1985
DOI: 10.1016/0090-4295(85)90158-x
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Clinical relevance of plasma testosterone and prolactin changes in advanced cancer of prostate treated with diethylstilbestrol or estramustine phosphate

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Cited by 18 publications
(7 citation statements)
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“…This is in accordance with most previous reports in this field [1,3,4,7,10]. Adlercreutz et al [1] found a significant asso ciation between a low pretreatment testosterone/PRL ratio and a poor prognosis.…”
Section: Discussionsupporting
confidence: 82%
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“…This is in accordance with most previous reports in this field [1,3,4,7,10]. Adlercreutz et al [1] found a significant asso ciation between a low pretreatment testosterone/PRL ratio and a poor prognosis.…”
Section: Discussionsupporting
confidence: 82%
“…Similar results have recently been reported by Bishop et al [4] during CAP treatment with diethylstilbestrol or estramustin phosphate. These results are at variance with those of Mee et al [9] and Morales and Nickel [10], who reported significant asso ciations between high PRL level during endocrine treat ment and a poor prognosis. However, in the study of Mee et al [9] the patients were not randomized, results from several forms of mixed treatment with or without hyperprolactinemia-inducing drugs were combined, and even untreated patients were included.…”
Section: Discussioncontrasting
confidence: 57%
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“…The general finding is that low-to-moderate levels of Prl potentiate the trophic effects of testosterone on prostatic growth but that, beyond optimal levels, the lactogen becomes an inhibitor of both normal and neoplastic growth. These relationships have clinical significance since there is an inverse relationship between survival and serum prolactin levels in prostatic cancer patients [ 1,2], and stabilization or remission of the disease has been found to follow prolactin depletion [3,4].…”
Section: Introductionmentioning
confidence: 97%