Clinical relevance of the fibrinogen uptake test in patients undergoing elective general abdominal surgery—relation to major thromboembolism and mortality

Flordal, Per Anders; Bergqvist, David; Ljungström, Karl-Gösta; Törngren, S

doi:10.1016/0049-3848(95)00204-9

Cited by 28 publications

(22 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…17) Flordal et al reported that long hospital stay was independent predictor for major thromboembolism. 18) From the study results reported by Gibbs and Flordal et al, 17,18) long term bed rest was shown as a moderate risk for VTE in Japanese prevention guideline. 14) ACCP guideline showed that favored strategy for diagnosis of first DVT was combine use of pretest probability assessment, D-dimer, and ultrasonography.…”

Section: Resultsmentioning

confidence: 99%

Occurrence of Deep Vein Thrombosis among Hospitalized Non-Surgical Japanese Patients

Yamada

Hanzawa

Ota

et al. 2015

Annals of Vascular Diseases

View full text Add to dashboard Cite

Objective: To estimate the frequency of deep vein thrombosis (DVT) among non-surgical inpatients, and to evaluate the D-dimer assay as a screening tool for DVT. Methods: Subjects were non-surgical inpatients aged 20 years or older who had been bedridden for at least 24 hours and had moderate-to-high risk factors for DVT. We assessed the presence of DVT by venous ultrasonography. Patients who received a diagnosis of venous thromboembolism (VTE) before admission, who had symptoms or findings of VTE at admission, or who had surgery or trauma within the past 3 months before admission were excluded. Results: DVT was confirmed in 96 of 525 patients (18.3%). In a logistic regression analysis, longer duration of hospitalization, higher D-dimer value, and history of cancer surgery were significantly associated with the occurrence of DVT. The D-dimer assay showed high sensitivity (96.1%) and high negative predictive value (97.6%). Conclusion: Non-surgical inpatients with a long-term hospitalization or history of cancer surgery have a risk for DVT, and need to be considered for added DVT preventive measures as recommended in the prevention guidelines. In addition, the D-dimer assay is beneficial for the screening of DVT in medical practice.

show abstract

Section: Resultsmentioning

confidence: 99%

Occurrence of Deep Vein Thrombosis among Hospitalized Non-Surgical Japanese Patients

Yamada

Hanzawa

Ota

et al. 2015

Annals of Vascular Diseases

View full text Add to dashboard Cite

show abstract

“…27 The risk of progression of postoperative venous thrombosis appears to be greater if the initial thrombosis is large, and if there are continuing risk factors for thrombosis (eg, immobilization). 21,26,28 The risk of symptomatic VTE is generally highest within 2 wk of surgery, and remains elevated for about 2 to 3 mo. 3,5,18,[29][30][31] Without prophylaxis, the highest risk period for fatal postoperative PE appears to be approximately 3 to 7 d following surgery.…”

Section: Retrospective Epidemiologic Studymentioning

confidence: 99%

Duration of Venous Thromboembolism Prophylaxis After Surgery

Kearon

2003

Chest

111

View full text Add to dashboard Cite

“…2,8,9 The risk of progression of postoperative VTE is greater when there are continuing risk factors for thrombosis (eg, immobilization) and when the initial thrombosis is large. 2,9,128 The risk of VTE differs with type of surgery: major orthopedic surgery is associated with about twice the risk of VTE associated with major general surgery. 15,129,130 75% of DVT after orthopedic surgery occur in the operated leg.…”

Section: Natural History Of Treated Vte Resolution Of Dvt With Anticomentioning

confidence: 99%

Natural History of Venous Thromboembolism

2003

View full text Add to dashboard Cite

Abstract-Most deep vein thromboses (DVTs) start in the calf, and most probably resolve spontaneously. Thrombi that remain confined to the calf rarely cause leg symptoms or symptomatic pulmonary embolism (PE). The probability that calf DVT will extend to involve the proximal veins and subsequently cause PE increases with the severity of the initiating prothrombotic stimulus. Although acute venous thromboembolism (VTE) usually presents with either leg or pulmonary symptoms, most patients have thrombosis at both sites at the time of diagnosis. Proximal DVTs resolve slowly during treatment with anticoagulants, and thrombi remain detectable in half of the patients after a year. Resolution of DVT is less likely in patients with a large initial thrombus or cancer. About 10% of patients with symptomatic DVTs develop severe post-thrombotic syndrome within 5 years, and recurrent ipsilateral DVT increases this risk. About 10% of PEs are rapidly fatal, and an additional 5% cause death later, despite diagnosis and treatment. About 50% of diagnosed PEs are associated with right ventricular dysfunction, which is associated with a Ϸ5-fold greater in-hospital mortality. There is Ϸ50% resolution of PE after 1 month of treatment, and perfusion eventually returns to normal in two thirds of patients. About 5% of treated patients with PE develop pulmonary hypertension as a result of poor resolution. After a course of treatment, the risk of recurrent thrombosis is higher (ie, Ϸ10% per patient-year) in patients without reversible risk factors, in those with cancer, and in those with prothrombotic biochemical abnormalities such as antiphospholipid antibodies and homozygous factor V Leiden.

show abstract

Clinical relevance of the fibrinogen uptake test in patients undergoing elective general abdominal surgery—relation to major thromboembolism and mortality

Cited by 28 publications

References 18 publications

Occurrence of Deep Vein Thrombosis among Hospitalized Non-Surgical Japanese Patients

Occurrence of Deep Vein Thrombosis among Hospitalized Non-Surgical Japanese Patients

Duration of Venous Thromboembolism Prophylaxis After Surgery

Natural History of Venous Thromboembolism

Contact Info

Product

Resources

About