Clinical Prognostic Factors and Survival Outcome in Renal Cell Carcinoma Patients - A Malaysian Single Centre Perspective

Yap, Ning Yi; Ng, Keng Lim; Ong, Teng Aik; Pailoor, Jayalakshmi; Gobé, Glenda C.; Ooi, Chong Chien; Razack, Azed Hassan; Dublin, Norman; Morais, Christudas; Rajandram, Retnagowri

doi:10.7314/apjcp.2013.14.12.7497

Cited by 18 publications

(15 citation statements)

References 18 publications

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“…stádiumban volt. A hypoalbuminaemia rosszabb betegségmentes túléléssel korrelált a stádiumra illesztve (HR 3,00 [CI 0,99-8,87], p = 0,051) [36]. Egy emlőrákban (BC) végzett vizsgálat szerint 169 esetben nézték az albuminszinteket.…”

Section: Eredményekunclassified

Az albumin prognosztikai jelentősége az onkológiában

Deme¹,

Telekes

2018

Orvosi Hetilap

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A szérumalbuminszint csökkenése figyelhető meg gyulladásos folyamatokban. A helyileg előrehaladott vagy áttétes rosszindulatú daganatokban a szérumalbuminszint ugyancsak csökken, az alultápláltság fennállásától függetlenül. A csökkent albuminszint befolyásolhatja a terápia eredményeit is (például gyógyszerek farmakokinetikája, mellékha-tások mértéke). Kiterjedt szakirodalmi adat és gyakorlati tapasztalat bizonyítja a táplálásterápiában részesülő pácien-sek jobb prognózisát. A szerzők a fontosabb szakirodalmi adatok alapján összefoglalják azon vizsgálatokat, melyek a kiindulási szérumalbuminszint és a rosszindulatú daganatos betegségek prognózisa közötti szoros összefüggést feltárták. Orv Hetil. 2018; 159(3): 96-106. Kulcsszavak: albumin, rosszindulatú daganatok, prognózis Prognostic importance of albumin in oncologyDiminished serum albumin level can be observed in inflammatory processes. Serum albumin level also reduces -irrespective of the presence of malnutrition -in locally advanced or metastatic malignancies. Low serum albumin level may have an influence also on the results of anticancer therapy (e.g., drug pharmacokinetics, adverse drug reactions). Extensive data of the literature and empirical experience prove the better prognosis of patients involved in nutritional therapy. Based on the most relevent data of the literature, the authors summarize the studies which have revealed the close correlation between the baseline serum albumin level and the prognosis of malignant diseases. Rövidítések ALI = (advanced lung cancer inflammation index) előrehala-dott tüdőrák index; APACHE = (acute physiology and chronic health evaluation) heveny élettani és idült egészség értékelés; BC = (breast cancer) emlőrák; BMI = (body mass index) testtömegindex (kg/m 2 ); CI = konfidenciaintervallum; CRC = (colorectal cancer) vastag-és végbélrák; CRP = C-reaktív protein; CRPC = (castration-resistant prostate cancer) kasztráció-rezisztens prostatarák; CSS = (cancer specific survival) daganatspecifikus túlélés; DFS = (disease-free survival) betegségmentes túlélés; DNS = dezoxiribonukleinsav; DSS = (disease-specific survival) betegségspecifikus túlélés; GPS = (Glasgow Prognostic Score) Glasgow prognosztikai pontrendszer; HCC = (hepatocellular carcinoma) primer májrák; HR = (hazard ratio) kockázati hányados; IL = interleukin; IMA = ischaemiamódosított albumin; IPI = (inflammatory prognostic index) gyulladásos prognosztikai index; KPS = Karnofsky Performance Status; LDH = (lactate dehydrogenase) laktátdehidrogenáz; LMR = (lymphocyte-monocyte ratio) abszolút lymphocyta-monocyta arány; mGPS = (modified Glasgow Prognostic Score) módosí-tott Glasgow prognosztikai pontrendszer; mGPS 0, 1, 2 = a módosított Glasgow prognosztikai pontrendszer értékei 0, 1, 2; MSKCC = Memorial Sloan Kettering Cancer Center; nabpaclitaxel = nanopartikuláris albuminhoz kötött paclitaxel; NLR = (neutrophil-lymphocyte ratio) abszolút neutrophillym phocyta arány; NRS = (nutritional risk screening) tápláltsá-gi kockázatszűrés; NSCLC = (non-small cell lung cancer) nem...

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Section: Eredményekunclassified

Az albumin prognosztikai jelentősége az onkológiában

Deme¹,

Telekes

2018

Orvosi Hetilap

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“…In addition, there is evidence showing that epigenetic events play important roles in the metastasis of RCC Bernstein et al, 2005;Carninci et al, 2005;Drewell et al, 2002;Kern et al, 2007;Sessa et al, 2007). It has been confirmed that expression of LncRNAs is closely related to the occurrence and metastasis of multiple malignancies (van Herpen et al, 2002;Yap et al, 2013). HOTAIR is a type of LncRNA that mediates numerous processes in cancer metastasis via epigenetic modifications, and thus is closely associated with the occurrence and development of cancers (Zhang et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Influence of Curcumin on HOTAIR-Mediated Migration of Human Renal Cell Carcinoma Cells

Pei¹,

Wu²,

Fan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…In the study of 151 RCC cases conducted by Yap et al (15) and published in 2014, 11.6% of the patients were reported as G1, 52.6% as G2, 25.3% as G3, and 10.5% as G4. The difference among the rates was explained by noncompliance among the evaluators.…”

Section: Discussionmentioning

confidence: 99%

General Overview of Renal Cell Carcinoma with the Evaluation of our cases

Yıldız¹,

Sönmez²,

Büyükpınarbaşılı³

et al. 2015

Bezmialem Science

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Objective: Renal cell carcinoma (RCC) is the 14 th most common tumor in the world. In 2010, the protocol for the examination of kidney specimens with invasive carcinoma of renal tubular origin was updated. The aim of our study was to review 1-year RCC patients of our hospital according to the new protocol, classification, and staging systems with respect to their morphological and immunohistochemical features. Methods: The medical records of 54 RCC patients between July 2012 and July 2013 were retrospectively reviewed. They were classified according to the WHO 2004 classification system and newly defined subtypes. The following variables were determined in each case: age, sex, histological subtype, stage, and Fuhrman nuclear grade. Results: In our study, 30 (55.6%) men and 24 (44.4%) women were diagnosed with RCC out of 54 patients. The median age was 56 years. In total, 21 patients had (55.2%) right-and 17 had (44.74%) left-sided tumors. Thirty-eight (70.3%) clear cell, 6 (11.1%) papillary, 7 (12.96%) chromophobe, 1 (1.85%) multilocular, 1 (1.85%) unclassified, and 1 (1.85%) tubulocystic RCC were seen. According to primary tumor, 33 (61.1%) pT1, 10 (18.51%) pT2, 9 (16.66%) pT3, and 2 (3.70%) pT4 patients were reported. Chromophobe RCCs were excluded from the Fuhrman grading (G) system; of the remaining 2 (4.17%) were G1, 30 (62.5%) were G2, 13 (27.08%) were G3, and 3 (6.25%) were G4 tumors. Conclusion: Although RCC constitutes the majority of renal tumors, different subtypes are also encountered. In our study, clear cell RCCs were the most common type of tumors consistent with the literature. The remarkable point was that chromophobe RCCs were more frequent in our study. Because of infrequency, more examples are required to distinguish newly defined subtypes.

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Clinical Prognostic Factors and Survival Outcome in Renal Cell Carcinoma Patients - A Malaysian Single Centre Perspective

Cited by 18 publications

References 18 publications

Az albumin prognosztikai jelentősége az onkológiában

Az albumin prognosztikai jelentősége az onkológiában

Influence of Curcumin on HOTAIR-Mediated Migration of Human Renal Cell Carcinoma Cells

General Overview of Renal Cell Carcinoma with the Evaluation of our cases

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