Clinical Profile, Viral Load, Maternal-Fetal Outcomes of Pregnancy With COVID-19: 4-Week Retrospective, Tertiary Care Single-Centre Descriptive Study

Abstract

Introduction The COVID19 pandemic raises a major concern about its severity in pregnancy, fetomaternal outcomes and risk of vertical transmission.The Cycle threshold indicating the viral load can be a contributory factor towards modifying the management of such pregnant women. We report a retrospective descriptive study regarding the clinical course, fetomaternal outcomes of pregnant women with COVID19. Methodology This is a single-center, retrospective study performed in a tertiary care hospital for pregnant women with COVID-19 in India. The medical records of the all women who delivered in the Covid facility from May 5th 2020 to June 5th 2020 were reviewed independently. Data extracted from the records included demography, obstetric details, co morbidities, disease severity, investigations, management and information on neonates (birthweight, Apgar score, and perinatal complications).Statistical analysis was performed by the SPSS program for Windows, version 17.0(SPSS, Chicago, Illinois) Results Amongst 348 women(suspects) tested for SARS-CoV-2, 57 women ( 57/348,16.3%) were confirmed positive based on qRT-PCR of nasopharyngeal specimen. Most women (45 /78.9 %) had mild infection with favourable fetomaternal outcomes. Three maternal mortalities were associated with co morbidities. Five neonates tested positive for SARS-CoV-2, remained haemodynamically stable and were subsequently discharged. Conclusions Majority of pregnant women with Covid-19 had mild disease and recovered subsequently with good perinatal outcomes. Women with co morbidities may have increased risk of severe morbidity and mortality.The Cycle threshold signifying the viral load and degree of infectivity can modify the management during pregnancy.Long-term outcomes and the potential mother-to-child vertical/horizontal transmission needs further study.

Demographic profile of COVID-19 positive mothers & their outcome in government Rajaji hospital, Madurai, Tamilnadu – A cross sectional Study

“…The overall mean age of our study population was 25.98 (S.D ± 4.35) and median maternal was 26 years (Interquartile range [IQR] 23–29) which was similar to Indian study done by Bachani et al 13 and lower than the systematic review done by Anna Nunzia Della et al with median of 30 years (interquartile range [IQR], 27.5–33). 25 Studies by G. Kayem et al 26 and Brandt JS et al 27 stated that advanced maternal age is a risk factor for COVID19 outcome during pregnancy.…”

“… 24 Pregnancy Induced Hypertension (31.37%) was the commonest comorbidity found among the study population but study by Mullins et al 12 done from UK pregnancy registry showed that Gestational Diabetes Mellitus (9.7%) was most common comorbidity recorded. Study by Bachani et al 13 showed anemia, hypertension disorder and thrombocytopenia as common comorbidity.…”

“…Several other studies also had similar findings. Bachani et al 13 states that 45 (78.9%) pregnant women had low grade fever, cough and diarrhoea. Anna et al states that 17 (48%)pregnant women presented with fever at hospital admission and 16 (46%) women indicated dry cough (either alone or associated with any other symptom).…”

“… 11 There is limited data and research done regarding maternal and perinatal outcome in COVID19 affected women globally, done in developed & developing countries. 12 , 13 In order to gain more knowledge of COVID19 outcomes in pregnancy and for better understanding of this newly emerging disease this descriptive cross-sectional study was done. The objective of this study was to describe the demographic profile of COVID-19 positive mothers admitted in Government Rajaji hospital, Madurai in terms of time, place and person and to assess the general and pregnancy outcome of the study population.…”

SARS-CoV-2—Morphology, Transmission and Diagnosis during Pandemic, Review with Element of Meta-Analysis

“… Forest plots estimating the odd ratios of infection in vaginal birth and caesarean birth [ 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 , 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 204 , 205 , 206 , 207 , 208 , 209 , 210 , 211 , 212 , 213 , 214 , 215 , 216 , 217 , 218 , 219 , 220 , 221 , 222 , 223 , 224 , …”