Clinical profile of Trypanosoma cruzi infection in a non-endemic setting: Immigration and Chagas disease in Barcelona (Spain)

Muñóz, José; Prat, Jordi; Gállego, Montserrat; Gimeno, Fausto; Treviño, Begoña; López-Chejade, Pablo; Ribera, Oriol; Molina, Lluís; Sanz, Sergi; Pinazo, María Jesús; Riera, Cristina; Posada, Elizabeth; Sanz, Ginés; Portús, Montserrat; Gascón, Joaquim

doi:10.1016/j.actatropica.2009.02.005

Cited by 100 publications

(107 citation statements)

References 17 publications

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“…The parasite was first identified by the Brazilian infectologist Carlos Chagas in 1909, but it was not until the 1960s that disease control programs were first established (ABAD FRANCH et al 2011;DIAS 2009;SILVEIRA 2002). Rural migration to urban areas in the 1960s and the 1970s increased the risk of contracting the disease, while recent large-scale migration has led to the further spread of the disease to a number of other countries worldwide (GASCON et al 2010;MUÑOZ et al 2009;JACKSON et al 2010). …”

Section: Introductionmentioning

confidence: 99%

Scientific authorships and collaboration network analysis on Chagas disease: papers indexed in PubMed (1940-2009)

González‐Alcaide

Park

Huamaní

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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SUMMARYChagas disease is a chronic, tropical, parasitic disease, endemic throughout Latin America. The large-scale migration of populations has increased the geographic distribution of the disease and cases have been observed in many other countries around the world. To strengthen the critical mass of knowledge generated in different countries, it is essential to promote cooperative and translational research initiatives. We analyzed authorship of scientific documents on Chagas disease indexed in the Medline database from 1940 to 2009. Bibliometrics was used to analyze the evolution of collaboration patterns. A Social Network Analysis was carried out to identify the main research groups in the area by applying clustering methods. We then analyzed 13,989 papers produced by 21,350 authors. Collaboration among authors dramatically increased over the study period, reaching an average of 6.2 authors per paper in the last five-year period. Applying a threshold of collaboration of five or more papers signed in co-authorship, we identified 148 consolidated research groups made up of 1,750 authors. The Chagas disease network identified constitutes a "small world," characterized by a high degree of clustering and a notably high number of Brazilian researchers.

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Section: Introductionmentioning

confidence: 99%

Scientific authorships and collaboration network analysis on Chagas disease: papers indexed in PubMed (1940-2009)

González‐Alcaide

Park

Huamaní

et al. 2012

Rev. Inst. Med. trop. S. Paulo

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“…17 The mean age of the population was set at 35 years. 18 In the base case analysis, 80% of the target population (patients at risk of Chagas disease) was screened and treated. The remaining 20% followed the same disease pattern as the individuals in the no-test option, which…”

Section: Cost-effectiveness Modelmentioning

confidence: 99%

“…Assumption was made that nobody would refuse the treatment and all positive cases received treatment according to the current clinical practice in nonendemic areas. 17,18 This entails treatment with the antiparasitic drug benznidazole for 60 days, as per WHO recommendations, 21 with complete blood count and basic biochemistry monitoring at follow-up visits every 15 days. 17,18 In the no-test option, only symptomatic patients transitioning to the cardiac or gastrointestinal forms were diagnosed with Chagas disease and treated accordingly.…”

Section: Disease States and Transition Probabilitiesmentioning

confidence: 99%

“…17,18 This entails treatment with the antiparasitic drug benznidazole for 60 days, as per WHO recommendations, 21 with complete blood count and basic biochemistry monitoring at follow-up visits every 15 days. 17,18 In the no-test option, only symptomatic patients transitioning to the cardiac or gastrointestinal forms were diagnosed with Chagas disease and treated accordingly. Based on the literature, the probability of moving from the indeterminate form to the cardiac form was set at 2% a year for the no-test option (progression to cardiomyopathy in untreated patients 22 ) and at 0·5% for the test option.…”

Section: Disease States and Transition Probabilitiesmentioning

confidence: 99%

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Cost-effectiveness of Chagas disease screening in Latin American migrants at primary health-care centres in Europe: a Markov model analysis

Requena‐Méndez

Bussion

Aldasoro

et al. 2017

The Lancet Global Health

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SummaryBackground Chagas disease is currently prevalent in European countries hosting large communities from Latin America. Whether asymptomatic individuals at risk of Chagas disease living in Europe should be screened and treated accordingly is unclear. We performed an economic evaluation of systematic Chagas disease screening of the Latin American population attending primary care centres in Europe.

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“…Prevalence of gastrointestinal involvement in Chagas disease patients varies depending on the tests performed for the evaluation and the geographical area where the study is performed: gastrointestinal involvement prevalence in endemic countries ranges from 14% to 35%, although in non-endemic countries it is 5-14%. [3][4][5][6][7][8][9] Patients with chronic Chagas disease and colonic involvement show slowly progressive constipation and may manifest colonic dilatation or megacolon that can be discovered as a result of radiological examinations. The sigmoid and the rectum are dilated in nearly all cases of megacolon, whereas dilation of more proximal colonic segments is rare.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Rectocolonic Morphology and Function in Patients with Chagas Disease in Barcelona (Spain)

Salvador¹,

Mego²,

Sánchez-Montalvà³

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. The aim of this study was to determine the relationship between colonic symptoms, radiological abnormalities, and anorectal dysfunction in patients with Chagas disease. We performed a cross-sectional study of untreated patients diagnosed with Chagas disease. All patients were evaluated clinically (by a questionnaire for colonic symptoms based on Rome III criteria) and underwent a barium enema and anorectal manometry. A control group of patients with functional constipation and without Chagas disease was included in the study. Overall, 69 patients were included in the study: 42 patients were asymptomatic and 27 patients had abdominal symptoms according to Rome III criteria. Anorectal manometry showed a higher proportion of abnormalities in symptomatic patients than in asymptomatic ones (73% versus 21%, respectively; P 0.0001).

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Clinical profile of Trypanosoma cruzi infection in a non-endemic setting: Immigration and Chagas disease in Barcelona (Spain)

Cited by 100 publications

References 17 publications

Scientific authorships and collaboration network analysis on Chagas disease: papers indexed in PubMed (1940-2009)

Scientific authorships and collaboration network analysis on Chagas disease: papers indexed in PubMed (1940-2009)

Cost-effectiveness of Chagas disease screening in Latin American migrants at primary health-care centres in Europe: a Markov model analysis

Assessment of Rectocolonic Morphology and Function in Patients with Chagas Disease in Barcelona (Spain)

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