Clinical, radiological and morphological spectrum of squamous cell carcinoma

Abstract

Background: Squamous cell carcinoma is malignancy of the squamous epithelial lining. it has been a major cause of morbidity and mortality worldwide as well as in Indian population. This study was undertaken to analyse the spectrum of squamous cell carcinoma cases presenting at G.G.G. Hospital, Jamnagar to understand the clinical presentation, morphological patterns and anatomical site distribution pattern of squamous cell carcinoma lesions. Materials and Methods: Over a 2-year period, 115 cases were retrieved from the files of cytopathology and histopathology laboratory, Department of Pathology and Radiology of M. P. Shah. Government Medical College, Jamnagar. Results: Out of total 115 cases, maximum cases-103 (89.56 %) were of squamous cell carcinoma. The incidence was observed to be high in >40 years of age. In our institute, we studied total 115 cases of various sites which were diagnosed as squamous cell carcinoma. Of these 115 cases, 47 (40.86%) cases were of lung, 57 (49.46%) cases were of metastasis of Squamous cell carcinoma to lymphnode with maximum 31 (54.38%) cases presented to us as unknown primary. In our study 11 cases involving miscellaneous sites such as oral cavity, lip, cheek, midline neck, pre-auricular region, anterior chest wall and umbilical region, were presented as primary, metastasis and recurrence. Conclusion: Correlation spectrum of morphology, clinical presentation and radiological examination of squamous cell carcinoma with its cytological and histopathological features are important tools to predict prognosis and to facilitate the diagnosis of squamous cell carcinoma and diagnostic dilemma can be prevented.