BACKGROUND Lung cancer is presently the most common malignant disease and is the leading cause of cancer deaths in the world. An increase in incidence of lung cancer has been observed in India. The relative frequency and clinicopathological profile of different histological subtypes of lung cancer have shown marked regional and geographical variation. The aim of this study was to evaluate the clinicopathological profile of lung cancer in patients of Tripura, India. MATERIALS AND METHODS This prospective study was conducted over a period of 4 years, in patients with clinically and radiologically suspected lung cancer, who attended our hospital from March, 2012 to February, 2016. RESULTS Out of 295 patients, 239 were male, 56 were female; 69.49% of patients were between 51 to 70 years, and 85.42% patients were smokers. The most common presenting symptom was cough (74.24%) followed by chest pain (66.78%). Mass lesion (43.39%) was the most common radiological presentation followed by pleural effusion (26.44%). The commonest mode of diagnosis was imageguided FNAC; confirmed diagnosis in 54.58% patients. The most common histopathological type was squamous cell carcinoma (40.00%) followed by adenocarcinoma (34.58%). Almost 75% patients were diagnosed at advanced stage of disease. CONCLUSION It was found that lung cancer, a disease of elderly people, predominantly affects the male with smoking still remains a major risk factor. CT-guided FNAC is an important diagnostic tool. Squamous cell carcinoma was the most common histopathological type. Majority of the patients were unaware about the ill effects of smoking.