Clinical Relevance of Preoperative Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratio in Renal Cell Carcinoma

Abstract

Objective: The association of preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with postoperative tumor stage and Fuhrman nuclear grade was investigated in patients with renal cell carcinoma (RCC). Materials and Methods: Data of 123 patients, who were operated due to RCC, in our clinic was analysed. NLR and PLR were evaluated in patients who were classified according to tumor stage (T1 and T2 low stage, T3 and T4 high stage) and Fuhrman nuclear grade (grade 1 and 2 low-grade, grade 3 and 4 high-grade). NLR and PLR were compared using Levene's test between the groups. Results: Sixty four patients were female (52.1%) and 59 were male (47.9%). All haematological parameters were expressed as 10 3 /μL. Mean age, blood neutrophil, lymphocyte and platelet counts, and NLR and PLR values of the patients were 62.49±12.43 years, 6.27±2.8, 2.05±0.83, 263.72±89.03, 4.01±3.93, and 149.73±82.1, respectively. The most common histologic subtype was recorded as clear cell RCC (76.4%). NLR and PLR were 3.83±3.22 and 142.79±66.66, respectively in the low-stage group and 4.43±5.29 and 165.85±109.41, respectively in the high stage group. As for the Fuhrman nuclear grading, NLR and PLR were 3.81±3.45 and 146.63±87.36, respectively in the low-grade group and 4.61±5.387 and 159.32±63.42 in the high-grade group. There was no statistically significant difference between the groups (p>0.05). Conclusion: Although not statistically significant, high tumor stage and nuclear grade were positively correlated with NLR and PLR. It is concluded that, further multi-center and prospective studies with larger samples are needed to derive meaningful results.

Clinical significance of pretreatment De Ritis ratio in renal cell carcinoma

“…In fact, many different prognostic markers have been analyzed in previous studies in the literature. 1 Anatomic prognostic factors include tumor size, venous invasion, capsule invasion, microvascular invasion, lymphovascular invasion, renal sinus fat invasion, perinefric fat invasion, adrenal involvement, lymph node, and distant metastasis. Histologic subgroup, sarcomatoid/ rhabdoid transformation, nuclear grade, tumor necrosis, microvascular invasion, and collecting system invasion are evaluated for histopathological prognostic parameters.…”

“…Pathological T stage, histological subtypes, Fuhrman nuclear grade of tissue samples were analyzed. 1,[14][15][16] Surgical specimens were assessed for tumor grades and stage using the Fuhrman system and 2018 TNM classification respectively. 14 The De Ritis ratio, calculated by dividing AST by ALT.…”

“…According to histopathological analyses, 80-85% of all renal tumors were composed of renal cell carcinomas (RCC). 1 RCCs are more frequently observed in industrial societies and many factors such as obesity, hypertension, and smoking are blamed in the etiology. It is 1.5 times more common in males than in females, with a significant increase in the incidence of diagnosis in the 6th and 7th decades of life.…”

“…6 However, despite all these developments, RCC remains the most mortal urologic malignancy. 1 Therefore, the molecular biological character of RCC is important in developing an optimal treatment strategy against recurrent diseases and determining follow-up protocols. For this reason, it is very important to investigate prognostic markers in RCC patients.…”

Sarkomatoid renal hücreli karsinom: olgu sunumu ve literatürün gözden geçirilmesi

“…Renal hücreli karsinom (RHK) tüm böbrek kanserlerin %85'ini oluşturmaktadır (3). Son yıllarda üroradyoloji alanındaki teknolojik yenilikler ve birçok merkezde görüntüleme yöntemlerinin yaygın olarak kullanımı ile bağlantılı olarak her evrede RHK görülme oranında belirgin bir artış izlenmektedir (4). Bu malign oluşumlar oldukça mortal seyirili olup olguların 1/3'ü tanı anında metastatiktir.…”