Clinical-radiologic correlation of mixed epithelial and stromal tumor of the kidneys: Cases analysis

Tsai, Sheng‐Han; Wang, Jia-Hwia; Lai, Yi‐Chen; Chang, Yen-Hwa; Chung, Hsiao-Jen; Chang, Luke S.

doi:10.1016/j.jcma.2016.02.012

Cited by 17 publications

(19 citation statements)

References 16 publications

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“…Radiograficamente, o MESTK se apresenta na tomografia computadorizada como massa cística multilocular, com ocasionais calcificações, em geral classificados nas categorias Bosniak III, cujas lesões tem uma chance de 30 a 100% de serem malignas, e a cirurgia é recomendada, ou Bosniak IV, cuja cirurgia é fortemente indicada por tratar-se de lesão maligna até que se prove o contrário. 11 A core-biopsy não é indicada para massas renais císticas, a menos que áreas sólidas estejam presentes. A cirurgia é recomendada na maioria dos casos de MESTK.…”

Section: Discussionunclassified

Tumor epitelial e estromal misto do rim: relato de caso

et al. 2019

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O tumor epitelial e estromal misto do rim é uma neoplasia rara, caracterizada pelo seu padrão histopatológico bifásico, formado por elementos epiteliais e estromais. Predomina no sexo feminino, na perimenopausa e sua patogênese ainda é desconhecida. Relata-se o caso de uma paciente de 54 anos, que iniciou crises recorrentes de dor em flanco direito e disúria. Os exames de imagem evidenciaram lesão cística complexa em rim esquerdo e paciente foi submetida à nefrectomia. O exame histopatológico e a imuno-histoquímica confirmaram o diagnóstico.

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Section: Discussionunclassified

Tumor epitelial e estromal misto do rim: relato de caso

et al. 2019

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“…Therefore, most cases are treated surgically. [ 3 4 ] In this report, we present a case with MESTK treated with laparoscopic radical nephroureterectomy and bladder cuff resection.…”

Section: Introductionmentioning

confidence: 99%

Mixed epithelial and stromal tumor of the kidney treated with minimally invasive surgery

et al. 2020

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Mixed epithelial and stromal tumor of the kidney (MESTK) is a rare kidney tumor that tends to occur in middle-aged and older women and is characterized by a distinctive histological appearance. Most of them were incidentally detected. A 26-year-old female patient was referred to in our clinic due to intermittent left lower back pain for 2 months and left renal mass. Abdominal computed tomography showed a cystic enhanced heterogenic left renal mass about 5 cm in the largest diameter was extending from the renal pelvis to the ureter and causing gross hydronephrosis of the left kidney. The mass treated with transperitoneal laparoscopic nephroureterectomy and bladder cuff resection. Histopathological evaluation revealed MESTK. In our patient, MESTK successfully and without any complication be treated by minimally invasive surgery. We believe that the fact that the tumor can mimic the urothelial-cell carcinoma of the kidney in radiological appearance, as seen in our case, should be taken into consideration.

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“…2 Rare cases of bilateral MEST have been reported suggesting the possibility of a germline genetic component. [4][5][6] Hyperparathyroidism-jaw tumor syndrome (HPT-JT) is a hereditary syndrome first described by Jackson et al 7 and is clinically and genetically distinct from the multiple endocrine neoplasia syndromes. In addition to hyperparathyroidism in 80% of affected patients, 30%-50% of patients develop fibro-osseous lesions of the mandible and maxilla, and 10%-15% develop parathyroid carcinoma.…”

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confidence: 99%

“…5 Tsai et al reported one case of bilateral MEST, but no genetic analysis was performed in that study. 6 Germline mutation of CDC73 is strongly associated with HPT-JT and the clinical manifestations of HPT-JT are relatively well known. [8][9][10] This study suggests that a differential diagnosis of MEST should be considered in HPT-JT patients with germline CDC73 mutations who exhibit kidney lesions.…”

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confidence: 99%