Clinical profile, aetiology, short-term outcome and predictors of poor outcome of neonatal seizures among out-born neonates admitted to a neonatal unit in Paediatric emergency of a tertiary care hospital in North India: A prospective observational study

Abstract

Neonatal seizures are common manifestations of several neurological or systemic disorders and associated with high morbidity, mortality and poor short- and long-term developmental outcomes. It is important to determine the aetiology and factors that determine the poor outcome, more so in a newly developed setting. The early detection of predictors of poor outcome will help in planning acute management, counselling, follow-up and rehabilitation services. In this prospective observational study, we looked at the clinical profile, aetiology, short-term outcomes and predictors of poor outcome of neonatal seizures among out-born neonates. The common causes were hypoxic ischaemic encephalopathy, sepsis and metabolic disturbances. One-third of neonates had poor outcome. Abnormal neurological and cardiorespiratory examination at admission; low oxygen saturation, glucose and pH; and hypoxic ischemic encephalopathy-III were predictors of poor outcome.

Retracted Article: Neonatal Hypoglycemia: Oral Dextrose Gel and Tahneek Practice

“…3 Hypoglycemia is the second most common cause of seizures in neonates. 4 However, most episodes of hypoglycemia are asymptomatic, and symptoms, when they occur, are nonspecific. 2 There is some evidence that even transient and clinically undetected episodes of NH are associated with adverse sequela, suggesting that prophylaxis should also be considered.…”