Abstract:A ccording to the most recent Annual Report of the American Association of Poison Control Centers' National Poison Data System, there were 51,081 patient exposures to acetaminophen or acetaminophen-containing products treated in a healthcare facility in 2018. 1 The toxicity of acetaminophen is mediated by its metabolism into the electrophile N-acetyl-p-benzoquinone imine (NAPQI). 2 If the amount of acetaminophen ingested is higher than recommended dosages, glutathione stores may become depleted as the liver tr… Show more
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