Clinical Profile of Non-Motor Symptoms in Patients with Essential Tremor:
                        Impact on Quality of Life and Age-Related Differences

Shalash, Ali; Mohamed, Hadeer; Mansour, Alia H.; Elkady, Ahmed; Elrassas, Hanan; Hamid, Eman; Elbalkimy, Mahmoud

doi:10.5334/tohm.471

Cited by 10 publications

(9 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results replicate previous findings of a relatively higher prevalence and severity of anxiety and depression among patients with idiopathic dystonia or ET than in healthy controls ( 6 , 8 , 9 , 11 , 13 – 16 , 18 – 20 , 30 ). Although our study did not find a significant difference between the study groups in terms of the frequency of psychiatric disorders diagnosed according to the DSM-IV Axis I ( p = 0.11), psychiatric disorders tended to be more prevalent among patients with IFD than among healthy controls.…”

Section: Discussionsupporting

confidence: 91%

“…Indeed, recent studies have shown that such neuropsychiatric manifestations, including depression, anxiety, and obsessive-compulsive traits, are observed in patients with focal or segmental dystonia (6)(7)(8)(9)(10)(11)(12)(13)(14)(15). The recent finding that patients with essential tremor (ET), a common motor characterized dysfunction of the cerebellum and consequent isolated tremor, also present with neuropsychiatric symptoms, may implicate psychiatric manifestations as part of the primary pathophysiology of movement disorders (3,(16)(17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neuropsychiatric Symptoms and Quality of Life in Patients With Adult-Onset Idiopathic Focal Dystonia and Essential Tremor

2020

View full text Add to dashboard Cite

Background: While idiopathic focal dystonia (IFD) and essential tremor (ET) have been considered pure movement disorders, they reportedly induce neuropsychiatric manifestations and may thus be more accurately described as network disorders. Methods: The present multi-center, cross-sectional, case-control study evaluated the severity of depression and anxiety with the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI), respectively; the frequency of neuropsychiatric disorders with the Korean-Mini International Neuropsychiatry Interview; and QoL with the Short-Form 36 (SF-36). Results: Seventy-four subjects participated in this study (IFD, 27; ET, 24; controls, 23). The BDI and BAI scores were higher in the IFD and ET groups than in the control group. Although the frequency of neuropsychiatric disorders diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition Axis I was comparable among the groups, the prevalence of major depressive disorder tended to be high among patients with IFD. QoL was correlated with the severity of depression and anxiety across the groups. Conclusions: Depression and anxiety are more severe in patients with IFD and ET compared to healthy controls, while their severity is similar among patients with IFD and ET. Axis I major depressive disorder is relatively more prevalent in patients with IFD. Neuropsychiatric symptoms affect QoL regardless of the affected individual's condition, addressing neuropsychiatric symptoms in patients with movement disorders may be crucial to improving their QoL.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Neuropsychiatric Symptoms and Quality of Life in Patients With Adult-Onset Idiopathic Focal Dystonia and Essential Tremor

2020

View full text Add to dashboard Cite

show abstract

“…As expected and as noted in prior studies [45][46][47], patients with age at onset of tremor over 65 years had a significantly higher prevalence of cognitive impairment (37.0% vs 13.1%, p = 0.003). Several studies have shown cognitive deficits in ET patients exceeding those of age-matched [3,48,49] and historical controls [50]. A Spanish study found a higher incidence of dementia in ET patients versus controls (7.8% vs 3.9%, unadjusted relative risk = 2.08, p = 0.006) over a mean follow-up of 3.2 years, and ET patients over 65 were twice as likely to develop dementia compared to controls [46].…”

Section: Adj P (Et Plus Vs Et-pd) Medication Historymentioning

confidence: 99%

Phenotypic Features of Isolated Essential Tremor, Essential Tremor Plus, and Essential Tremor-Parkinson’s Disease in a Movement Disorders Clinic

Bellows

Jankovic

2021

Tremor and Other Hyperkinetic Movements

View full text Add to dashboard Cite

Background: Patients with essential tremor were initially considered to have isolated tremor, but additional motor and non-motor features have been increasingly recognized. The term "essential tremor plus" was adopted by the Task Force on Tremor of the International Parkinson and Movement Disorder Society to describe essential tremor patients with additional neurologic signs.Objectives: To characterize essential tremor patients and their phenotypes in a movement disorders clinic population in the context of the new tremor classification.Methods: Demographic, clinical, historical, treatment, and diagnostic data were retrospectively collected on 300 patients diagnosed by movement disorder experts with essential tremor. Patients were classified as having essential tremor, essential tremor plus, or essential tremor-Parkinson's disease combination, and features between these groups were compared. Results:Of the 300 patients, 20.7% were classified as isolated essential tremor, 53.3% as essential tremor plus, and 26.0% as essential tremor-Parkinson's disease. There was no significant difference in the duration of tremor symptoms. Essential tremor plus patients were more likely to have dystonia, tandem gait abnormalities, head tremor and greater tremor severity. Essential tremor-Parkinson's disease patients were more likely to have RBD symptoms. There was no significant difference in cognitive impairment between essential tremor plus and essential tremor-Parkinson's disease patients.Conclusions: Additional motor and non-motor features, including parkinsonism, are common in patients with essential tremor. Further studies are needed to clarify essential tremor phenotypes and to provide insights into possible subtypes.Highlights: 300 patients with essential tremor from a movement disorders clinic were re-classified based on the Movement Disorder Society Consensus Statement on the Classification of Tremors. Additional motor and non-motor features, including parkinsonism, were common, and only 20.7% of patients remained classified as isolated essential tremor.

show abstract

“…В силу того, что ЭТ чаще всего дебютирует у пациентов пожилого возраста, специалисты считали, что когнитивные нарушения -это не что иное, как характерное для людей в этом возрасте. Однако, в работе Shalash A. et al, где пациенты были разделены на 2 группы: младше 45 лет и старше 45 лет, было выявлено, что при оценке когнитивных нарушений в группе «младше 45 лет» они были выражены значительнее, чем во второй группе, что опровергает теорию корреляции нарушений мыслительных способностей у пациентов с возрастом [17].…”

Section: результаты и обсуждениеunclassified

“…Обоняние и слух. Нарушение слуха у пациентов с ЭТ связывают в некоторых источниках с возможной патологией улитки, а где-то с таким белком, как коннексин, который участвует в ряде патологических состояний у человека, в частности при потере слуха и нейродегенеративных расстройствах [17,18]. При обследовании в домах престарелых 250 пациентов с ЭТ, 127 с БП и 127 здоровых людей было выявлено, что слуховой аппарат был у большинства пациентов с ЭТ, а при выборке из них 74 пациентов при проведении аудиометрии чистым тоном выявлены аномальные значения на высоких частотах, что говорит в пользу наличия у таких пациентов высокочастотной нейросенсорной тугоухости [19].…”

Section: результаты и обсуждениеunclassified

Essential tremor not just a tremor (review)

Shiderova¹,

Karimova²,

Kaishibayeva³

et al. 2021

Medicine

View full text Add to dashboard Cite

Essential tremor is one of the most common movement disorders. The nature of this disease is not fully understood. It was believed that this pathology manifests itself only by tremor, and symptoms such as depression, anxiety and apathy in patients with essential tremor can only be regarded as a reaction to the presence of tremor. Cognitive impairment is a concomitant pathology that can occur in the elderly, which accounts for a more frequent onset of the disease. But is it really so Purpose of the study. To study the literature data to identify the presence in patients with essential tremor of such signs that can be attributed to the group of "non-motor" symptoms. Material and methods. In order to study the literature data, a search was carried out in the Web of Science, PubMed databases. During the search, all articles published since 2000 were examined and the following terms were used in combination with "essential tremor": "non-motor symptoms", "anxiety", "depression", "apathy", "cognitive impairment", "sleep disorders", "hearing impairment", "hyposmia". The main search terms were studies based on the study of patients with essential tremor: meta-analyzes, original studies, retrospective and cohort studies. Results and discussion. It can be unambiguously argued that symptoms such as anxiety, depression, apathy and cognitive, hearing and smell dysfunctions are characterised to the patients with essential tremor. The first three manifestations were attributed to the response to the presence of tremor. And cognitive functions, hearing and smell dysfunctions was considered a concomitant pathology, which occurs quite often in old age, which accounts for a more frequent onset of the disease. But in reality, everything is not so simple. The literature data, which began to appear over the past 20 years, make it clear that the previously mentioned clinical manifestations may well be regarded as "non-motor" symptoms of essential tremor. Conclusion. Nowadays neurologists are increasingly faced with the problem of differential diagnosis of essential tremor. Despite the fact that everything was very simple and clear on the diagnosis of this disease, in recent years more and more data have appeared in favor of the fact that essential tremor is a heterogeneous disease that manifests not only by tremor. But this is also a disease, which, due to its heterogeneity of pathophysiology, can give great variability in the clinical picture. Keywords: essential tremor, nonmotor symptoms, anxiety, depression, cognitive impairnment, dementia.

show abstract

Clinical Profile of Non-Motor Symptoms in Patients with Essential Tremor: Impact on Quality of Life and Age-Related Differences

Cited by 10 publications

References 33 publications

Neuropsychiatric Symptoms and Quality of Life in Patients With Adult-Onset Idiopathic Focal Dystonia and Essential Tremor

Neuropsychiatric Symptoms and Quality of Life in Patients With Adult-Onset Idiopathic Focal Dystonia and Essential Tremor

Phenotypic Features of Isolated Essential Tremor, Essential Tremor Plus, and Essential Tremor-Parkinson’s Disease in a Movement Disorders Clinic

Essential tremor not just a tremor (review)

Contact Info

Product

Resources

About