Clinical, radiological and histological evaluation of biphasic calcium phosphate bioceramic wedges filling medial high tibial valgisation osteotomies

Rouvillain, J.-L.; Lavallé, F.; Pascal-Mousselard, H.; Catonné, Yves; Daculsi, Guy

doi:10.1016/j.knee.2008.12.015

Cited by 34 publications

(19 citation statements)

References 11 publications

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“…This is in agreement with the study reported by Rouvillain et al [26] that showed the same image characteristic even after 18 months of the implantation of BCP (60% HA/40% β -TCP) wedges in high tibial valgisation osteotomies. These authors gave evidences of a resorption rate corresponding to more than 60% of the bioceramics after 2 years and demonstrated that the high radiopacity was due to the greater mineral concentration and the composite formed by the new bone tissue and the residual granules and not due to the nonresorption of the biomaterial [26]. Our good results are in agreement with those reported by others [27].…”

Section: Discussionsupporting

confidence: 93%

Biphasic Calcium Phosphate Bioceramics for Orthopaedic Reconstructions: Clinical Outcomes

Garrido

Lobo

Turíbio

et al. 2011

International Journal of Biomaterials

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BCP are considered the most promising biomaterials for bone reconstruction. This study aims at analyzing the outcomes of patients who received BCP as bone substitutes in orthopaedic surgeries. Sixty-six patients were categorized according to the etiology and morphology of the bone defects and received scores after clinical and radiographic evaluations. The final results corresponded to the combination of both parameters and varied from 5 (excellent result) to 2 or lower (poor result). Most of the patients who presented cavitary defects or bone losses due to prosthesis placement or revision, osteotomies, or arthrodesis showed good results, and some of them excellent results. However, patients with segmental defects equal or larger than 3 cm in length were classified as moderate results. This study established clinical parameters where the BCP alone can successfully support the osteogenic process and where the association with other tissue engineering strategies may be considered.

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Section: Discussionsupporting

confidence: 93%

Biphasic Calcium Phosphate Bioceramics for Orthopaedic Reconstructions: Clinical Outcomes

Garrido

Lobo

Turíbio

et al. 2011

International Journal of Biomaterials

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“…Macropores are beneficial for bone ingrowth and vascularization, while micrometric features such as micropores and topography promote cell adhesion. A combination of macro‐ and microporosity has been shown to be critical for cellular infiltration and nutrient and waste transport and to produce positive clinical results . A summary of the effect of BCP particle size, composition and microstructure of BCPs on bone formation both in vitro and in vivo is presented in Table .…”

Section: Preclinical Investigations—in Vivomentioning

confidence: 99%

“…A combination of macro-and microporosity has been shown to be critical for cellular infiltration and nutrient and waste transport and to produce positive clinical results. [150][151][152] A summary of the effect of BCP particle size, composition and microstructure of BCPs on bone formation both in vitro and in vivo is presented in Table II.…”

Section: Microstructure Of Bcpsmentioning

confidence: 99%

Hydoxyapatite/beta‐tricalcium phosphate biphasic ceramics as regenerative material for the repair of complex bone defects

2017

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Bone is a composite material composed of collagen and calcium phosphate (CaP) mineral. The collagen gives bone its flexibility while the inorganic material gives bone its resilience. The CaP in bone is similar in composition and structure to the mineral hydroxyapatite (HA) and is bioactive, osteoinductive and osteoconductive. Therefore synthetic versions of bone apatite (BA) have been developed to address the demand for autologous bone graft substitutes. Synthetic HA (s-HA) are stiff and strong, but brittle. These lack of physical attributes limit the use of synthetic apatites in situations where no physical loading of the apatite occurs. s-HA chemical properties differ from BA and thus change the physical and mechanical properties of the material. Consequently, s-HA is more chemically stable than BA and thus its resorption rate is slower than the rate of bone regeneration. One solution to this problem is to introduce a faster resorbing CaP, such as β-tricalcium phosphate (β-TCP), when synthesizing the material creating a biphasic (s-HA and β-TCP) formulation of calcium phosphate (BCP). The focus of this review is to introduce the major differences between BCP and biological apatites and how material scientists have overcome the inadequacies of the synthetic counterparts. Examples of BCP performance in vitro and in vivo following structural and chemical modifications are provided as well as novel ultrastructural data. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2493-2512, 2018.

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“…Since the first studies of BCP with varying HA/b-TCP ratios, as reviewed by LeGros et al, many others have described various BCP composition ratios. 10,11 The subsequent studies of BCP have led to the use of commercial BCP bioceramics as bone graft materials for dental applications and recent reports suggest that BCPs with higher b-TCP ratio are expected to yield more replacement of biomaterial by new bone. 6,12 However, the osteoconductive effects of commercial BCP bioceramics remain controversial.…”

Section: Introductionmentioning

confidence: 99%

Osteoconductivity and biodegradation of synthetic bone substitutes with different tricalcium phosphate contents in rabbits

et al. 2013

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Various synthetic bone substitutes have been developed to reconstruct the bony defects that clinicians often encounter during surgical procedures. Among various synthetic bone substitutes, calcium phosphate (Ca-P) ceramics have been investigated because their composition and structure are similar to those of human bone. We evaluated the bone healing and biodegradation patterns of three types of Ca-P ceramic particle with various hydroxyapatite (HA)/β-tricalcium phosphate (β-TCP) weight ratio: pure β-TCP, biphasic Ca-P (BCP) with a HA/β-TCP weight ratio of 60/40 (BCP 60/40), and BCP with an HA/β-TCP weight ratio of 20/80 (BCP 20/80). Four 8-mm-diameter defects were created in ten rabbits. Three of the defects in each rabbit were separately and randomly filled with one of the three experimental Ca-P ceramic particles, and the fourth was filled with blood clots (control). The specimens were harvested at 2 and 8 weeks post-surgery. The histologic and histometric findings revealed that the augmented space and new bone formation were significantly better for all three Ca-P ceramics than for the control group at both 2 and 8 weeks (p < 0.05). Compared to the pure β-TCP, the two BCP groups were found to provide a larger amount of newly formed bone and bone density at the 2- and 8-week post-operative periods (p < 0.05). Throughout the observation period, BCP 60/40 and BCP 20/80 exhibited a similar bone healing and biodegradation patterns with regard to both individual particles and the total augmented area in vivo.

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Clinical, radiological and histological evaluation of biphasic calcium phosphate bioceramic wedges filling medial high tibial valgisation osteotomies

Cited by 34 publications

References 11 publications

Biphasic Calcium Phosphate Bioceramics for Orthopaedic Reconstructions: Clinical Outcomes

Biphasic Calcium Phosphate Bioceramics for Orthopaedic Reconstructions: Clinical Outcomes

Hydoxyapatite/beta‐tricalcium phosphate biphasic ceramics as regenerative material for the repair of complex bone defects

Osteoconductivity and biodegradation of synthetic bone substitutes with different tricalcium phosphate contents in rabbits

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