Clinical Relevance of Changes in Peripheral Blood Cells After Intracranial Aneurysm Rupture

Morga, Rafał; Dziedzic, Tomasz; Moskała, Marek; Słowik, Agnieszka; Pera, Joanna

doi:10.1016/j.jstrokecerebrovasdis.2020.105293

Cited by 13 publications

(8 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Except for cerebral small vessel disease (HR = 1.09, 95%CI: 0.95–1.25, P = 0.233), coronary heart disease (HR = 1.13, 95%CI: 0.94–1.36, P = 0.188), and venous thrombosis (HR = 4.65, 95%CI: 0.66–32.71, P = 0.122), there was a consistent statistical significance for the risk of ischemic stroke (HR = 1.31, 95%CI: 1.06–1.63, P = 0.013), hemorrhagic stroke (HR = 1.22, 95%CI: 1.10–1.37, P < 0.001), myocardial infarction (HR = 1.11, 95%CI: 1.01–1.23, P = 0.027), and peripheral arterial disease (HR = 1.51, 95%CI: 1.18–1.93, P = 0.001) ( Table 2 ). Furthermore, nine studies reported differences in SII levels at the onset of CVD compared with the general population ( 28 , 30 , 32 – 34 , 36 – 39 ), and all studies consistently suggested that SII levels at the onset of CVD were significantly higher than that in controls, with a median elevation range of 12–1,340. The random-effects model was used due to substantial heterogeneity ( I 2 = 99.7%, P < 0.001), and the pooled WMD was 355.2 (95% CI: 234.8–475.6, P < 0.001) ( Figure 2B ), further confirming the correlation between SII and CVD development.…”

Section: Resultsmentioning

confidence: 96%

“…Of the 152,996 participants, 102,822 were male and the mean/median age ranged from 33 to 70 years. The published studies were conducted in four regions: China ( 28 , 29 , 31 , 32 , 34 , 35 , 39 , 40 ), Turkey ( 30 , 33 , 38 ), Poland ( 36 ), and United States ( 37 ). The determination of SII cutoff values was based on ROC analysis, Youden index, and quartiles.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Systemic immune-inflammation index as a potential biomarker of cardiovascular diseases: A systematic review and meta-analysis

Wang

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

BackgroundSeveral studies have investigated the value of the systemic immune-inflammation index (SII) for predicting cardiovascular disease (CVD), but the results were inconsistent. Therefore, a meta-analysis and systematic review were conducted to assess the correlation between SII and risk of CVD.Materials and methodsTwo investigators systematically searched PubMed, Embase, Web of Science, Cochrane library, and CINAHL databases to identify all studies that examined the association between SII levels and CVD. The risk estimates of CVD for people with high SII compared to those with low SII levels and the weighted mean difference (WMD) between the CVD and control groups were pooled using fixed- or random-effects models based on the heterogeneity test. We used the Newcastle-Ottawa Scale to assess the risk of bias in eligible studies, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was applied to rate the certainty of evidence.ResultsA total of 13 studies with 152,996 participants were included for analysis. The overall pooled results showed that higher SII was significantly associated with an increased risk of CVD (HR = 1.39, 95%CI: 1.20–1.61, P < 0.001). This increased risk could be observed in almost all CVD subtypes, including ischemic stroke (HR = 1.31, 95%CI: 1.06–1.63, P = 0.013), hemorrhagic stroke (HR = 1.22, 95%CI: 1.10–1.37, P < 0.001), myocardial infarction (HR = 1.11, 95%CI: 1.01–1.23, P = 0.027), and peripheral arterial disease (HR = 1.51, 95%CI: 1.18–1.93, P = 0.001). There were no significant but still similar trends in venous thrombosis (HR = 4.65, 95%CI: 0.66–32.71, P = 0.122), cerebral small vessel disease (HR = 1.09, 95%CI: 0.95–1.25, P = 0.233), and acute coronary syndrome (HR = 1.08, 95%CI: 0.96–1.22, P = 0.200). Furthermore, the pooled results showed that SII levels at the onset of CVD were significantly higher than that in the general population (WMD = 355.2, 95%CI: 234.8–475.6, P < 0.001), which was consistent across different CVD subtypes. The GRADE assessment suggested that the quality of current evidence from observational studies was low or very low.ConclusionThis study indicated that SII may be a potential biomarker for CVD development and elevated SII is associated with an increased risk of CVD. However, the quality of evidence is generally low. Additional well-designed studies are necessary to determine the optimal cutoff value and to characterize the benefited population.

show abstract

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Systemic immune-inflammation index as a potential biomarker of cardiovascular diseases: A systematic review and meta-analysis

Wang

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…For example, the spleen contracts following ischemic stroke, activating a peripheral immune response that may exacerbate ongoing brain injury [ 96 ]. Analyses of the neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios reveal an early state following aSAH [ 94 , 97 ]. While there is growing data suggesting that peripheral immune dysregulation following hemorrhagic strokes may be important in brain injury pathogenesis and outcomes, details of the crosstalk between the brain and the immune system remain unclear [ 98 ].…”

Section: Immune Dysregulation Following Asahmentioning

confidence: 99%

The Pathogenesis of Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage

Kuo

Huang

2021

IJMS

View full text Add to dashboard Cite

Hydrocephalus is a common complication of aneurysmal subarachnoid hemorrhage (aSAH) and reportedly contributes to poor neurological outcomes. In this review, we summarize the molecular and cellular mechanisms involved in the pathogenesis of hydrocephalus following aSAH and summarize its treatment strategies. Various mechanisms have been implicated for the development of chronic hydrocephalus following aSAH, including alterations in cerebral spinal fluid (CSF) dynamics, obstruction of the arachnoid granulations by blood products, and adhesions within the ventricular system. Regarding molecular mechanisms that cause chronic hydrocephalus following aSAH, we carried out an extensive review of animal studies and clinical trials about the transforming growth factor-β/SMAD signaling pathway, upregulation of tenascin-C, inflammation-dependent hypersecretion of CSF, systemic inflammatory response syndrome, and immune dysregulation. To identify the ideal treatment strategy, we discuss the predictive factors of shunt-dependent hydrocephalus between surgical clipping and endovascular coiling groups. The efficacy and safety of other surgical interventions including the endoscopic removal of an intraventricular hemorrhage, placement of an external ventricular drain, the use of intraventricular or cisternal fibrinolysis, and an endoscopic third ventriculostomy on shunt dependency following aSAH were also assessed. However, the optimal treatment is still controversial, and it necessitates further investigations. A better understanding of the pathogenesis of acute and chronic hydrocephalus following aSAH would facilitate the development of treatments and improve the outcome.

show abstract

“…This process is promoted by inflammatory processes ( 8 ). Previous studies have analyzed the associations of various inflammatory markers with the occurrence of CV or DCI, and prognosis of patients with aSAH ( 9 , 12 , 27 ). Blood parameters, such as inflammation-based scores, WBC derives, and hsCRP have been investigated as inflammatory markers in aSAH ( 8 , 27 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical relevance of serum procalcitonin in patients with aneurysmal subarachnoid hemorrhage

Kim

et al. 2022

Exp Ther Med

View full text Add to dashboard Cite

Cerebral vasospasm (CV), which is closely related to the prognosis of aneurysmal subarachnoid hemorrhage (aSAH), is known to be related to an inflammatory reaction. The aim of the present study was to investigate predictable values of procalcitonin (PCT) for systemic infection and the development of CV in patients with aSAH. Patients who underwent endovascular treatment for aSAH were retrospectively enrolled. Receiver operating characteristic curve analysis was performed to evaluate the predicable value of PCT for systemic infection and CV in patients with aSAH. To clarify the association of PCT and CV, additional subgroup analysis was performed for patients without systemic infection. Multivariate logistic regression was used to explore the associations of PCT and the development of CV. A total of 374 patients with aSAH were enrolled. Of them, 164 (43.9%) had systemic infection. Optimal cutoff value of PCT for systemic infection was 0.21 ng/ml (P<0.001). In subgroup analysis of 210 patients without infection, 0.09 ng/ml of PCT level was defined as the optimal cutoff value for predicting CV after aSAH (P<0.001). In multivariate logistic regression analysis, PCT was a significant predicting factor for CV (odds ratio, 1.82; 95% confidence interval, 1.42-2.96; P=0.015). Overall, PCT had predictable value for systemic infection and the development of CV in patients who underwent endovascular treatment for aSAH. Further studies are needed to validate our results and establish its clinical applicability.

show abstract

Clinical Relevance of Changes in Peripheral Blood Cells After Intracranial Aneurysm Rupture

Cited by 13 publications

References 36 publications

Systemic immune-inflammation index as a potential biomarker of cardiovascular diseases: A systematic review and meta-analysis

Systemic immune-inflammation index as a potential biomarker of cardiovascular diseases: A systematic review and meta-analysis

The Pathogenesis of Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage

Clinical relevance of serum procalcitonin in patients with aneurysmal subarachnoid hemorrhage

Contact Info

Product

Resources

About