Clinical profile of patients with heart failure can predict rehospitalization and quality of life

Mauro, Michele Di; Petroni, Renata; Clemente, Daniela; Foschi, Massimiliano; Tancredi, Fabrizio; Camponetti, Virginia; Gallina, Sabina; Calafiore, Antonio M.; Penco, María; Romano, Silvio

doi:10.2459/jcm.0000000000000619

Cited by 12 publications

(9 citation statements)

References 37 publications

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“…Severe TR leads to RHF in the absence of surgical management [29]. In our study, 61 patients (29.3%) experienced at least one episode of RHF requiring hospitalization during follow-up.…”

Section: Tr Outcomementioning

confidence: 59%

Characteristics and prognosis of patients with significant tricuspid regurgitation

Bohbot

Chadha

Delabre

et al. 2019

Archives of Cardiovascular Diseases

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“…Severe TR leads to RHF in the absence of surgical management [29]. In our study, 61 patients (29.3%) experienced at least one episode of RHF requiring hospitalization during follow-up.…”

Section: Tr Outcomementioning

confidence: 59%

Characteristics and prognosis of patients with significant tricuspid regurgitation

Bohbot

Chadha

Delabre

et al. 2019

Archives of Cardiovascular Diseases

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“…The pathological changes of the heart after myocardial infarction can well simulate the pathological manifestations of human myocardial infarction. 25,26 Myocardial fibrosis produces large amounts of α-SMA and collagenⅠ, which increase muscle tissue stiffness and decrease cardiac contractility, leading to fatal arrhythmia. 27 BPS is a stable prostacyclin analog, with vasodilatation, antiplatelet agglutination, anti-inflammatory, and other pharmacological effects.…”

Section: Discussionmentioning

confidence: 99%

“…Ligation of the left anterior descending coronary artery in mice is a common model for studying postinfarcted ventricular remodeling and heart failure. The pathological changes of the heart after myocardial infarction can well simulate the pathological manifestations of human myocardial infarction 25,26 . Myocardial fibrosis produces large amounts of α‐SMA and collagenⅠ, which increase muscle tissue stiffness and decrease cardiac contractility, leading to fatal arrhythmia 27 .…”

Section: Discussionmentioning

confidence: 99%

Beraprost sodium attenuates the development of myocardial fibrosis after myocardial infarction by regulating GSK‐3β expression in rats

Li,

Wang,

Liu

et al. 2023

Immunity Inflam & Disease

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ObjectiveThe aim of this study was to elucidate the mechanism of beraprost sodium (BPS) in the intervention of myocardial fibrosis after myocardial infarction (MI) through glycogen synthase kinase‐3β (GSK‐3β) and to provide new ideas for intervention in myocardial fibrosis.Materials and MethodsMI model rats given BPS and cardiac fibroblasts (CFs) treated with BPS and TGF‐β. HE staining and Masson staining were used to detect the pathological changes of myocardial tissue. Fibrotic markers were detected by immunohistochemical staining. The expressions of GSK‐3β, cAMP response element binding protein (CREB), and p‐CREB were analyzed by qPCR and western blot analysis. EDU staining was used to detect the proliferation of CFs. The promoter activity of GSK‐3β was detected by luciferase assay. Chromatin immunoprecipitation assay was used to detect the binding levels of GSK‐3β promoter and Y‐box binding protein 1 (YBX1). The levels of intracellular cyclic adenosine monophosphate (cAMP) were analyzed by enzyme‐linked immunosorbent assay (ELISA).ResultsAfter operation, BPS improved myocardial fibrosis and upregulated GSK‐3β protein expression in male SD rats. BPS can down‐regulate α‐smooth muscle actin (α‐SMA) level and up‐regulate GSK‐3β protein expression in CFs after TGF‐β stimulation. Furthermore, GSK‐3β knockdown can reverse the effect of BPS on TGF‐β‐activated CFs, enhance α‐SMA expression, and promote the proliferation of CFs. BPS could regulate GSK‐3β expression by promoting the binding of GSK‐3β promoter to YBX1. BPS induced upregulation of p‐CREB and cAMP, resulting in reduced fibrosis, which was reversed by the knockdown of GSK‐3β or prostaglandin receptor (IPR) antagonists.ConclusionBPS treatment increased the binding of YBX1 to the GSK‐3β promoter, and GSK‐3β protein expression was upregulated, which further caused the upregulation of p‐CREB and cAMP, and finally inhibited myocardial fibrosis.

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“…Impaired quality of life is affected by various factors, including severity and duration of the disease, level of patient care, patient's environment, and other contributing factors. Therefore, all psychological and physical dimensions of the disease affecting the individual need to be measured (4,5). According to H Cardiovasc Biomed J 2022; 2(1): [11][12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Health related quality of life in patients with chronic heart failure

Soltani¹,

Baghbeheshti²,

Ghorbani³

et al. 2022

CBJ

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Objectives: Heart failure is one of the most common chronic cardiovascular diseases, which often triggers disability or death. Health-related Quality of life (HRQoL) is one of the most critical factors in deciding how to treat these patients. In this study, we want to figure out the effect of different factors on the quality of life in patients. Methods: This cross-sectional study was performed on 129 patients with heart failure referring to the center of Afshar Hospital in Yazd City, Iran 2017-2018. The standard (Shot Form survey) SF-36 questionnaire was used to measure different dimensions of quality of life. Results: In the present study, 77 men and 52 women with heart failure were included and the relationship between comorbidities, heart failure classification factors, age, sex, and history of hospitalization with quality of life was measured. The result revealed a significantly higher quality of life in patients under 50 years (P = 0.005) as well as in men (p<0.001). And in the total population, the average quality of life appeared to be 45.46. Conclusions: Quality of life in patients with heart failure is related to gender and age, so in women over 50 years, the quality of life proved lower but not related to factors such as, hospitalization, type of failure and stage of the disease. Among diseases related to heart failure, only people with high blood pressure showed lower quality of life scores. The total quality of life index score among our subjects was reported to be moderate to low.

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Clinical profile of patients with heart failure can predict rehospitalization and quality of life

Abstract: Clinical, laboratory and echocardiographic profile is crucial to predict long-term QOL of patients admitted for heart failure.

Cited by 12 publications

References 37 publications

Characteristics and prognosis of patients with significant tricuspid regurgitation

Characteristics and prognosis of patients with significant tricuspid regurgitation

Beraprost sodium attenuates the development of myocardial fibrosis after myocardial infarction by regulating GSK‐3β expression in rats

Health related quality of life in patients with chronic heart failure

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