Clinical profile of children with moderate-to-severe eosinophilia presenting to a tertiary hospital in Nepal

Shrestha, Shrijana; Timila, Dipsal; Karki, Utkarsh; Shrestha, Ashis; Bhandary, Shital

doi:10.1258/td.2012.120284

Cited by 2 publications

(7 citation statements)

References 8 publications

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“…However, as identification was based on visual identification only, confirmation is not certain. Three out of 84 children with eosinophilia presenting at a university hospital in Kavre were serologically positive for fasciolosis [66], while in another case series on eosinophilia in children, paragonimosis was suggested as a possible cause, given that a significant proportion of patients had the habit of eating undercooked fresh water crab meat [80]. In India, human cases of Fasciolopsis buski have been described from the Nepal bordering states of Bihar [81], [82] and Uttar Pradesh [83].…”

Section: Resultsmentioning

confidence: 99%

The Burden of Parasitic Zoonoses in Nepal: A Systematic Review

et al. 2014

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BackgroundParasitic zoonoses (PZs) pose a significant but often neglected threat to public health, especially in developing countries. In order to obtain a better understanding of their health impact, summary measures of population health may be calculated, such as the Disability-Adjusted Life Year (DALY). However, the data required to calculate such measures are often not readily available for these diseases, which may lead to a vicious circle of under-recognition and under-funding.MethodologyWe examined the burden of PZs in Nepal through a systematic review of online and offline data sources. PZs were classified qualitatively according to endemicity, and where possible a quantitative burden assessment was conducted in terms of the annual number of incident cases, deaths and DALYs.Principal FindingsBetween 2000 and 2012, the highest annual burden was imposed by neurocysticercosis and congenital toxoplasmosis (14,268 DALYs [95% Credibility Interval (CrI): 5450–27,694] and 9255 DALYs [95% CrI: 6135–13,292], respectively), followed by cystic echinococcosis (251 DALYs [95% CrI: 105–458]). Nepal is probably endemic for trichinellosis, toxocarosis, diphyllobothriosis, foodborne trematodosis, taeniosis, and zoonotic intestinal helminthic and protozoal infections, but insufficient data were available to quantify their health impact. Sporadic cases of alveolar echinococcosis, angiostrongylosis, capillariosis, dirofilariosis, gnathostomosis, sparganosis and cutaneous leishmaniosis may occur.Conclusions/SignificanceIn settings with limited surveillance capacity, it is possible to quantify the health impact of PZs and other neglected diseases, thereby interrupting the vicious circle of neglect. In Nepal, we found that several PZs are endemic and are imposing a significant burden to public health, higher than that of malaria, and comparable to that of HIV/AIDS. However, several critical data gaps remain. Enhanced surveillance for the endemic PZs identified in this study would enable additional burden estimates, and a more complete picture of the impact of these diseases.

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Section: Resultsmentioning

confidence: 99%

The Burden of Parasitic Zoonoses in Nepal: A Systematic Review

et al. 2014

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“…Specifically, prevalence rates of Strongyloides spp. ranged from 10.8% to 46.8%, 2,5,22,23,26,29 and Schistosoma spp. was identified in 14%–28.9% of cases 5,18,22,23 .…”

Section: Resultsmentioning

confidence: 99%

“…ranged from 10.8% to 46.8%, 2,5,22,23,26,29 and Schistosoma spp. was identified in 14%-28.9% of cases.…”

Section: Aetiology Of Eosinophiliamentioning

confidence: 99%

“…5,18,22,23 A broad variation was observed in the prevalence of Toxocara canis, ranging from 7.1% to 100%. 2,5,9,19,26,27,29 The simultaneous presence of at least two parasites occurred in 18.6%-44.6% of the children with parasitosis. 2,17,22,23 The correlation between AEC and the number of detected helminths was statistically significant (p = 0.003), although not strong (ρ = 0.33).…”

Section: Aetiology Of Eosinophiliamentioning

confidence: 99%

“…Furthermore, most serological tests become positive after 4-12 weeks from the infection. 29,31,32 Consequently, due to the high prevalence of parasitosis, an antiparasitic trial treatment could be administered to children from low-income countries with eosinophilia, despite negative parasitological tests. The trial antiparasitic treatment should be based on the therapeutic protocol proposed by the Italian Society of Tropical Medicine and Global Health (Figure 5).…”

Section: Proposed Diagnostic Algorithm In Children With Eosinophiliamentioning

confidence: 99%

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From evidence to practice: A systematic review‐based diagnostic algorithm for paediatric eosinophilia across socioeconomic context

Pellegrino,

Tosca,

Timitilli

et al. 2024

Acta Paediatrica

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AimPaediatric eosinophilia is a common clinical dilemma, often leading to resource‐ and time‐consuming assessments. We aim to evaluate the main aetiologies of eosinophilia in children from different socioeconomic settings and propose a diagnostic algorithm.MethodsA systematic literature review was conducted through PubMed, Embase and the Cochrane Library. Studies published from January 2012 to June 2023 reporting the incidence and aetiology of peripheral eosinophilia in children were included. Evidence from studies on children originating from low‐ or high‐income countries was compared.ResultsA total of 15 observational studies, encompassing 3409 children, were included. The causes of eosinophilia varied based on the children's origin and the eosinophilia severity. In children from high‐income countries, allergic diseases were the leading cause, with a prevalence of 7.7%–78.2%, while parasitosis ranged from 1.0% to 9.1%. In children from low‐income countries, parasitosis was predominant, ranging from 17.7% to 88.3%, although allergic diseases were found in 2.5%–4.8% of cases. Concerning severity, allergic diseases were the leading cause of mild‐to‐moderate eosinophilia; parasitosis was associated with moderate‐to‐severe eosinophilia, while immunological disorders were mostly found in severe cases.ConclusionWe developed a step‐up diagnostic algorithm that considers the child's origin and eosinophilia severity and could optimise resource allocation.

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Clinical profile of children with moderate-to-severe eosinophilia presenting to a tertiary hospital in Nepal

Cited by 2 publications

References 8 publications

The Burden of Parasitic Zoonoses in Nepal: A Systematic Review

The Burden of Parasitic Zoonoses in Nepal: A Systematic Review

From evidence to practice: A systematic review‐based diagnostic algorithm for paediatric eosinophilia across socioeconomic context

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