Clinical profile of insulinoma: analysis from a tertiary care referral center in India

Gopal, Raju A.; Acharya, Shrikrishna V.; Menon, Sunil K.; Bandgar, Tushar; Menon, P. S. N.; Shah, Nalini

doi:10.1007/s12664-010-0051-y

Cited by 4 publications

(1 citation statement)

References 24 publications

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“…A review of the relevant studies published from India was also compared and contrasted with the current study and the findings are summarized in Table 4 . [ 25 29 30 31 32 ] We found a male preponderance in our series which was like a prior report from India, contrasting with many Western series with female preponderance. Further, while the calculated sensitivity of CT scan was similar to our study, MRI in this series demonstrated better sensitivity than our study (85.7% vs 64.3%).…”

Section: Discussionsupporting

confidence: 81%

Diagnostic Modalities, Management Considerations, and Outcomes of Insulinoma: A Case Series from a Tertiary Care Centre

Shetty,

Das,

Jayant

et al. 2024

Indian Journal of Endocrinology and Metabolism

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Introduction: Insulinomas are rare, usually sporadic, and typically benign pancreatic neuroendocrine tumours. Pre-operative localization is challenging and evidence on comparative analysis of anatomic and scintigraphic modalities for pre-operative tumour localization is limited, even in contemporary series. Methods: The current study was designed to study the clinical features and management challenges of insulinomas managed at a tertiary care centre. Clinical features, diagnosis, imaging techniques, surgical procedures, and outcomes details were collated. Pre-operative imaging techniques (CT/MRI, nuclear scintigraphy) were compared with intraoperative and histopathological findings to assess their accuracy of localization. Results: Thirty-seven patients (15 females [42%]; median age 36 years [IQR 28–49]) were included in the study. In four patients (10.8%), the tumour occurred in the setting of multiple endocrine neoplasia type 1 (MEN 1) while the remaining were sporadic. The sensitivity of pre-operative localization was 61.5% (multiphasic CT), 66.6% (multiphasic MRI), 100% (68Ga Exendin-4 PET-CT), and 91.6% (EUS). Three patients with normal multiphasic CT had localization on 68Ga Exendin-4 PET-CT. The positive predictive value (PPV) of both Exendin-PET-CT and EUS was similar at 91.6% and 91.6%, respectively. All patients (except one with nesidioblastosis), who underwent enucleation or partial pancreatic resection, were cured. Conclusion: 68Ga Exendin-4 PET-CT based is a non-invasive imaging modality that has high sensitivity and PPV and can be used as a first-line imaging modality. The overall prognosis of these tumours is good with high cure rates attained following surgical resection.

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Section: Discussionsupporting

confidence: 81%

Diagnostic Modalities, Management Considerations, and Outcomes of Insulinoma: A Case Series from a Tertiary Care Centre

Shetty,

Das,

Jayant

et al. 2024

Indian Journal of Endocrinology and Metabolism

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Insulinoma—Accurate Preoperative Localization Is the Key to Management: An Initial Experience

Sharma

Varshney

Kasliwal

et al. 2022

Indian J Surg Oncol

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Dual energy spectral CT imaging of insulinoma—Value in preoperative diagnosis compared with conventional multi-detector CT

Xiang

Tao

et al. 2012

European Journal of Radiology

119

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Clinical profile of insulinoma: analysis from a tertiary care referral center in India

Abstract: This audit shows that all patients with insulinoma develop hypoglycemia within 48 h of fasting. CT of pancreas localizes the lesion in two thirds of cases and would be a useful initial investigation in patients with suspected insulinoma.

Cited by 4 publications

References 24 publications

Diagnostic Modalities, Management Considerations, and Outcomes of Insulinoma: A Case Series from a Tertiary Care Centre

Diagnostic Modalities, Management Considerations, and Outcomes of Insulinoma: A Case Series from a Tertiary Care Centre

Insulinoma—Accurate Preoperative Localization Is the Key to Management: An Initial Experience

Dual energy spectral CT imaging of insulinoma—Value in preoperative diagnosis compared with conventional multi-detector CT

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