Clinical Relevance of Hla Antibody (Specificity and Titer) and Donor Specific Flow Cytometry Crossmatches in Sirolimus Treated Renal Allograft Recipients

Kerman, Ronald H.; Fernandez, I; Podder, Hemangshu; Knight, Richard J.; Katz, Sanford; Buren, C. Van; Kahan, Barry D.

doi:10.1097/00007890-200407271-00438

Cited by 2 publications

(2 citation statements)

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“…Our study of HLA antibody titers suggests that patients with higher titers experience severe acute rejections and even early graft loss, compared with patients with lower titers, for whom chronic rejections are more common. Similar associations have been noted for kidney recipients with alloantibodies detected before transplantation [33] and after allograft loss [34]. We speculate that low levels of anti-HLA antibodies probably do not lead to immediate and severe effects compared with high-titer antibodies.…”

Section: Discussionsupporting

confidence: 86%

Clinical Relevance of Anti-HLA Antibodies Detected by Flow-Cytometry Bead-Based Assays—Single-Center Experience

et al. 2006

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Section: Discussionsupporting

confidence: 86%

Clinical Relevance of Anti-HLA Antibodies Detected by Flow-Cytometry Bead-Based Assays—Single-Center Experience

et al. 2006

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“…Antigen density of single-antigen beads is also not sufficiently consistent to permit reproducible quantification, thereby precluding a consensus threshold. There are data in the renal transplant population to suggest that titers of >1:32 predict graft loss (10), but published data to guide heart transplant candidates are scarce.…”

Section: Quantification Of Circulating Antibodiesmentioning

confidence: 99%

Management of the sensitized adult heart transplant candidate

Eckman

Hanna

Taylor

et al. 2010

Clinical Transplantation

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Heart transplant recipients sensitized to human leukocyte antigens comprise a challenging subgroup of patients. Sensitization has been associated with a variety of effects that determine short-term and long-term outcomes. These include a higher rate of acute rejection and graft loss, and a heightened risk for developing cardiac allograft vasculopathy. Because of improvements in both tissue typing and immunomodulatory therapies coupled with the growing population receiving mechanical circulatory support/LVAD, the percent of sensitized patients listed for heart transplantation has increased, inflicting a greater burden to the already scarce donor pool. Despite these potentially adverse developments, pre-transplant immunologic management has resulted in decreased waiting times and outcomes that were not possible over 10 yr ago. The following review will focus on the contemporary management of the sensitized heart transplant candidate and highlight therapies that have allowed the successful transplantation of this growing and challenging patient population, including several approaches in development.

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Clinical Relevance of Hla Antibody (Specificity and Titer) and Donor Specific Flow Cytometry Crossmatches in Sirolimus Treated Renal Allograft Recipients

Cited by 2 publications

References 0 publications

Clinical Relevance of Anti-HLA Antibodies Detected by Flow-Cytometry Bead-Based Assays—Single-Center Experience

Clinical Relevance of Anti-HLA Antibodies Detected by Flow-Cytometry Bead-Based Assays—Single-Center Experience

Management of the sensitized adult heart transplant candidate

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