Clinical relevance of intestinal peptide uptake

Freeman, Hugh James

doi:10.4292/wjgpt.v6.i2.22

Cited by 24 publications

(17 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PepT1 polymorphisms in the SLC15A1 gene have been associated with IBD ( 191 ) and NOD2 polymorphisms with CD ( 190 ) . The clinical relevance of intestinal uptake in disease has recently been reviewed by Freeman ( 192 ) .…”

Section: Peptide Permeabilitymentioning

confidence: 99%

Intestinal barrier dysfunction: implications for chronic inflammatory conditions of the bowel

Miner-Williams

Moughan

2016

Nutr. Res. Rev.

View full text Add to dashboard Cite

The intestinal epithelium of adult humans acts as a differentially permeable barrier that separates the potentially harmful contents of the lumen from the underlying tissues. Any dysfunction of this boundary layer that disturbs the homeostatic equilibrium between the internal and external environments may initiate and sustain a biochemical cascade that results in inflammation of the intestine. Key to such dysfunction are genetic, microbial and other environmental factors that, singularly or in combination, result in chronic inflammation that is symptomatic of inflammatory bowel disease (IBD). The aim of the present review is to assess the scientific evidence to support the hypothesis that defective transepithelial transport mechanisms and the heightened absorption of intact antigenic proinflammatory oligopeptides are important contributing factors in the pathogenesis of IBD.

show abstract

Section: Peptide Permeabilitymentioning

confidence: 99%

Intestinal barrier dysfunction: implications for chronic inflammatory conditions of the bowel

Miner-Williams

Moughan

2016

Nutr. Res. Rev.

View full text Add to dashboard Cite

show abstract

“…A standard deviation of ±10% was entered for the values of heights. Expression level of transporter: Lisinopril is a substrate for the efflux peptide transporter-1, which is maximally expressed in duodenum and jejunum and less in ileum and colon present at the brush border of the small intestine [ 43 ]. Taking the above into account, for the creation of population, the expressed level of the transporter was taken as 100% in the PK-Sim data base.…”

Section: Methodsmentioning

confidence: 99%

Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model

Rashid

Sarfraz

Arafat

et al. 2020

BMC Pharmacol Toxicol

View full text Add to dashboard Cite

Background: This study aimed to assess the pediatric lisinopril doses using an adult physiological based pharmacokinetic (PBPK) model. As the empirical rules of dose calculation cannot calculate gender-specific pediatric doses and ignores the age-related physiological differences. Methods: A PBPK model of lisinopril for the healthy adult population was developed for oral (fed and fasting) and IV administration using PK-Sim MoBI® and was scaled down to a virtual pediatric population for prediction of lisinopril doses in neonates to infants, infants to toddler, children at preschool age, children at school age and the adolescents. The pharmacokinetic parameters were predicted for the above groups at decremental doses of 20 mg, 10 mg, 5 mg, 2.5 mg, and 1.5 mg in order to accomplish doses producing the pharmacokinetic parameters, similar (or comparable) to that of the adult population. The above simulated pediatric doses were compared to the doses computed using the conventional four methods, such as Young's rule, Clark's rule, and weight-based and body surface area-based equations and the dose reported in different studies. Results: Though the doses predicted for all subpopulations of children were comparable to those calculated by Young's rule, yet the conventional methods overestimated the pediatric doses when compared to the respective PBPK-predicted doses. The findings of previous real time pharmacokinetic studies in pediatric patients supported the present simulated dose. Conclusion: Thus, PBPK seems to have predictability potential for pediatric dose since it takes into consideration the physiological changes related to age and gender.

show abstract

“…The PepT1 transporter is located in the microvillus membrane and has a wellestablished role as a transporter for di-and tri-peptides. Dietary intake and amino acid composition of the dietary protein increases the expression of PepT1 [52] . Primarily, expression of PepT1 is prevalent in the small intestine, but limited in the colon.…”

Section: Discussionmentioning

confidence: 99%

Nutritional and health benefits of semi-elemental diets: A comprehensive summary of the literature

Alexander¹,

Bylsma²,

Elkayam³

et al. 2016

WJGPT

View full text Add to dashboard Cite

AIM:To critically review and summarize the literature on nutritional and health outcomes of semi-elemental formulations on various nutritionally vulnerable patient populations who are unable to achieve adequate nutrition from standard oral diets. METHODS:We conducted a comprehensive literature search of Pubmed and Embase databases. We manually screened articles that examined nutritional and health outcomes (e.g. , growth, disease activity, gastrointestinal impairment, mortality, and economic impact) among various patient groups receiving semi-elemental diets. This review focused on full-text articles of randomized controlled clinical trials and other intervention studies, but pertinent abstracts and case studies were also included. Results pertaining primarily to tolerance, digestion, and absorption were summarized for each patient population in this systematic review.

show abstract

Clinical relevance of intestinal peptide uptake

Cited by 24 publications

References 42 publications

Intestinal barrier dysfunction: implications for chronic inflammatory conditions of the bowel

Intestinal barrier dysfunction: implications for chronic inflammatory conditions of the bowel

Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model

Nutritional and health benefits of semi-elemental diets: A comprehensive summary of the literature

Contact Info

Product

Resources

About