Clinical Relevance of the Advanced Microbiologic and Biochemical Investigations in Periodontal Diagnosis: A Critical Analysis

Grover, Vishakha; Kapoor, Anoop; Malhotra, Ranjan; Kaur, Gagandeep

doi:10.1155/2014/785615

Cited by 6 publications

(2 citation statements)

References 113 publications

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“…The biomarkers that have been examined in relation to PoC test kits ( Table 3 ) have been shown to identify the severity of periodontal diseases [ 54 , 140 , 152 ]. However, apart from PerioSafe ® and ImplantSafe ® , none of these tests have demonstrated the prognostic capabilities of importance to both clinician and patient.…”

Section: Periodontal Point-of-care Test Kitsmentioning

confidence: 99%

Diagnostic Accuracy of Oral Fluids Biomarker Profile to Determine the Current and Future Status of Periodontal and Peri-Implant Diseases

et al. 2020

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Severe periodontitis is ranked as the sixth most prevalent disease affecting humankind, with an estimated 740 million people affected worldwide. The diagnosis of periodontal diseases mainly relies upon assessment of conventional clinical parameters. However, these parameters reflect past, rather than current, clinical status or future disease progression and, likely, outcome of periodontal treatment. Specific and sensitive biomarkers for periodontal diseases have been examined widely to address these issues and some biomarkers have been translated as point-of-care (PoC) tests. The aim of this review was to provide an update on PoC tests for use in the diagnosis and management of periodontal diseases. Among the PoC tests developed so far, active matrix metalloproteinase-8 has shown promising results in terms of diagnostic and prognostic values. However, further studies are required to increase the sensitivity and specificity via combining more than one biomarker and merging these test kits with periodontal risk assessment tools. Furthermore, the validity of these test kits needs to be investigated by applying the results in further independent studies and the impact on these test kits’, together with the results of risk factors for periodontal diseases, such as diabetes and smoking, also needs to be examined.

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Section: Periodontal Point-of-care Test Kitsmentioning

confidence: 99%

Diagnostic Accuracy of Oral Fluids Biomarker Profile to Determine the Current and Future Status of Periodontal and Peri-Implant Diseases

et al. 2020

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“…However, a periodontal diagnostic tool provides the disease characteristics such as pocket depths, bleeding on probing, clinical attachment levels, plaque index, and alveolar bone level, which can be confirmed with radiographic imaging. Those are appropriate for differential diagnosis, disease location, and severity of infection [25]. Besides, cross-sectional observation is not able to give more detail information about the causal relationship between poor oral health and physical fitness [12].…”

Section: Strengths and Limitations Of The Reviewmentioning

confidence: 99%

The impact of oral health on physical fitness: A systematic review

Bramantoro

Hariyani

Setyowati

et al. 2020

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Background: Oral health problems may have numerous effects on general health, including physical fitness and performance. In this review, we aimed to systematically review the available evidence to assess the effect of oral health on general physical fitness. Methods: We systematically performed a literature search in two different databases (PUBMED and EMBASE) without restriction to the year of publication. Articles were included if the subjects were humans and the primary aim was to assess the effects of dental and/or oral health problems on physical activity using either objective physical measurements or physical performance tests. The quality of the studies was then assessed using a Joanna Briggs Institute (JBI) Critical Appraisal tool. Results: A total of 2651 articles were initially retrieved from the systematic search of the literature. Of these, a final total of 11 articles following the inclusion criteria were included in the review. All of the 11 articles included in the review had good methodological quality. Of the 11 articles, ten articles suggested a correlation between dental and oral condition toward physical fitness, body balance, cardiorespiratory function, and also cognitive function. Only one article found contradictory results, which showed that periodontal conditions did not correlate with the cardiorespiratory function. Malocclusion, including the number of remaining teeth, was reported in five studies (45.4%), periodontal disease was evaluated in six studies (54.5%), along with slight evaluation of periapical inflammation. Conclusion: This review suggests that there is a negative effect of poor dental and/or oral health on physical fitness and performance.

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