Clinical presentation, treatment, and outcome of alveolar soft part sarcoma in children, adolescents, and young adults

Kayton, Mark L.; Meyers, Paul A.; Wexler, Leonard H.; Gerald, William L.; LaQuaglia, Michael P.

doi:10.1016/j.jpedsurg.2005.10.023

Cited by 117 publications

(104 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, synovial sarcoma, rhabdomyosarcoma and epithelioid sarcoma are known for their increased incidence of lymphatic spread [31,32]. Alveolar softpart sarcoma has a predilection for the brain [33][34][35]. It has "…10% of patients have metastatic disease at diagnosis, while a further 25% of patients with localized disease subsequently develop distant spread.…”

Section: Patterns Of Metastatic Spreadmentioning

confidence: 99%

Prognostic factors in soft-tissue sarcomas: what have we learnt?

Choong¹,

Rüdiger

2008

Expert Review of Anticancer Therapy

View full text Add to dashboard Cite

Section: Patterns Of Metastatic Spreadmentioning

confidence: 99%

Prognostic factors in soft-tissue sarcomas: what have we learnt?

Choong¹,

Rüdiger

2008

Expert Review of Anticancer Therapy

View full text Add to dashboard Cite

“…It has a strong predilection for adolescents and young women from the age of 15 to 35 (Kanhere et al, 2005;Kayton et al, 2006;Wang et al, 2015). Approximately 12-27% of ASPS involve the head and neck region, 41% of these involving the orbit (Kanhere et al, 2005;Wang et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…The most common sites of metastasis are lung (42%), bones (19%), and brain (15%) (Kashyap et al, 2004;Kanhere et al, 2005). Poor prognostic factors include: increasing age, tumors larger than 5 cm and metastatic disease at initial presentation (Morris et al, 2005;Kayton et al, 2006). Due to the rare occurrence of these tumors, the optimal management remains controversial (Kim et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…It is a rare and histologically distinct soft tissue malignancy of uncertain histogenesis (Kanhere et al, 2005;Wang et al, 2015). The tumor received its name due to its pseudo-alveolar histological appearance (Kayton et al, 2006). It accounts for approximately 0.5% -1% of all soft tissue sarcomas (Alkatan et al, 2010;Kim et al, 2013;Wang et al,2015;Jour et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Alveolar soft part sarcoma of the orbit, a case report of a rare tumor

et al. 2017

View full text Add to dashboard Cite

Background: Alveolar Soft Part Sarcoma is a rare malignant tumor of uncertain histogenesis, representing 0.5-1% of all soft tissue tumors. It occurs predominantly in head and neck regions, especially the orbit and the tongue, in infants, causing no specific symptoms for an extended period of time. Case: A four year old girl was brought to consultation because of persistent swelling of her left upper and lower eyelid for the past six months. A 4 mm proptosis was noted on her left eye with significant upwards displacement of the globe. A firm, not pulsating and non tender mass was palpated, and motility examination revealed deficient abduction and infraduction. Visual acuity was 20/40 and 1/200 in the right and left eye, respectively. The computed tomography revealed an extraconal mass on the inferotemporal aspect of the left orbit, with no bony erosion or globe invasion. An excisional biopsy was made, finding a tumor with nests of clusters of large polygonal cells, separated by fibrous septa and a sinusoidal vascular channel. An Alveolar Soft Part Sarcoma was diagnosed. Our patient had a favorable post-operative follow up, and oncologic evaluations have not shown metastasis or local recurrences. Observations and Conclusions: Alveolar Soft Part Sarcoma is a rare malignant tumor of indolent course, but with propensity to distant metastases, making early diagnose and long term follow up necessary.

show abstract

“…It is poorly responsive to chemotherapy. 27,28 It harbors a characteristic t(X;17)(p11.2;q25) translocation resulting in MET activation, and histologically it has a prominent capillary vascular pattern. 29 Responses have been seen with both sunitinib 30 and cediranib, 31 small molecule tyrosine kinase inhibitors that exert antivascular effects.…”

Section: Antiangiogenesismentioning

confidence: 99%

Targeted therapy in pediatric and adolescent oncology

Bernstein

2011

Cancer

View full text Add to dashboard Cite

Cancers in children and adolescents are fortunately infrequent. Overall, cure rates are good, approximately 80%, although this varies by histology and stage. Targeted therapies aim to improve efficacy and decrease toxicity by more specifically affecting malignant cells or their supporting stroma. Cancers of early life are often of different histology than those seen in adults. Sometimes, the same pathway is affected, even if the histology is different. Toxicities may also be different, particularly in younger children. These factors render drug development in young people challenging. This article reviews some successes and challenges to that development, including brief discussions of imatinib, lestaurtinib, antiangiogenesis, and anti-GD2 therapies. Cancer 2011;117(10 suppl):2268-

show abstract

Clinical presentation, treatment, and outcome of alveolar soft part sarcoma in children, adolescents, and young adults

Cited by 117 publications

References 17 publications

Prognostic factors in soft-tissue sarcomas: what have we learnt?

Prognostic factors in soft-tissue sarcomas: what have we learnt?

Alveolar soft part sarcoma of the orbit, a case report of a rare tumor

Targeted therapy in pediatric and adolescent oncology

Contact Info

Product

Resources

About