Clinical Profile of Patients Admitted with Swine-Origin Influenza A (H1N1) Virus Infection: An Experience from A Tertiary Care Hospital

Mehta, Asmita; Kumar, Vaijayanthee; Nair, Suresh; Joseph, F; Kumar, G S Prasanna; Singh, Sanjeev K.

doi:10.7860/jcdr/2013/5657.3477

Cited by 15 publications

(22 citation statements)

References 5 publications

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“…were found to be similar with the other studies. 10,11 There was a statistically significant association between outcome of the admitted patients and co-morbid conditions. Study conducted by KS Amaravathi also identified co morbid conditions as a major decisive factors in relation to outcome of the disease.…”

Section: Resultsmentioning

confidence: 96%

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Clinico-epidemiological profile of confirmed swine flu (H1N1) cases admitted at an infectious disease hospital in Kolkata, India

Sardar

Mandal

2016

Int J Community Med Public Health

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Section: Resultsmentioning

confidence: 96%

“…Major presenting complaints were fever, cough and cold, respiratory distress, sore throat, which are also similar with the other studies. [9][10][11]13 Important co-morbidities like diabetes mellitus, hypertension, ischemic heart disease, COPD etc. were found to be similar with the other studies.…”

Section: Resultsmentioning

confidence: 99%

Clinico-epidemiological profile of confirmed swine flu (H1N1) cases admitted at an infectious disease hospital in Kolkata, India

Sardar

Mandal

2016

Int J Community Med Public Health

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“…[13][14][15][16][17][18][19][20] Myalgia and throat pain were seen in half of the patients, whereas dyspnea was present in one third which varied with few of the previous studies. 12,17,21 This suggest that respiratory symptoms are more common in swine flu along with myalgia. Most of the physical findings were also related to respiratory system.…”

Section: Discussionmentioning

confidence: 96%

“…Mean age of study population was 51.43 years (±19.4) suggesting that hospital admission due to infection was common in higher age group. [12][13][14][15][16] Fever and cough were the most common presenting symptoms seen in majority of patients as reported from USA, Japan, Mexico and India. [13][14][15][16][17][18][19][20] Myalgia and throat pain were seen in half of the patients, whereas dyspnea was present in one third which varied with few of the previous studies.…”

Section: Discussionmentioning

confidence: 99%

Clinical profile and outcome of patients admitted with swine-origin Influenza A H1N1 virus infection at a tertiary care hospital in Western India

Sharma

Mathur

2019

Int J Adv Med

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Background: Most of the studies on swine flu H1N1 have been done during the pandemic phase. There was a sudden upsurge in virus activity in 2015 at many centers in India. The present study was designed to assess the current status and pattern of H1N1 infection. The primary objective of this study is to study the clinical profile of patients admitted with Swine-origin influenza A (H1N1) virus infection and Secondary objective is to study the clinical outcome in terms of morbidity and mortality.Methods: This was a retrospective observational study done at a tertiary care centre from March 2015 to April 2016. All admitted and confirmed cases of H1N1 swine flu infection were studied for demographic details, co-existing medical conditions and clinical presentation. Data regarding the course of disease, complications, treatments and outcomes were recorded from the clinical record.Results: Common presenting symptoms were cough and fever (95%). Common findings were fever (62.5%), tachycardia, tachypnea and crepitation on auscultation (58.5%). Associated comorbidities were Diabetes mellitus (19.5%), Chronic kidney disease (17%), immunosuppression (9.8%). Consolidation was seen in nearly half of the patients on radiological imaging. Complications noted in our patients were pneumonia (45%), respiratory failure (31%) and ARDS (14.6%). Seventeen percent of patients required non-invasive and invasive mechanical ventilation. Around 25 percent of cases, required ICU admission while two patients died during the hospital stay.Conclusions: The study emphasizes and restates the morbidities caused by H1N1 swine influenza infection as nearly half of the patients in this study experienced severe illness and complications.

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“…4,5 Previous report indicated that pregnancy is associated with higher rate of complications and thus high mortality rate was found. 6,7 The risk factor with high disease mortality was found varying among different populations. Therefore, population based study is warranted in order to rule out risk factors with high disease mortality.…”

Section: Introductionmentioning

confidence: 99%

A cross sectional analysis on the clinical presentation and outcome of H1N1 influenza patients in a tertiary care hospital in Central Kerala

George

Simson

et al. 2019

Int J Adv Med

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Background: The World Health Organization raised pandemic H1N1 influenza alert level to phase 6 in June 2009 due to a widespread community transmission on two continents. The recent surge in positive H1N1 cases necessitates a revisit to the clinical profile of the 2009 pandemic. This study was aimed to analyse the clinical profile and outcome of swab positive H1N1 patients.Methods: A cross sectional analysis on the clinical presentation and primary out come in the confirmed H1N1 influenza cases was done. H1N1 confirmation was done using real time reverse transcriptase-Polymerase Chain Reaction in throat swab samples. The data were analysed statistically and presented in percentage.Results: Total 31 cases of severe H1N1 were included in the study. Majority of the cases (16/31) were between15 to 30 yrs of age. Among the total cases, 27 cases were females (87.1%) of which 11 cases were pregnant (35.5%). The predominant presenting symptoms were fever (100%), breathlessness (80.6%), body ache (45.2%), headache (29%) and sore throat (29%). Twenty three of the 31 patients (74.2%) survived while 8 succumbed to the illness (25.8%). All the patients required ICU admission and 8 underwent invasive ventilation. The mortality was high among the ventilated patients (p=0.0064).Conclusions: Pregnancy was associated with higher rate of complications. Early respiratory support did not help in preventing progression to respiratory failure in most of the patients. Vaccination, early recognition of the disease and prompt initiation of treatment appear to be the only way to reduce H1N1 disease progression and mortality.

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Clinical Profile of Patients Admitted with Swine-Origin Influenza A (H1N1) Virus Infection: An Experience from A Tertiary Care Hospital

Cited by 15 publications

References 5 publications

Clinico-epidemiological profile of confirmed swine flu (H1N1) cases admitted at an infectious disease hospital in Kolkata, India

Clinico-epidemiological profile of confirmed swine flu (H1N1) cases admitted at an infectious disease hospital in Kolkata, India

Clinical profile and outcome of patients admitted with swine-origin Influenza A H1N1 virus infection at a tertiary care hospital in Western India

A cross sectional analysis on the clinical presentation and outcome of H1N1 influenza patients in a tertiary care hospital in Central Kerala

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