Clinical Progress Note: Procalcitonin in the Management of Pediatric Lower Respiratory Tract Infection

Katz, Sophie; Sartori, L.; Williams, Derek J.

doi:10.12788/jhm.3301

Cited by 5 publications

(3 citation statements)

References 17 publications

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“…Some biological indicators help to predict the pathogen categories of infectious diseases. Procalcitonin and C-reactive protein were considered to be biomarkers of bacterial infection in LRTI ( Katz, Sartoni & Williams, 2019 ; Schuetz et al, 2017 ; IIrwin et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Distribution characteristics of serum β2-microglobulin between viral and bacterial lower respiratory tract infections: a retrospective study

Cai¹,

Xu²,

Zhou³

et al. 2020

PeerJ

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Background Lower respiratory tract infection (LRTI) is one of the leading cause of death in children under 5 years old around the world between 1980 and 2016. Distinguishing between viral and bacterial infection is challenging when children suffered from LRTI in the absence of pathogen detection. The aim of our study is to analyze the difference of serum β2-microglobulin (β2-MG) between viral LRTI and bacterial LRTI in children. Methods This retrospective study included children with LRTI caused by a single pathogen from Yancheng Third People’s Hospital, Yancheng, China, between January 1, 2016 and December 31, 2019. Participants were divided into the younger group (1 year old ≤ age < 3 years old) and the older group (3 years old ≤ age < 5 years old) for subgroup analysis. Results A total of 475 children with LRTI caused by common respiratory pathogens were identified. In the younger group as well as the older group, the serum level of β2-MG in respiratory syncytial virus, influenza A virus and influenza B virus groups were significantly increased compared to that in the Mycoplasma pneumoniae group. Compared with Streptococcus pneumoniae infection group, the serum β2-MG level of respiratory syncytial virus, influenza A virus and influenza B virus groups were significantly higher in children between 1 and 3 years old. Conclusions The serum β2-MG may distinguish viral infection from bacterial infection in children with LRTI.

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Section: Introductionmentioning

confidence: 99%

Distribution characteristics of serum β2-microglobulin between viral and bacterial lower respiratory tract infections: a retrospective study

Cai¹,

Xu²,

Zhou³

et al. 2020

PeerJ

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show abstract

“…In addition to pathogen detection, biomarker detection can also help to screen the categories of infectious pathogens. C-reactive protein and procalcitonin are used as bacterial biomarkers to identify bacterial infection and guide the use of antibiotics ( Irwin et al, 2017 ; Katz, Sartori & Williams, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Serum β2-microglobulin may be a viral biomarker by analyzing children with upper respiratory tract infections and exanthem subitum: a retrospective study

Cai

Zhou

et al. 2021

PeerJ

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Background Due to the lack of effective and feasible viral biomarkers to distinguish viral infection from bacterial infection, children often receive unnecessary antibiotic treatment. To identify serum β2-microglobulin that distinguishes bacterial upper respiratory tract infection from viral upper respiratory tract infection and exanthem subitum in children. Methods This retrospective study was conducted from January 1, 2019 to September 30, 2020 in Yancheng Third People’s Hospital. Children with upper respiratory tract infection and exanthem subitum were recruited. The concentration of serum β2-microglobulin in the viral and bacterial infection groups were statistically analyzed. Results A total of 291 children included 36 with bacterial upper respiratory tract infection (median age, 13 months; 44.4% female), 197 with viral upper respiratory tract infection (median age, 12 months; 43.7% female) and 58 with exanthem subitum (median age, 13 months; 37.9% female). When the concentration of β2-microglobulin was 2.4mg/L, the sensitivity to distinguish viral from bacterial upper respiratory tract infection was 81.2% (95% CI [75.1–86.4%]), and the specificity was 80.6% (95% CI [64.0–91.8]%). When the cutoff was 2.91 mg/L, the sensitivity of β2-microglobulin to distinguish exanthem subitum from bacterial upper respiratory tract infection was 94.8% (95% CI [85.6–98.9]%), and the specificity was 100% (95% CI [90.3–100]%). Conclusions Serum β2-microglobulin may be a significant biological indicator in children with upper respiratory tract infection and exanthem subitum.

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“…Procalcitonin is an inflammatory biomarker that can be readily tested for and is currently offered by many clinical laboratories. Commonly ordered as PCT, it was initially approved for use in the setting of acute bacterial infections in the United States by the FDA in 2017 for diagnosis of lower respiratory tract infections (Katz et al, 2019). PCT testing helps to determine the probability of a bacterial infection turning into a sepsis event and aids in the selection and cessation of antibiotics in these situations.…”

Section: Introductionmentioning

confidence: 99%

PCT testing in sepsis protocols

Valencia

2023

Front. Anal. Sci.

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Septicemia is a prominent disease with a mortality rate of over 20%, making it one of the most expensive illnesses for hospitals in the United States. Many cells throughout the body release procalcitonin (PCT) in response to severe bacterial infection. This literature review attempts to assess PCT testing as a potential addition to sepsis protocols and to identify recommendations when implementing PCT testing into sepsis workups. The incorporation of PCT testing could significantly reduce the financial burden, antibiotic usage, and mortality rates in sepsis cases.

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Clinical Progress Note: Procalcitonin in the Management of Pediatric Lower Respiratory Tract Infection

Cited by 5 publications

References 17 publications

Distribution characteristics of serum β2-microglobulin between viral and bacterial lower respiratory tract infections: a retrospective study

Distribution characteristics of serum β2-microglobulin between viral and bacterial lower respiratory tract infections: a retrospective study

Serum β2-microglobulin may be a viral biomarker by analyzing children with upper respiratory tract infections and exanthem subitum: a retrospective study

PCT testing in sepsis protocols

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