Clinical profiling of patients with Acid Peptic Disorders (APD) in India: a cross-sectional survey of clinicians

Roop, Ramesh; Gangadhar, A.; Mayabhate, Mayur M.

doi:10.18203/2319-2003.ijbcp20164779

Cited by 7 publications

(8 citation statements)

References 19 publications

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“…The major age group was 31 to 40 years (50%) in this study which is consistent with other studies done by Abdihamid Mohamed Ali et al 1 But some other studies showed that the prevalence of peptic ulcer disease increases with ages (>60 y). 2,3,15 In this study we found males (58.66%) were more predominant in PUD than females (41.33%). Male predominance is attributed to cigarette smoking.…”

Section: Discussionsupporting

confidence: 50%

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Clinical Characteristics of Peptic Ulcer Disease & its Pharmacological Management in Primary Care

Alam

Islam

2023

Mediscope

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Background: Peptic ulcer diseases (PUD) are common conditions reported in daily clinical practice. Proton pump inhibitors (PPIs) are the most potent pharmacological inhibitors of gastric acid secretion. Aims & objectives: This study aimed to evaluate & understand the clinical presentation and management of PUD with PPIs in general practice. Methods: This prospective study was conducted on 150 diagnosed cases of PUD patients in a single center of private practice in rural areas from February 2022 to August 2022. Patients were enrolled by following inclusion & exclusion criteria with informed written consent. Eight (08) weeks after the completion of treatment by giving PPIs, a repeat endoscopy was done to see the improvement of healing of the ulcer. All data were collated and results were expressed in percentages which are illustrated in different tables & figures. Results: Among 150 endoscopically diagnosed PUD patients major age group was 31-40 years (50%) of both sexes where the male (58.66%) were more predominant. Abdominal pain (82%), heartburn (56.66%), etc were the main clinical symptoms of the patients who were referred for endoscopy. After confirming the diagnosis, PPIs were given to the patients. Esomeprazole (34.66%), lansoprazole (22%), pantoprazole (18.66%), etc were prescribed frequently. After 8 weeks of treatment, repeat endoscopy revealed that the ulcer was completely healed in 65.33% of patients whereas only 6.66% had no improvement. Conclusion: The majority of the patient are almost cured of PUD by receiving various types of PPIs which are very effective drugs for healing peptic ulcer disease. Mediscope 2023;10(1): 22-30

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Section: Discussionsupporting

confidence: 50%

“…Similar findings were found in other studies. [1][2][3]5,6,14,15 As the study was done in peripheral settings so maximum number of patients (58.66%) came from rural areas. Their socioeconomic status remains in the medium category (54.66%).…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Peptic Ulcer Disease & its Pharmacological Management in Primary Care

Alam

Islam

2023

Mediscope

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“…Most common clinical presentation in our study was epigastric pain and /or burning (36%) followed by epigastric discomfort (35%) and upper gastrointestinal bleed (29%). In a study by Ramesh Roop Rai et al [16], epigastric pain/discomfort was seen in 72.3% of the patient with peptic ulcer disease. In study by khuroo et al 24 % patients presented with GI bleed [9].…”

Section: Discussionmentioning

confidence: 95%

Clinical Profile and Risk Factors for Benign Peptic Ulcer Disease in a Tertiary Care Centre in the Subhimalayan Ranges of North India

Bodh

Sharma

2020

PIJR

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Background: To study the clinical profile and risk factors for benign peptic ulcer disease. Material and Methods: A total of 200 patients of peptic ulcer disease (PUD) diagnosed on upper gastrointestinal endoscopy were included. The socio-demographic profile, risk factors, clinical and endoscopic findings were recorded. Results: A total of 200 patients of peptic ulcer disease were included, out of which 168(84%) were males, while 32 (16%) were females. Most of the patients (61%) were between age 31-60 years with mean age of 47 years. Most of patients were farmers from rural areas and belonged to low socioeconomic status. History of smoking and alcohol intake was present in 106(53%) and 70( 35 %) patients respectively.Most common presenting complaints were epigastric pain and/or burning in 72 (36%) , followed by upper abdomen discomfort 70(35%) and upper gastrointestinal bleed 58(29%). Duodenal ulcer (DU) was present in 152 (76%), gastric ulcer(GU) in 30 (15%) while 18 (9%) had both DU and GU. Most of the patients had Forrest III ulcer 167 (83.5%) followed by Forrest IIc ulcer 13 (6.5%). H. pylori was detected by rapid urease test on endoscopic biopsy specimen in 156 (78 % ) of the total 200 patients of peptic ulcer disease. H. pylori was detected in 78.94 % case of DU, 60% case of GU and 100% cases of both DU and GU. Conclusion: PUD is a multifactorial health problem affecting almost all populations worldwide. . The major risk factors associated with PUD included tobacco and alcohol consumption besides low socioeconomic status, rural background and occupation of farming. Our findings indicate the substantial role of H. pylori and painkiller ingestion in the pathogenesis of PUD. Duodenal ulcer is most common type followed by gastric ulcer. Most had Forrest III ulcer followed by Forrest IIc.

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“…Pharmacologic treatment of acid peptic disorders has focused on correcting this imbalance by either improving mucosal defences with drugs such as sucralfate, bismuth, and prostaglandin analogs, neutralizing acid with antacids, or decreasing acid secretion with histamine-2 (H2)-receptor antagonists, or, more recently, proton pump inhibitors. (2) The exact frequency of dyspepsia in the general population is difficult to find out because many individuals who have the symptoms do not seek medical care. Of all adults 30-40% experience symptoms of upper abdominal pain or discomfort but an organic cause is found in only a minority who seek medical care.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors of Acid Peptic Disease Among Adults Attending the General Medicine Outpatient Department of a Tertiary Care Institution in South India- A Cross Sectional Study

S¹,

Rasheed²,

Menon³

et al. 2018

jemds

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BACKGROUND Acid Peptic Disease is a condition which is widely prevalent among adults. Several individuals especially belonging to the age groups of senior citizens are found to be suffering from this condition. It may manifest as heart burn, nausea, a feeling of gaseous distension of abdomen, decreased appetite, irritability etc. Frequent suffering from these problems will affect the quality of life of the person considerably. Abstaining from certain foods regularly for avoiding the symptoms of this condition may affect the nutritional status of the elderly. On the other hand, young adults may find their work capacity and concentration in work and studies affected by this. Thus, Acid Peptic Disease is an ailment, even though not causing much mortality, can result in considerable morbidity. With an understanding regarding the risk factors of Acid Peptic Disease, life style modifications can be brought about, which can reduce the distress associated with this condition. Aim of the Study-To evaluate the risk factors for developing acid peptic disease among adults visiting the different departments of Travancore Medical College during the study period. MATERIALS & METHODS This was a cross sectional study done in Travancore Medical College, which is a tertiary level hospital and teaching institution in Kollam, Kerala. Adults attending the general medicine outpatient department of this medical college were included in the study. A total of 237 subjects were studied. RESULTS Statistically significant association was found for consumption of spicy foods (p value<0.001), Non-Steroidal Anti-inflammatory Drugs (p value<0.01), intake of hot food and beverages (p value<0.01), smoking (p value<0.001), alcohol (p value<0.001) and emotional stress (p value<0.0.005) in this study. Regularity of food intake, BMI, regular physical exercise, frequent intake of coffee/tea or vegetarian/non-vegetarian food habits did not show statistically significant association in this study. CONCLUSION Among the various risk factors considered to be associated with acid peptic disease, hot & highly spicy food, emotional stress, smoking, alcoholism and intake of NSAIDs were significantly related to acid peptic disease in this study group. It follows that a control of these factors by awareness creation supplemented with drugs could bring about considerable improvement in the quality of life of the patients.

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Clinical profiling of patients with Acid Peptic Disorders (APD) in India: a cross-sectional survey of clinicians

Cited by 7 publications

References 19 publications

Clinical Characteristics of Peptic Ulcer Disease & its Pharmacological Management in Primary Care

Clinical Characteristics of Peptic Ulcer Disease & its Pharmacological Management in Primary Care

Clinical Profile and Risk Factors for Benign Peptic Ulcer Disease in a Tertiary Care Centre in the Subhimalayan Ranges of North India

Risk Factors of Acid Peptic Disease Among Adults Attending the General Medicine Outpatient Department of a Tertiary Care Institution in South India- A Cross Sectional Study

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