Clinical Relevance of Selenium with Liver Stiffness and Steatosis Detected by Transient Elastography in Adults

Liu, Xiaohui; Shen, Hong; Chen, Mingfeng; Shao, Jun

doi:10.1007/s12011-021-02912-x

Cited by 7 publications

(4 citation statements)

References 38 publications

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“…These studies consistently indicated an inverse association of dietary selenium intake with stroke occurrence, whereas excessive selenium intake had no additional protective effect. Indeed, excessive selenium intake/exposure may lead to selenium toxicity and is associated with adverse health outcomes, such as positive associations with the prevalence of non-alcoholic fatty liver disease and type 2 diabetes [23,24]. Our study obtained similar ndings, providing new evidence for the prognostic value of dietary selenium intake in stroke patients.…”

Section: Discussionsupporting

confidence: 73%

Nonlinear associations of dietary selenium intake with all-cause and cardiovascular mortality after stroke in US adults: findings from NHANES 1999-2018

Deng,

Du,

Tao

et al. 2024

Preprint

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Background: The association between dietary selenium intake and mortality in stroke patients remains unclear. We aimed to explore these associations through NHANES 1999-2018. Methods: Stroke participants ≥20 years of age were enrolled and were followed until December 31, 2019. Dietary selenium intake and stroke diagnosis were obtained by self-report on the questionnaire. Mortality information was obtained through prospective matching with the National Death Index database. Results: 1334 stroke survivors were included. Dietary selenium intake was significantly and inversely associated with all-cause mortality in stroke patients after adjusting for all confounders (hazard ratio [HR]=0.997, p=0.024). Compared to the reference population, stroke patients with dietary selenium intake in quartiles Q2, Q3, and Q4 were associated with reduced all-cause mortality (p for trend=0.02). Dietary selenium intake at Q2 was associated with reduced CVD mortality after stroke and not significantly associated with cancer mortality. Restricted cubic spline analysis indicated that dietary selenium intake was nonlinearly associated with all-cause (p for nonlinear=0.0361) and CVD mortality (p for nonlinear=0.0189) in stroke patients. Segmented regression showed that dietary selenium intake was inversely associated with all-cause and CVD mortality at <81 mcg/d and 87 mcg/d, respectively, with no additional protective effects thereafter. Stratified analyses suggested that these effects were only present in specific ages and genders. Conclusions: In a national longitudinal cohort, dietary selenium intake was nonlinearly associated with all-cause and CVD mortality but not cancer mortality after stroke in U.S. adults. Dietary selenium intake at 81 mcg/d and 87 mcg/d had the optimal protective effect on post-stroke all-cause and CVD mortality, respectively.

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Section: Discussionsupporting

confidence: 73%

Nonlinear associations of dietary selenium intake with all-cause and cardiovascular mortality after stroke in US adults: findings from NHANES 1999-2018

Deng,

Du,

Tao

et al. 2024

Preprint

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“…Liver cirrhosis and steatosis, which may be caused by obesity, were shown to be positively correlated with increased dietary selenium intake and blood selenium concentrations by Liu. et al ( 36 ). Furthermore, multiple studies have revealed a link between dietary selenium intake and blood selenium levels and an increased risk of type 2 diabetes in diverse groups ( 37–39 ).…”

Section: Discussionmentioning

confidence: 98%

Associations of dietary antioxidant micronutrients with the prevalence of obesity in adults

Yang

Xu²,

Zhang³

et al. 2023

Front. Nutr.

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BackgroundAntioxidant micronutrients have a therapeutic potential for clinical treatment of obesity. NO research, however, has examined the connection between the complex level of dietary antioxidants and obesity.Materials and methodsWe mainly aimed to investigate the relationship between a combination of antioxidants and obesity using the database of the national health and nutrition examination survey (NHANES). This cross-sectional study contains a survey of 41,021 people (≥18 years) in total ranging from 2005 to 2018. Multivariate logistic and weighted quantile sum (WQS) regression were performed to investigate the associations between these antioxidants, both individually and collectively, and the prevalence of obesity. The restricted cubic spline (RCS) regression was also utilized to analyze the linearity of these associations.ResultsAccording to multivariate logistic models, we found that the levels of most antioxidants in the highest quartile were independently related to a lower prevalence of obesity, while a reverse result was observed in selenium (p for trend <0.05). The WQS index revealed that a total of the 11 antioxidants is negatively related to the prevalence of obesity and abdominal obesity (all p<0.001), and iron/vitamin C have the greatest weight in the negative associations between antioxidant complex and obesity, as well as abdominal obesity. In addition, the RCS regression showed that retinol, vitamin A, α-carotene, β-carotene, β-cryptoxanthin, vitamin C, iron, and copper all had a non-linear association with obesity. Threshold effect analysis demonstrated that the inflection points of retinol, vitamin A, α-carotene, β-carotene, β-cryptoxanthin, vitamin C, iron, and cooper were 235.57, 374.81, 58.89, 891.44, 30.70, 43,410.00, 11,240.00, and 990.00 μg/day, respectively.ConclusionOur study found that a high level of a complex of 11 dietary antioxidants is related to a lower prevalence of obesity and abdominal obesity, among this inverse associations iron and vitamin C have the greatest weight.

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“…A systematic review incorporating several studies with different conclusions suggested that selenium intake seemed to be unrelated to MetS in adults ( Retondario et al, 2019 ). In fact, several studies using NHANES have shown that selenium intake is positively associated with the prevalence of other metabolic disorders including NAFLD ( Cardoso et al, 2021 , Deng and Tan, 2022 , Liu et al, 2022 ). This may indicate that selenium itself is not deficient among U.S. adults and that excessive selenium intake contributes to selenium toxicity.…”

Section: Discussionmentioning

confidence: 99%

Composite dietary antioxidant index is associated with reduced prevalence of metabolic syndrome but not mortality in metabolic syndrome: Results from NHANES 2001–2018

Clinical Relevance of Selenium with Liver Stiffness and Steatosis Detected by Transient Elastography in Adults

Cited by 7 publications

References 38 publications

Nonlinear associations of dietary selenium intake with all-cause and cardiovascular mortality after stroke in US adults: findings from NHANES 1999-2018

Nonlinear associations of dietary selenium intake with all-cause and cardiovascular mortality after stroke in US adults: findings from NHANES 1999-2018

Associations of dietary antioxidant micronutrients with the prevalence of obesity in adults

Composite dietary antioxidant index is associated with reduced prevalence of metabolic syndrome but not mortality in metabolic syndrome: Results from NHANES 2001–2018

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