kim

et al. 2023

Sci Rep

Self Cite

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The aim of this study is to characterize the microRNA (miRNA) expression signatures in patients with thyroid eye disease (TED) and identify miRNA biomarkers of disease activity. Total RNA was isolated from the sera of patients with TED (n = 10) and healthy controls (HCs, n = 5) using the miRNeasy Serum/Plasma Kit. The NanoString assay was used for the comprehensive analysis of 798 miRNA expression profiles. Analysis of specific miRNA signatures, mRNA target pathway analysis, and network analysis were performed. Patients with TED were divided into two groups according to disease activity: active and inactive TED groups. Differentially expressed circulating miRNAs were identified and tested using quantitative reverse transcription-polymerase chain reaction (qRT-PCR) tests in the validation cohort. Among the 798 miRNAs analyzed, 173 differentially downregulated miRNAs were identified in TED patients compared to those in the HCs. Ten circulating miRNAs were differentially expressed between the active and inactive TED groups and regarded as candidate biomarkers for TED activity (one upregulated miRNA: miR-29c-3p; nine downregulated miRNAs: miR-4286, miR-941, miR-571, miR-129-2-3p, miR-484, miR-192-5p, miR-502-3p, miR-597-5p, and miR-296-3p). In the validation cohort, miR-484 and miR-192-5p showed significantly lower expression in the active TED group than in the inactive TED group. In conclusion, the expression levels of miR-484 and miR-192-5p differed significantly between the active and inactive TED groups, suggesting that these miRNAs could serve as circulating biomarkers of TED activity, however, these findings need to be validated in further studies.

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“…Helper T cells interact with B cells and secrete cytokines such as interleukin-2 and interferon-γ, which cause B cells to differentiate into plasma cells that secrete antithyrotropinreceptor antibodies. 16,35 These antibodies stimulate the thyrotropin receptor on thyroid follicular epithelial cells and increase production of thyroid hormone. Antithyrotropin-receptor antibodies also recognize thyrotropin receptors on orbital fibroblasts and, in conjunction with the secreted type 1 helper T cytokines interferon-γ and tumor necrosis factor, initiate tissue changes characteristic of TED.…”

Section: Tbiimentioning

confidence: 99%