Clinical Records: A Case Report of Wegener's Granulomatosis Limited to the Ear

Ito, Yukiko; Shinogi, Jun; Yuta, Atsushi; Okada, Emiko; Taki, Michio; Matsukage, Hiroshi

doi:10.1016/s0385-8146(12)80264-1

Cited by 9 publications

(5 citation statements)

References 19 publications

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“…Fauci et al (1983) found only five patients out of 85 in their series complaining of aural symptoms. A case of Wegener's granulomatosis limited to the ear without involvement of the other systems was reported (Ito et al, 1991). In this case, clinical and laboratory and pathological investigations were consistent with Wegener's granulomatosis from the initial presentation.…”

Section: Discussionsupporting

confidence: 53%

Cochlear implantation in a case of Wegener's granulomatosis

1996

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Cochlear implantation is now a routine clinical procedure for deaf patients in many countries (Gibson, 1987). It replaces the function of damaged cochlear hair cells and, therefore, detects sound and by electrical stimulation produces an appropriate signal in the remaining cochlear nerve fibres (House and Berliner, 1991). Wegener's granulomatosis is an uncommon auto-immune disease. It has a peak incidence at the fifth decade with slight male predominance. Nasal problems are the predominant presentation with otological manifestations presenting rarely. We report a case of Wegener's granulomatosis presenting with total hearing loss and after right cochlear implantation a free field threshold of 40 dB and 20 per cent Bamford-Kowal-Bench (BKB) speech test.We conclude that Wegener's granulomatosis is not an absolute contraindication for cochlear implantation.

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Section: Discussionsupporting

confidence: 53%

Cochlear implantation in a case of Wegener's granulomatosis

1996

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“… 3 Occasionally the otologic manifestation may be the first and only sign of the disease. 4,5 In these localized cases, biopsy specimens are often small, and it is frequently difficult to make a definite histologic diagnosis on this alone. 6 Cytoplasmic pattern antineutrophil cytoplasmic antibodies (c‐ANCA), first reported in 1985 by Van der Woude et al, 7 are highly specific for WG, especially in the active phase.…”

Section: Introductionmentioning

confidence: 99%

Otologic Manifestations of Wegener's Granulomatosis

et al. 2002

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In localized cases, biopsy specimens are often small, and it is frequently difficult to make a histologic diagnosis. The prognosis for hearing was poor when appropriate treatment was not given in the early stages of the disease. Therefore, WG should be included in the differential diagnosis in cases of atypical inflammatory states of the ear. Early diagnosis and appropriate treatment are important to prevent irreversible changes in the middle ear and inner ear.

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“…The commonest site had been the nose and paranasal sinuses [10]. The other sites are the orbit [11], larynx and trachea [12], ear [13], central nervous system [14] and oral cavity [15]. The absence of renal involvement, which has been the most important prognostic factor in this disease, reduces the morbidity significantly in these cases.…”

Section: Discussionmentioning

confidence: 99%

Localised Wegener’s Granulomatosis in Otolaryngology: A Review of Six Cases

Ahmad

Lee

Nagendran

et al. 2000

ORL

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Wegener’s granulomatosis (WG) is a necrotising granulomatous disease affecting the upper and/or lower respiratory tracts and is associated with focal glomerulonephritis. Formerly believed to be a multisystem disease, a localised form (LWG) is now recognised as a distinct subtype. We describe 6 cases of LWG with no renal or pulmonary involvement detected at the presentation or during follow-up. The total follow-up period ranged from 3 to 7 years in 5 cases. The diagnosis was based on clinical features, antineutrophil cytoplasmic antibody test and histological findings (necrotising granulomatous vasculitis, epithelioid granulomas with varying degrees of chronic inflammatory cells). All patients responded to standard immunosuppressive treatment. Our cases highlight the predilection of LWG for the head and neck region and hence these patients frequently present in the ENT departments. LWG has been discussed as a subtype of WG with a better prognosis and the previous literature has been reviewed on this subject. A high index of suspicion helped by serology and histology enables an early diagnosis, and commencement of proper treatment can prevent the irreversible destructive lesions.

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Clinical Records: A Case Report of Wegener's Granulomatosis Limited to the Ear

Cited by 9 publications

References 19 publications

Cochlear implantation in a case of Wegener's granulomatosis

Cochlear implantation in a case of Wegener's granulomatosis

Otologic Manifestations of Wegener's Granulomatosis

Localised Wegener’s Granulomatosis in Otolaryngology: A Review of Six Cases

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