Objectives:The aim of this study was to assess whether ultrasound-guided (US-guided) percutaneous drainage of breast abscesses could be used as an alternative to surgery. Methods: We performed a retrospective study. Twenty patients were included in the study who were diagnosed as having a non-specific breast abscess. Eleven patients underwent surgery whereas nine patients were treated with US-guided drainage. Ultrasonographic findings, results of treatment and follow-up were evaluated between the two groups. Results: In the US-guided drainage group, 5 patients were treated with needle aspiration and 4 were treated with catheter drainage. All cases within the needle aspiration group totally recovered. However, one case within the catheter drainage group failed. The total success rate of US-guided drainage was 88.8%. The median followup period was 21.0 days in the US-guided drainage group and 45.0 days in the surgical drainage group. There were no statistically significant differences in terms of recovery (p = 0.450) and follow-up periods (p = 0.112) between the surgical drainage and US-guided drainage groups. Conclusions: US-guided percutaneous drainage may be preferred as a first method of choice in treatment of a breast abscess. The most appropriate approach to breast abscess treatment will be possible with a multidisciplinary approach of surgery and radiology.The European Research Journal 2019;5(5):809-815 reast abscesses often develop as a complication of infectious mastitis in young women [1]. Traditional treatment includes surgical drainage and systemic administration of antibiotics. Surgery, which usually requires general anesthesia, leads to scar tissue, also requires the cessation of breast-feeding during treatment and is more expensive. However, ultrasound-guided (US-guided) percutaneous drainage is a feasible, safe, well-tolerated and successful method [2][3][4].In our study, we aimed to show that US-guided drainage of breast abscesses may be an alternative to surgical incision and drainage.