“Clinical, Radiological and Therapeutic Characteristics of Patients with COVID-19 in Saudi Arabia”

Shabrawishi, Mohammed; Algethamy, Manal; Naser, Abdallah Y; Ghazawi, Maher A; Alsharif, Ghaidaa F; Obaid, Elaf F; Melebari, Haitham A; Alamri, Dhaffer M; Brinji, Ahmad S; Jehani, Fawaz H Al; Almaimani, Wail; Ekram, Rakan; Alkhatib, K; Alwafi, Hassan

doi:10.1101/2020.05.07.20094169

Cited by 22 publications

(28 citation statements)

References 28 publications

(29 reference statements)

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“…Additionally, there were 20.9% of patients without viral pneumonia symptoms [16], which was opposite to previous studies [69,70]. The asymptomatic cases varied from 21.9%-49.5% [66,68,93,94].…”

Section: Mortality and Fatalitycontrasting

confidence: 62%

Epidemiologic, Clinical, and Laboratory Findings of the COVID-19 in the current pandemic: Systematic Review and Meta-analysis

Xie

Wang

Liao

et al. 2020

Preprint

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Background: The COVID-19 pandemic has affected the world deeply, with more than 3,000,000 people infected and nearly 200,000 deaths. This review aimed to summarize the epidemiologic traits, clinical spectrum, CT results and laboratory findings of the COVID-19 pandemic.Methods: We scoped for relevant literatures published during 1st Dec 2019 to 23rd Apr 2020 based on four databases using English and Chinese languages. We reviewed and analyzed the relevant clinic outcomes of COVID-19.Results: The COVID-19 pandemic was found to have a higher transmission rate compared to SARS and MERS and involved 4 stages of evolution. The basic reproduction number (R0) is 3.32 (95% CI:3.24-3.39), the incubation period was 5.24 days (95% CI:3.97-6.50, 5 studies) on average, and the average time for symptoms onset varied by countries. Common clinical spectrums identified included fever (38.1-39.0℃), cough and fatigue, with Acute Respiratory Distress Syndrome (ARDS) being the most common complication reported. Body temperatures above 39.0 ℃, dyspnea, and anorexia were more common symptoms in severe patients. Aged over 60 years old, having co-morbidities, and developing complications were the commonest high-risk factors associated with severe conditions. Leucopenia and lymphopenia were the most common signs of infection while liver and kidney damage were rare but may cause bad outcomes for patients. The bilateral, multifocal Ground-Glass Opacification (GGO) on peripheral, and the consolidative pulmonary opacity were the most frequent CT results and the tendency of mortality rates differed by region.Conclusions: We provided a bird’s-eye view of the COVID-19 during the current pandemic, which will help better understanding the key traits of the disease. The findings could be used for disease’s future research, control and prevention.

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Section: Mortality and Fatalitycontrasting

confidence: 62%

Epidemiologic, Clinical, and Laboratory Findings of the COVID-19 in the current pandemic: Systematic Review and Meta-analysis

Xie

Wang

Liao

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Additionally, there were 20.9% of patients without viral pneumonia symptoms [16], which was opposite to previous studies [69,70]. The asymptomatic cases varied from 21.9-49.5% [66,68,93,94].…”

Section: Clinical Spectrum Common Symptomsmentioning

confidence: 65%

Epidemiologic, clinical, and laboratory findings of the COVID-19 in the current pandemic: systematic review and meta-analysis

et al. 2020

View full text Add to dashboard Cite

Background: The COVID-19 pandemic has affected the world deeply, with more than 14,000,000 people infected and nearly 600,000 deaths. This review aimed to summarize the epidemiologic traits, clinical spectrum, CT results and laboratory findings of the COVID-19 pandemic. Methods: We scoped for relevant literatures published during 1st December 2019 to 16th July 2020 based on three databases using English and Chinese languages. We reviewed and analyzed the relevant outcomes. Results: The COVID-19 pandemic was found to have a higher transmission rate compared to SARS and MERS and involved 4 stages of evolution. The basic reproduction number (R 0) is 3.32 (95% CI:3.24-3.39), the incubation period was 5.24 days (95% CI:3.97-6.50, 5 studies) on average, and the average time for symptoms onset varied by countries. Common clinical spectrums identified included fever (38.1-39.0°C), cough and fatigue, with Acute Respiratory Distress Syndrome (ARDS) being the most common complication reported. Body temperatures above 39.0°C, dyspnea, and anorexia were more common symptoms in severe patients. Aged over 65 years old, having co-morbidities, and developing complications were the commonest high-risk factors associated with severe conditions. Leucopenia and lymphopenia were the most common signs of infection while liver and kidney damage were rare but may cause bad outcomes for patients. The bilateral, multifocal Ground-Glass Opacification (GGO) on peripheral, and the consolidative pulmonary opacity were the most frequent CT results and the tendency of mortality rates differed by region. Conclusions: We provided a bird's-eye view of the COVID-19 during the current pandemic, which will help better understanding the key traits of the disease. The findings could be used for disease's future research, control and prevention.

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“…In a report from the Middle East (Saudi Arabia)[39] that included 150 hospitalized adult patients (mean age 46.1 years), it was found that 28.8 and 26.0% of the COVID-19 population had hypertension and diabetes, respectively. The asthma prevalence was 2.7%, and 1 patient with asthma was admitted to the ICU.…”

Section: Methodsmentioning

confidence: 99%

Asthma and the Coronavirus Disease 2019 Pandemic: A Literature Review

Morais‐Almeida

Pité

Aguiar

et al. 2020

Int Arch Allergy Immunol

106

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Even though respiratory viruses are one of the most common triggers for asthma exacerbations, not all of these viruses affect patients equally. There is no strong evidence supporting that patients with asthma have a higher risk of becoming seriously ill from coronavirus disease 2019 (CO-VID-19), although recent reports from the USA and the UK suggest that asthma is much more common in children and adults with mild to severe COVID-19 than has previously been reported in Asia and in Europe. As in previous severe acute respiratory syndrome (SARS) outbreaks, patients with asthma, especially children, appear to be less susceptible to the coronavirus with a low rate of asthma exacerbations. A different expression of viral receptors and T2 inflammation can be responsible for different outcomes. Future studies focused on asthma and on other allergic disorders are needed to provide a greater understanding of the impact of underlying asthma and allergic inflammation on COVID-19 susceptibility and disease severity. However, for the moment, it is crucial that asthmatic patients maintain their controller medication, from inhaled corticosteroids to biologics, without making any dose adjustments on their own or stopping the medication. New data are emerging daily, rapidly updating our understanding of this novel coronavirus.

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“Clinical, Radiological and Therapeutic Characteristics of Patients with COVID-19 in Saudi Arabia”

Cited by 22 publications

References 28 publications

Epidemiologic, Clinical, and Laboratory Findings of the COVID-19 in the current pandemic: Systematic Review and Meta-analysis

Epidemiologic, Clinical, and Laboratory Findings of the COVID-19 in the current pandemic: Systematic Review and Meta-analysis

Epidemiologic, clinical, and laboratory findings of the COVID-19 in the current pandemic: systematic review and meta-analysis

Asthma and the Coronavirus Disease 2019 Pandemic: A Literature Review

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