2020
DOI: 10.1016/s2666-5247(20)30001-x
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Clinical relevance and plasmid dynamics of mcr-1-positive Escherichia coli in China: a multicentre case-control and molecular epidemiological study

Abstract: Background Although the emergence of the plasmid-mediated colistin resistance gene, mcr-1, caused global concern, little is known about its clinical implications and transmission characteristics over time. We aimed to investigate the clinical relevance of infection with mcr-1-positive Escherichia coli isolates and to investigate long-term plasmid dynamics. MethodsWe did a multicentre case-control study and molecular epidemiological survey of mcr-1-positive E coli infections. E coli isolates from four hospitals… Show more

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Cited by 32 publications
(26 citation statements)
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“…1 ). The most common ST among chromosomally-encoded mcr - 1 -positive E. coli isolates was ST10 (n = 10, 18.5%), which is consistent with the main host for plasmid-mediated mcr - 1 on E. coli species [ 3 , 4 , 12 ]. The phylogeny demonstrated two sequence clusters (SCs), except for two isolates which were distinct from two SCs as the outgroup (Fig.…”
Section: Short Reportsupporting
confidence: 58%
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“…1 ). The most common ST among chromosomally-encoded mcr - 1 -positive E. coli isolates was ST10 (n = 10, 18.5%), which is consistent with the main host for plasmid-mediated mcr - 1 on E. coli species [ 3 , 4 , 12 ]. The phylogeny demonstrated two sequence clusters (SCs), except for two isolates which were distinct from two SCs as the outgroup (Fig.…”
Section: Short Reportsupporting
confidence: 58%
“…Accumulated evidence showed that banning of colistin in animal feed efficiently restricted mcr-1 prevalence, not only in animals but also in humans and the whole ecosystem in China [2][3][4]. However, our previous study showed that a low proportion of Escherichia coli carrying chromosomally-encoded mcr-1 continually existed in the ecosystem [4], which was sporadically reported by other studies as well [9][10][11].…”
Section: Short Reportmentioning
confidence: 62%
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“…To date, mcr-1 is the most studied mcr gene variant, and the dissemination has been described in detail. Multiple studies agree that even though mcr-1 has been detected in a few isolates from the 1980s 18 , it has been appearing with increasing frequencies in samples between 2011 and 2017 and decreasing in later years 8,18,19,47 . We see a similar trend in the mcr-1 positive frequencies, but the levels seem to increase from 2008 with the highest levels in 2015; the year of mcr-1 being reported 4 (Figure 1).…”
Section: Discussionmentioning
confidence: 97%