Clinical relevance of narrow-band imaging in flexible cystoscopy: the DaBlaCa-7 study

Drejer, Ditte; Beji, Sami; Nielsen, Anne Ellerup; Høyer, Søren; Lam, Gitte Wrist; Jensen, Jørgen Bjerggaard

doi:10.1080/21681805.2017.1295101

Cited by 17 publications

(12 citation statements)

References 17 publications

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“…A multicenter study published by Drejer et al [ 23 ] in 2017 showed that NBI had higher sensitivity than WLC, and changed the relevant clinical decision in 18 cases (1.9%). In this study, 1 additional cancer (CIS) was detected using NBI in 1 patient (1.18%, 1/85).…”

Section: Discussionmentioning

confidence: 99%

Detection and recurrence rate of transurethral resection of bladder tumors by narrow-band imaging: Prospective, randomized comparison with white light cystoscopy

et al. 2018

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PurposeThe purpose of this study was to evaluate the efficacy of narrow-band imaging (NBI) as a diagnostic tool for detecting bladder tumors during cystoscopy compared with white light cystoscopy (WLC).Materials and MethodsFrom December 2013 to June 2017, a randomized prospective study was conducted on 198 patients underwent transurethral resection of bladder tumor by a single surgeon. The patients were divided into two groups according to diagnostic method. In Group I, WLC only was performed. In Group II, NBI was additionally performed after WLC. We analyzed the rate of detection of bladder tumors as a primary endpoint. In addition, we evaluated rates of recurrence in each group.ResultsThere were no significant differences between the two groups in characteristics except hypertension. In the analysis of rates of detection, the probability of diagnosing cancer was 80.9% (114/141) in the WLC group, and the probability of diagnosing cancer using WLC in the NBI group was 85.5% (159/186). After switching from WLC to NBI for second-look cystoscopy in the NBI group, NBI was shown to detect additional tumors with a detection rate of 35.1% (13/37) from the perspective of the patients and 42.2% (27/64) from the perspective of the tumors. The 1-year recurrence-free rate was 72.2% in the WLC group and 85.2% in the NBI group (p=0.3).ConclusionsNBI had benefits for detecting tumors overlooked by WLC. Although the difference in the 1-year recurrence-free rate was not statistically significant, our results showed a trend for higher recurrence in the NBI group.

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Section: Discussionmentioning

confidence: 99%

Detection and recurrence rate of transurethral resection of bladder tumors by narrow-band imaging: Prospective, randomized comparison with white light cystoscopy

et al. 2018

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“…Narrow Band Imaging (NBI) verschärft den Kontrast zwischen hypervaskularisiertem Gewebe (im Regelfall Tumor) zur normalen Blasenschleimhaut. Eine verbesserte Detektion im Vergleich zur WL-Zystoskopie konnte sowohl für die flexible Zystoskopie als auch für die TUR‑B gezeigt werden [ 29 , 30 , 31 , 32 ]. Eine verringerte Rezidivrate bestätigte sich nur für die Subgruppe der Low-risk-Tumoren nach 3 und 12 Monaten [ 33 ].…”

Section: Erweiterte Techniken Der Tumorvisualisierungunclassified

Transurethrale Resektion von Blasentumoren (TUR-B)

Oswald

Pallauf

Herrmann

et al. 2022

Urologe

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ZusammenfassungDie transurethrale Resektion von Blasengewebe (TUR-B) ist für die Diagnostik und Therapie bei Blasentumoren indiziert. Diese werden fragmentiert mittels diathermaler Schlinge abgetragen. Der Wundgrund wird zur Blutstillung koaguliert. Zu achten ist auf eine ausreichende Schnitttiefe, sodass die Detrusormuskulatur erfasst ist. Postoperativ kann zur Rezidivprophylaxe eine intravesikale Single-shot-Chemotherapie verabreicht werden. Methoden zur verbesserten Tumorvisualisation (insbesondere photodynamische Diagnostik) helfen, besonders bei multilokulärem Befund oder Carcinoma in situ (CIS) bessere Detektionsraten zu erreichen sowie das Rezidiv- und Progressionsrisiko zu senken. In Abhängigkeit von der Histologie ergibt sich das weitere Vorgehen: bei nicht muskelinvasivem Blasenkarzinom Nachsorge, adjuvante Instillationstherapie mittels Chemotherapie oder Bacillus Calmette-Guérin (BCG), die Nachresektion („second look TUR-B“), die Frühzystektomie oder bei muskelinvasivem Blasenkarzinom die Zystektomie oder (onkologisch nachrangig) die trimodale Therapie mit erneuter TUR‑B, Radiotherapie und Chemotherapie. Mögliche Komplikationen im Rahmen der TUR‑B sind v. a. Nachblutung mit Blasentamponade, extra- oder intraperitoneale Blasenperforation oder Infektionen des Urogenitaltrakts.

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“…NBI enhance the contrast between the superficial mucosa and microvascular structures via only emitting two bandwidths of illumination, 415 nm (blue) and 540 nm (green) ( 18 , 19 ). Assisted by specialized cystoscopes, surgeons could notice abnormal microvasculature and perform NBI-guided TURBT without prior instillation of dyes ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

“…A previous systematic review and meta-analysis suggested that novel visualization methods assisted TUR (VA-TUR) by PDD or NBI can improve cancer detection and decrease the risk of BC recurrence in the short and long term, compared with white light ( 20 , 21 ). VA-TUR have been recommended as weak evidence in the latest European Association of Urology Guidelines on NMIBC ( 22 ).…”

Section: Introductionmentioning

confidence: 99%

Novel Visualization Methods Assisted Transurethral Resection for Bladder Cancer: An Updated Survival-Based Systematic Review and Meta-Analysis

Li¹,

Cao²,

Ma³

et al. 2021

Front. Oncol.

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BackgroundPhotodynamic diagnosis and narrow-band imaging could help improve the detection rate in transurethral resection (TUR) of bladder cancer. It remained controversial that the novel visualization method assisted transurethral resection (VA-TUR) could elongate patients’ survival compared to traditional TUR.MethodsWe performed electronic and manual searching until December 2020 to identify randomized controlled trials comparing VA-TUR with traditional TUR, which reported patients’ survival data. Two reviewers independently selected eligible studies, extracted data, assessed the risk of bias. Meta-analysis was conducted according to subgroups of types of visualization methods (A) and clinical stage of participants. Publication bias was detected.ResultsWe included 20 studies (reported in 28 articles) in this review. A total of 6,062 participants were randomized, and 5,217 participants were included in the analysis. Only two studies were assessed at low risk of bias. VA-TURB could significantly improve the recurrence-free survival (RFS) (HR = 0.72, 95% CI: 0.66 to 0.79, P <0.00001, I2 = 42%) and progression-free survival (PFS) (HR = 0.62, 95% CI: 0.46 to 0.82, P <0.0008, I2 = 0%) compared with TUR under white light. The results remain stable whatever the type of visualization method. The difference could be observed in the non-muscle-invasive bladder cancer (NMIBC) population (P <0.05) but not in the mixed population with muscle-invasive bladder cancer (MIBC) participants (P >0.05).ConclusionVA-TUR could improve RFS and PFS in NMIBC patients. No significant difference is found among different types of VA-TUR. VA-TUR may be not indicated to MIBC patients.

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Clinical relevance of narrow-band imaging in flexible cystoscopy: the DaBlaCa-7 study

Abstract: NBI can be a useful tool in clinical decision making as a supplement to WL because it yields a significantly higher detection rate than WL cystoscopy alone. This is particularly relevant in patients with known recurrent NMIBC.

Cited by 17 publications

References 17 publications

Detection and recurrence rate of transurethral resection of bladder tumors by narrow-band imaging: Prospective, randomized comparison with white light cystoscopy

Detection and recurrence rate of transurethral resection of bladder tumors by narrow-band imaging: Prospective, randomized comparison with white light cystoscopy

Transurethrale Resektion von Blasentumoren (TUR-B)

Novel Visualization Methods Assisted Transurethral Resection for Bladder Cancer: An Updated Survival-Based Systematic Review and Meta-Analysis

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