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An adult with classic Hemophilia A experienced a very severe reaction to transfusion with cryoprecipitate which was manifested as an adverse pulmonary reaction with marked hypoxemia in spite of oxygen therapy. The patient had neither leukoagglutinins nor lymphocytoxic, anti-platelet, or anti-Gm antibodies. His IgA level was normal. The possibility that debris in the cryoprecipitate from leukocytes and platelets contributed to the reaction is discussed. SEVERE REACTIONS to cryoprecipitate have been rare during the decade of its availability. Poolzo has recommended the use of cryoprecipitate because the nonspecific allergic reactions seen with whole plasma are almost entirely absent with cryoprecipitate. Ahrons, et aL,I Rizza and matt hew^,^^ and Burman, et al.e have reported a few severe reactions to cryoprecipitate. Maycock, et aI.l5 and Rizza and BiggsZ3 have noted severe reactions after infusions of A H G concentrate. Adverse pulmonary reactions, characterized primarily by pulmonary insufficiency with patchy infiltrates radiographically, have infrequently been cited as a complication to transfusion with whole blood, packed red blood cells, and fresh frozen 19.27*30*31 Similar reactions have been termed allergic pulmonary edema or pulmonary hypersensitivity reactions. This is a report of an adverse pulmonary reaction to cryoprecipitate.
An adult with classic Hemophilia A experienced a very severe reaction to transfusion with cryoprecipitate which was manifested as an adverse pulmonary reaction with marked hypoxemia in spite of oxygen therapy. The patient had neither leukoagglutinins nor lymphocytoxic, anti-platelet, or anti-Gm antibodies. His IgA level was normal. The possibility that debris in the cryoprecipitate from leukocytes and platelets contributed to the reaction is discussed. SEVERE REACTIONS to cryoprecipitate have been rare during the decade of its availability. Poolzo has recommended the use of cryoprecipitate because the nonspecific allergic reactions seen with whole plasma are almost entirely absent with cryoprecipitate. Ahrons, et aL,I Rizza and matt hew^,^^ and Burman, et al.e have reported a few severe reactions to cryoprecipitate. Maycock, et aI.l5 and Rizza and BiggsZ3 have noted severe reactions after infusions of A H G concentrate. Adverse pulmonary reactions, characterized primarily by pulmonary insufficiency with patchy infiltrates radiographically, have infrequently been cited as a complication to transfusion with whole blood, packed red blood cells, and fresh frozen 19.27*30*31 Similar reactions have been termed allergic pulmonary edema or pulmonary hypersensitivity reactions. This is a report of an adverse pulmonary reaction to cryoprecipitate.
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