Clinical relevance of three subtypes of primary sinonasal lymphoma characterized by immunophenotypic analysis

Kim, Gwi Eon; Koom, Woong Sub; Yang, Woo Ick; Lee, Sang Wook; Keum, Ki Chang; Lee, Chang Geol; Suh, Chang‐Ok; Hahn, Jae Won; Roh, Jae Kyung; Kim, Joo Hang

doi:10.1002/hed.20015

Cited by 61 publications

(52 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, peripheral T cell lymphoma and NK/T cell lymphoma mostly occurred in the nasal cavity. Our results are in agreement with the finding of a previous study showing that the nasal cavity is more frequently the site of T cell and NK/T cell lymphoma, whereas sinus involvement without nasal disease is common in B-cell lymphoma [28]. Our patients with T cell lymphoma were mostly diagnosed as having stage I disease, while patients with B cell lymphoma were often diagnosed at late stage (84.6% stage I in NK/T cell, 91.7% stage I in peripheral T vs. 28.6% stage I in B cell).…”

Section: Discussionsupporting

confidence: 96%

The diagnosis of sinonasal lymphoma: a challenge for rhinologists

Yen

Wang

Jiang

et al. 2011

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

The presenting symptoms of sinonasal lymphoma are usually similar to those of benign inflammatory diseases. Adequate amount of biopsy tissue is required for a definitive diagnosis because tumor coexisting with necrosis or inflammation is not uncommon. Therefore, the diagnosis of sinonasal lymphoma is a challenge for rhinologists. Thirty-two patients diagnosed as having sinonasal lymphoma from 1990 to 2010 in our hospital were included in this study. The presenting symptoms of these patients included nasal obstruction, rhinorrhea, bloody discharge/epistaxis, post nasal drip, facial swelling, neck mass, orbital symptoms, fever, and body weight loss. The average period between patients' awareness of their symptoms and their decision to seek medical help was 8.9 months. When they were referred to our hospital, the first impression of 20 patients (62.5%) was benign or malignant nasal neoplasm, and that of the other 12 patients (37.5%) was rhinitis or rhinosinusitis. These patients then received image studies and biopsy or surgical intervention. Most patients needed repeated biopsies, endoscopic sinus surgery, turbinectomy, or Caldwell-Luc operation for a definitive diagnosis. Their histopathologic classification included NK/T cell lymphoma (n = 13, 40.6%), peripheral T cell lymphoma (n = 12, 37.5%), and diffuse large B cell lymphoma (n = 7, 21.9%). Peripheral T cell lymphoma and NK/T cell lymphoma mostly occurred in the nasal cavity, whereas sinus involvement without nasal disease is common in B-cell lymphoma Our results reveal that patients with sinonasal NHL tend to ignore their symptoms until they become serious, and a definitive diagnosis usually requires repeat and deep biopsy.

show abstract

Section: Discussionsupporting

confidence: 96%

The diagnosis of sinonasal lymphoma: a challenge for rhinologists

Yen

Wang

Jiang

et al. 2011

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…Recently, studies with large numbers of patients showed that the prognosis of nasal NK-cell lymphoma is significantly poorer than that of nasal 'T-cell' lymphoma [29,46]. Differential diagnosis of NK-cell lymphoma from genuine T-cell lymphoma may therefore be required in the future.…”

Section: Immunophenotype Of Extranodal Nk-cell Lymphoma Nasal Typementioning

confidence: 99%

Extranodal NK/T‐cell lymphoma: diagnosis and treatment cues

Suzuki

Takeuchi

Ohshima

et al. 2008

Hematological Oncology

134

130

View full text Add to dashboard Cite

Extranodal NK/T-cell lymphoma, nasal type (ENKL) is mostly endemic to East Asia. It predominantly occurs in the nasal or paranasal areas and less frequently in the skin. Most of the tumours show NK-cell, but rarely T-cell, phenotypes. The Epstein-Barr virus (EBV) genome can be usually detected in lymphoma cells. Geographic localization of ENKL matches the endemic distribution of EBV, suggesting that EBV plays an important role in lymphomagenesis. Originally, NK-cell and T-cell types were believed to present the same clinicopathologic characteristics, but recent data suggest more aggressive characteristics for the NK-cell phenotype. Although ENKL is sensitive to radiotherapy, it shows a poorer response to chemotherapeutic agents than other lymphomas due to expression of p-glycoprotein. Therefore, new therapeutic approaches must be considered. Several new clinical trials are now being conducted in East Asia.

show abstract

“…Previous studies have reported that T-cell and natural killer/ T-cell lymphomas mainly occur in the nasal cavity, whereas B-cell lymphomas commonly occur in the sinus without nasal disease (10,11). Clinically aggressive lymphomas, including Burkitt's lymphoma and diffuse large B-cell lymphoma of the sphenoid sinus, exhibit atypical characteristics, including destruction of adjacent bone such as the skull base and infiltration of the dura mater with intracranial invasion (12).…”

Section: Discussionmentioning

confidence: 99%

Primary non-Hodgkin lymphoma of the sphenoid sinus with visual disturbance: A report of two cases

Gong

Yang

et al. 2016

Oncology Letters

View full text Add to dashboard Cite

Abstract. Primary non-Hodgkin lymphoma (PNHL) of the sphenoid sinus is a rare neoplasm that poses a diagnostic challenge to clinicians. The proximity of the optical nerve and canal to the sphenoid sinus is accountable for the high incidence of visual disturbance in PNHL of the sphenoid sinus. In particular, patients whose radiologic diagnosis reveals bone destruction in the lateral wall involved with optical-nerve-canals or cavernous sinus present a high risk of rapidly developing unilateral blindness. The present study reports 2 rare cases of PNHL of the sphenoid sinus. Sudden sight loss may follow minimally invasive biopsy. In such cases, the measures that must be taken for the prevention of permanent sight loss are limited in the absence of the final pathologic diagnosis.

show abstract

Clinical relevance of three subtypes of primary sinonasal lymphoma characterized by immunophenotypic analysis

Cited by 61 publications

References 32 publications

The diagnosis of sinonasal lymphoma: a challenge for rhinologists

The diagnosis of sinonasal lymphoma: a challenge for rhinologists

Extranodal NK/T‐cell lymphoma: diagnosis and treatment cues

Primary non-Hodgkin lymphoma of the sphenoid sinus with visual disturbance: A report of two cases

Contact Info

Product

Resources

About