Clinical relevance of <i>p</i>‐<i>tert</i>‐butylphenol‐formaldehyde resin (<scp>PTBP‐FR</scp>) contact allergy among general dermatology patients

Lintu, P.; Soramäki, Iina; Liippo, Jussi

doi:10.1111/cod.13602

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…Mainly domestic glues, amputation prostheses, leather watch straps and neoprene orthopaedic knee braces belong to this group. However, PTBP-formaldehyde resin as a preservative can also be found in nail cosmetics and deodorants [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Preservative Contact Hypersensitivity among Adult Atopic Dermatitis Patients

Németh

Temesvári

Holló

et al. 2022

Life

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Atopic dermatitis (AD) is a chronic inflammatory disease characterised by an impaired skin barrier. The prolonged use of topical preparations containing medications, emollients, fragrances and preservatives may increase the risk of contact hypersensitivity (CHS). In the Allergy Outpatient Unit of the Department of Dermatology, Venereology and Dermatooncology of Semmelweis University, 5790 adult patients were patch tested between 2007–2021 with the European Environmental Baseline Series according to international standards. Among all the tested adult patients, 723 had preservative CHS (PCHS) and 639 had AD. Among the 723 PCHS patients, 68 (9.4%) had AD; the female to male ratio was 3:1 in this group. Out of 639 AD patients, 68 had PCHS (10.6%). In the AD-PCHS group, 83.8% had CHS to methylisothiazolinone (MI) (tested from 2014), 36.8% to Kathon CG®, 16.2% to methyldibromo-glutaronitrile, 11.8% to paraben, 7.4% to formaldehyde, 4.4% to para-tert-butylphenol-formaldehyde resin and 1.5% to Quaternium-15. The most common concomitant PCHS combination was Kathon CG® + MI. Most patients (32.4%) belonged to the age group of 21–30, and skin symptoms affected mostly the limbs and face. The most common other concomitant allergens were nickel, lanolin alcohol and balsam of Peru. Preservatives (especially MI and Kathon CG®) are important contact allergens in adult AD, mostly among young women. The rate of AD in the PCHS group and the rate of PCHS in the AD group is remarkable; thus, the role of PCHS should be highlighted in the topical therapy and in the prevention of possible AD exacerbations.

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Section: Discussionmentioning

confidence: 99%

Preservative Contact Hypersensitivity among Adult Atopic Dermatitis Patients

Németh

Temesvári

Holló

et al. 2022

Life

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“…patch test reactions in Finnish dermatology patients. 1 As the authors mention, PTBP-FR allergic contact dermatitis was indeed identified in shoe glue in the 1950s, but this complex resin is not uniformly allergenic.…”

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confidence: 99%

Response to: Clinical relevance of p‐tert‐butylphenol‐formaldehyde resin (PTBP‐FR) contact allergy among general dermatology patients

Hamann

2020

Contact Dermatitis

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Miscellaneous Organic Polymers

Skoglund,

Roy

2023

Patty's Toxicology

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Polymers are advanced materials composed of many repeating monomer units; organic polymers are polymers that essentially contain carbon atoms in the backbone. Significant volumes of organic polymers are manufactured each year. Plastic products manufactured from these polymers can be as simple as toilet seats and single‐use grocery bags, or as tough as bulletproof materials, space suits, chemical resistant gaskets, or as sophisticated as implantable medical devices. Key features of plastics are modified by the selection of the resins, the manufacturing processes, and the additives used. Plastics are divided up into three main groups: thermoplastics, thermosetting plastics, and elastomers. Exposure to monomers, polymers, resins, and plastics can occur during the initial polymerization and manufacturing of the resins, the subsequent polymerization and manufacturing of the plastics and finished products, during use of the finished product, and during the product's end‐of‐life stage. This chapter focuses on the human health hazard profile of several miscellaneous organic polymer resins used to form thermoplastics and thermosetting plastics. These polymers include phenolic resins, aminoplastic resins, furfuryl alcohol resins, polyvinylpyrrolidone resins, polybenzimidazole resins, and polylactic acid resins. Most of the plastics manufactured from these resins are resistant to biodegradation; however, a few can be biodegraded. In addition to the toxicology profiles, this chapter discusses production and use, potential exposures, hazard classification, sensitive applications such as food‐contact and medical applications, and exposure guidelines.

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Clinical relevance of p‐tert‐butylphenol‐formaldehyde resin (PTBP‐FR) contact allergy among general dermatology patients

Cited by 6 publications

References 11 publications

Preservative Contact Hypersensitivity among Adult Atopic Dermatitis Patients

Preservative Contact Hypersensitivity among Adult Atopic Dermatitis Patients

Response to: Clinical relevance of p‐tert‐butylphenol‐formaldehyde resin (PTBP‐FR) contact allergy among general dermatology patients

Miscellaneous Organic Polymers

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