Clinical protocols for oral anticoagulant reversal during high risk of bleeding for emergency surgical and nonsurgical settings: a narrative review

Proximal femur fractures in patients taking anti-coagulants: has anything changed?

“…Furthermore, prior to invasive procedures, DOACs should not be reversed unless the bleeding risk associated with the procedure is sufficiently high when balanced with the risk of prothrombotic events and high costs. (Andexanet alfa costs £11,100/pack in the UK and $5500 per 200 mg vial in the United States, whereas Idarucizumab costs £2400 per 5 g and $3500 per 5 g kit, respectively) ( 52 , 56 , 57 ).…”

Anesthetic challenges in ruptured ovarian cyst with supratherapeutic international normalized ratio in patient a with artificial mitral valve

“…The anticoagulant effects of vitamin K antagonist are reversed by 4-factor prothrombin complex concentrates, vitamin K followed by FFP as the second line of treatment. [ 2 ] In emergency conditions, vitamin K and FFP are always immediately available. The authors have successfully managed a case of massive hemorrhage due to a ruptured ovarian cyst in an anticoagulated patient with an artificial mitral valve by using FFP in emergency surgery.…”