Clinical recording of pressure on the spinal cord and cauda equina

Magnæs, B.

doi:10.3171/jns.1982.57.1.0048

Cited by 17 publications

(1 citation statement)

References 14 publications

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“…Forward bending may relieve claudication by increasing the spinal canal area, hence improving CSF circulation [ 1 , 11 , 13 , 16 ]. A few previous studies have investigated the hydrodynamic parameters of CSF in the spinal canal of patients with spinal stenosis [ 13 , 17 ]. In our pilot study, CSF flow was attenuated at the lumbosacral level in patients with LSS who experienced neurogenic claudication compared to normal healthy controls [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Cerebrospinal fluid dynamics correlate with neurogenic claudication in lumbar spinal stenosis

Kim

et al. 2021

PLoS ONE

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Neurogenic claudication is a typical manifestation of lumbar spinal stenosis (LSS). However, its pathophysiology is still unclear. The severity of clinical symptoms has been shown not to correlate with the degree of structural stenosis. Altered cerebrospinal fluid (CSF) flow has been suggested as one of the causative factors of LSS. The objectives of this study were to compare CSF dynamics at the lumbosacral level between patients with LSS and healthy controls and to investigate whether CSF dynamics parameters explain symptom severity in LSS. Phase-contrast magnetic resonance imaging (PC-MRI) was conducted to measure CSF dynamics in 18 healthy controls and 9 patients with LSS. Cephalic peak, caudal peak, and peak-to-peak CSF velocities were evaluated at the lumbosacral level in the patients and controls. The power of CSF dynamics parameters to predict symptom severity was determined using a linear regression analysis adjusted for demographic and structural variables. Significantly attenuated CSF flow velocity was observed in the patients compared with the controls. The cephalic peak, caudal peak, and peak-to-peak velocities at the lumbar level were greater in the controls than in the patients (p<0.001). The predictive power increased most when the peak-to-peak velocity was added (adjusted R2 = 0.410) to the model with age, body mass index, and the minimum anterior-posterior diameter (adjusted R2 = 0.306), and the peak-to-peak velocity was the only statistically significant variable. CSF dynamics variables showed an association with the severity of LSS symptoms, independent of structural stenosis. PC-MRI can help to further our understanding of the pathophysiology of neurogenic claudication and support the diagnosis of LSS.

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Section: Introductionmentioning

confidence: 99%

Cerebrospinal fluid dynamics correlate with neurogenic claudication in lumbar spinal stenosis

Kim

et al. 2021

PLoS ONE

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Cerebrospinal fluid dynamics at the lumbosacral level in patients with spinal stenosis: A pilot study

Chun

Lee

Nam

et al. 2016

Journal Orthopaedic Research

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Spinal stenosis is a common degenerative condition. However, how neurogenic claudication develops has not been clearly elucidated. Moreover, cerebrospinal fluid physiology at the lumbosacral level has not received adequate attention. This study was conducted to compare cerebrospinal fluid hydrodynamics at the lumbosacral spinal level between patients with spinal stenosis and healthy controls. Twelve subjects (four patients and eight healthy controls; 25-77 years old; seven males) underwent phase-contrast magnetic resonance imaging to quantify cerebrospinal fluid dynamics. The cerebrospinal fluid flow velocities were measured at the L2 and S1 levels. All subjects were evaluated at rest and after walking (to provoke neurogenic claudication in the patients). The caudal peak flow velocity in the sacral spine (À0.25 AE 0.28 cm/s) was attenuated compared to that in the lumbar spine (À0.93 AE 0.46 cm/s) in both patients and controls. The lumbar caudal peak flow velocity was slower in patients (À0.65 AE 0.22 cm/s) than controls (À1.07 AE 0.49 cm/s) and this difference became more pronounced after walking (À0.66 AE 0.37 cm/s in patients, À1.35 AE 0.52 cm/s in controls; p ¼ 0.028). The sacral cerebrospinal fluid flow after walking was barely detectable in patients (caudal peak flow velocity: À0.09 AE 0.03 cm/s). Cerebrospinal fluid dynamics in the lumbosacral spine were more attenuated in patients with spinal stenosis than healthy controls. After walking, the patients experiencing claudication did not exhibit an increase in the cerebrospinal fluid flow rate as the controls did. Altered cerebrospinal fluid dynamics may partially explain the pathophysiology of spinal stenosis. ß

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Dynamic F waves in neurogenic claudication

London

England

1991

Muscle and Nerve

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Serial F waves were elicited before and after ambulation in 2 patients with neurogenic claudication. In both patients dynamic changes in F wave parameters consisting of either unelicitability or increased latencies occurred postexercise. The time course of these changes and their subsequent rapid reversibility over 15 minutes suggest ischemic-induced conduction block and slowing in proximal motor axons. These physiological changes may account for some of the dynamic neurological symptoms of this disorder. Moreover, F wave exercise testing may provide corroborative information for the diagnosis of neurogenic claudication.

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Clinical recording of pressure on the spinal cord and cauda equina

Cited by 17 publications

References 14 publications

Cerebrospinal fluid dynamics correlate with neurogenic claudication in lumbar spinal stenosis

Cerebrospinal fluid dynamics correlate with neurogenic claudication in lumbar spinal stenosis

Cerebrospinal fluid dynamics at the lumbosacral level in patients with spinal stenosis: A pilot study

Dynamic F waves in neurogenic claudication

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