Clinical profile of primary central nervous system demyelinating disorders: A tertiary care hospital-based study in Guwahati

Mahanta, Anirban; Manisha, Manisha; Goswami, Munindra; Das, Manas

doi:10.4103/injms.injms_10_22

Cited by 1 publication

(4 citation statements)

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“…Manisha et al . in a single-center Indian study similarly reported preponderance of NMOSD over MS. [ 4 ] This is also similar to data from other Asian counterparts, which showed a higher prevalence of NMOSD compared to the western population. [ 2 ]…”

Section: Discussionsupporting

confidence: 88%

“…Overall, the mean age of presentation in our study was 30.5 ± 11.15, which is similar to results from other Indian and western population studies. [ 4 - 6 ] Among all the groups, patients with ADEM showed a younger age of onset (22.33 ± 9.07), which might be due to the usual common occurrence of ADEM in children and younger adults compared to older adults. [ 7 ] In our study, the NMOSD group showed younger (30.90 ± 11.74) mean age of onset compared to patients with MS (32 ± 11.30).…”

Section: Discussionmentioning

confidence: 99%

“…and another multicenter cross-sectional South American study. [ 4 , 6 ] However, Indian studies by Nayak et al . and Pandit and Kundapur showed a higher age of onset in the NMOSD group compared to MS. [ 5 , 8 ] Likewise, other major hospital-based studies from Asia and worldwide prevalence studies also showed younger clinical disease onset in MS compared to NMOSD in contrast to our study.…”

Section: Discussionmentioning

confidence: 99%

“…Overall, the most common presentation was myelitis (52.3%) followed by ON (45.5%) similar to results from other studies. [ 4 , 5 ] In both males and females, the most common presentations were ON and myelitis. Many of the patients were polysymptomatic especially ON and myelitis together seen in 9 (20.5%).…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Clinical and radiological spectrum of acquired inflammatory demyelinating diseases of the central nervous system in a tertiary care center

Sivaroja,

Sowmini,

Muralidharan

et al. 2024

JNRP

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Objectives: Demyelinating diseases of central nervous system (CNS) are a broad spectrum of conditions with autoimmune process against myelin. In a resource limited country like India, it is imperative to perform proper clinical evaluation, neuroimaging to differentiate among various categories of CNS demyelinating diseases to decide regarding further workup and treatment. The objective of our study was to determine clinical presentation, imaging findings, serology results, diagnosis, and treatment outcome of primary demyelinating disorders of CNS. Materials and Methods: In this prospective study, a total of 44 patients were enrolled over a period of 1 year. After proper evaluation, patients were categorized into different groups applying newer diagnostic criteria. Patients were treated with steroids, appropriate immunomodulatory therapy, and outcomes were analyzed. Results: The majority of cases were of neuromyelitis optica spectrum disorder (NMOSD) (45.5%) with an overall female-to-male ratio of 3.4:1 and mean age of presentation was 30.5 ± 11.15. Myelitis (52.3%) followed by optic neuritis (45.5%) was the most common initial presentation. The most common site of involvement on magnetic resonance imaging was the spinal cord (particularly the cervicodorsal cord). The majority showed good response to therapy (77.27%) and two patients did not survive. Conclusion: Higher disability observed among seropositive NMOSD patients warrants aggressive treatment during the first attack itself. It is important to suspect myelin oligodendrocyte glycoprotein antibody disease in patients with preceding viral infection. A good outcome in the majority is likely due to the availability of serological assays and aggressive immunomodulatory therapy.

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Section: Discussionsupporting

confidence: 88%