Clinical Reduction of Gingivitis through the Use of a Mouthwash Containing Two Quaternary Ammonium Compounds

Abstract

A commercially available antimicrobial mouthrinse was evaluated among students in Mexican boarding schools. The application was made daily for 3 months under the direct supervision of the project personnel. The observations indicated that the use of this mouthrinse decreased gingivitis substantially in comparison to the use of a control rinse which consisted of flavored water. It is concluded that this mouthwash, containing the known antimicrobial agents cetylpyridinium chloride and domiphen bromide, can be of clinical benefit if conscientiously applied as an adjunct in an oral hygiene regimen of regular toothbrushing with a dentifrice.

The efficacy of 0.12% chlorhexidine mouthrinse compared with 0.2% on plaque accumulation and periodontal parameters: a systematic review

“…Segreto et al (1986) (VI) assessed gingivitis with the Papillary‐Marginal‐Gingivitis Index (de la Rosa & Sturzenberger 1976).…”

In vitro activity of A-16686, a potential antiplaque agent

“…However, there are few studies on the use of antibiotics for caries control in man (7,13,18). Other agents, such as CHX and other cationic compounds, are more extensively employed in various formulations (2,3,5,6,17). These compounds showed good bactericidal activity by reducing cariogenic bacteria and good antiplaque activity (2,15,24,25).…”

In Vitro Evaluation of Seven Cationic Detergents as Antiplaque Agents

“…Cationic agents are also of interest because of potential reversible binding (substantivity) to anionic groups on oral mucous membranes (2,21,22,25,26), which could permit possible prolonged intraoral retention and sustained release of such cationic antiseptics. Recent studies have demonstrated modest in vivo and in vitro antiplaque activities of three quaternary ammonium detergents, namely, cetylpyridinium chloride, domiphen bromide, and benzylalkonium chloride (1,6,12,27,35). In those studies, however, the optimal conditions required for in vivo efficacy were not evaluated.…”

“…PBI and CC. To employ a potential thera-X peutic utility index that could reflect the inteo gration of the effects of concentration, duration, and frequency of treatment required to achieve a bactericidal effect, the product of these parameters was computed for each of the five most t potent agents and for each of the test microorganisms and was expressed as a plaque bacteri-' cidal index (PBI) (32 Studies on the antiplaque activities of cationic detergents have been inconclusive with respect to their effectiveness against in vivo dental plaques (1,6,12,27,35). The studies of Sturzenberger and associates indicated that CPC (1.23 mM) or domiphen bromide (0.6 mM) used as adjuncts to tooth brushing effectively reduced amounts of bacterially undefined in vivo dental plaques as compared to a placebo tooth-brushing control (27).…”