Clinical presentation, outcomes and factors associated with mortality: A prospective study from three COVID-19 referral care centres in West Africa

Jaspard, Marie; Sow, Mamadou; Juchet, Sylvain; Diendéré, Eric Arnaud; Serra, Bernardo; Kojan, Richard; Sivahera, Billy; Martin, Christine; Kinda, Moumouni; Lang, Hans-Joerg; Sako, F.B.; Traore, Fodé Amara; Koumbem, Eudoxie; Tinto, Halidou; Sanou, Adama; Sondo, Apoline; Kaboré, Flavien; Donamou, Joseph; Guilavogui, Jean-Paul-Yassa; Velardo, Fanny; Bicaba, Brice; Marcy, Olivier; Augier, Augustin; Sani, Sayadi; Poda, Armel; Keïta, Sakoba; Anglaret, Xavier; Malvy, Denis

doi:10.1016/j.ijid.2021.05.024

Cited by 16 publications

(34 citation statements)

References 25 publications

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“…For example, on the site of Johns Hopkins University dedicated to COVID-19 [ 1 ], data clearly shows this influence on the case fatality rate corresponding to the cumulative deaths recorded 5 months after the beginning of the outbreak (12 May 2020) vs. the median age of many countries in 2017 ( Figure 1 ). This first observation has been confirmed by many studies in different countries [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ] such as in France ( Figure 2 ), and we will confirm in this paper that the age of the patients suffering from COVID-19 is a good predictor of severity.…”

Section: Introductionsupporting

confidence: 85%

Age Dependent Epidemic Modeling of COVID-19 Outbreak in Kuwait, France, and Cameroon

et al. 2022

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Revisiting the classical model by Ross and Kermack-McKendrick, the Susceptible–Infectious–Recovered (SIR) model used to formalize the COVID-19 epidemic, requires improvements which will be the subject of this article. The heterogeneity in the age of the populations concerned leads to considering models in age groups with specific susceptibilities, which makes the prediction problem more difficult. Basically, there are three age groups of interest which are, respectively, 0–19 years, 20–64 years, and >64 years, but in this article, we only consider two (20–64 years and >64 years) age groups because the group 0–19 years is widely seen as being less infected by the virus since this age group had a low infection rate throughout the pandemic era of this study, especially the countries under consideration. In this article, we proposed a new mathematical age-dependent (Susceptible–Infectious–Goneanewsusceptible–Recovered (SIGR)) model for the COVID-19 outbreak and performed some mathematical analyses by showing the positivity, boundedness, stability, existence, and uniqueness of the solution. We performed numerical simulations of the model with parameters from Kuwait, France, and Cameroon. We discuss the role of these different parameters used in the model; namely, vaccination on the epidemic dynamics. We open a new perspective of improving an age-dependent model and its application to observed data and parameters.

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Section: Introductionsupporting

confidence: 85%

Age Dependent Epidemic Modeling of COVID-19 Outbreak in Kuwait, France, and Cameroon

et al. 2022

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Section: Resultsmentioning

confidence: 99%

“…10 Lastly, the study pooling data from Burkina Faso and Guinea found hypertension was associated with death from COVID-19 infection (aOR, 2.1 [95% CI, 1.2–3.4]). 11…”

Section: Resultsmentioning

confidence: 99%

“…Four studies found preexisting CVD was associated with higher COVID-19 mortality, including 2 high-quality studies using databases from South Africa to pool together large samples. 10,11,31,32 In a national hospital registry across South Africa with 219 265 COVID-19 patients, 39% had hypertension and 23% died. 32 Both hypertension and CVD were associated with a higher adjusted odds of COVID-19 mortality (hypertension: aOR, 1.1 [95% CI, 1.0-1.1]; CVD: aOR, 2.2 [95% CI, 2.1-2.3]) after adjusting for age, race, diabetes, chronic cardiac disease, chronic renal disease, malignancy, tuberculosis, HIV, admission month, health sector, and province.…”

Section: Covid-19 Mortalitymentioning

confidence: 99%

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Emerging Viral Infections, Hypertension, and Cardiovascular Disease in Sub-Saharan Africa: A Narrative Review

et al. 2022

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Background: Sub-Saharan Africa (SSA) has the highest age-adjusted burden of hypertension and cardiovascular disease (CVD). SSA also experiences many viral infections due to unique environmental and societal factors. The purpose of this narrative review is to examine evidence around how hypertension, CVD, and emerging viral infections interact in SSA. Methods: In September 2021, we conducted a search in MEDLINE, Embase, and Scopus, limited to English language studies published since 1990, and found a total of 1169 articles. Forty-seven original studies were included, with 32 on COVID-19 and 15 on other emerging viruses. Results: Seven articles, including those with the largest sample size and most robust study design, found an association between preexisting hypertension or CVD and COVID-19 severity or death. Ten smaller studies found no association, and 17 did not calculate statistics to compare groups. Two studies assessed the impact of COVID-19 on incident CVD, with one finding an increase in stroke admissions. For other emerging viruses, 3 studies did not find an association between preexisting hypertension or CVD on West Nile and Lassa fever mortality. Twelve studies examined other emerging viral infections and incident CVD, with 4 finding no association and 8 not calculating statistics. Conclusions: Growing evidence from COVID-19 suggests viruses, hypertension, and CVD interact on multiple levels in SSA, but research gaps remain especially for other emerging viral infections. SSA can and must play a leading role in the study and control of emerging viral infections, with expansion of research and public health infrastructure to address these interactions.

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“…Several observational studies on predictors of mortality in COVID-19 patients have been undertaken in Africa, with mixed results regarding the role of diabetes as a comorbidity in death. Diabetes has been demonstrated to be a predictor of mortality in some studies [12][13][14], although this idea has not been supported in others [15][16][17][18]. Varied study designs and populations provide different estimates and impact sizes in these published publications.…”

Section: Introductionmentioning

confidence: 98%

Diabetes Mellitus is Associated With Higher COVID-19 Mortality Rates in Sub-Saharan Africa: A Systematic Review and Meta-analysis

Bepouka¹,

Odio²,

Mangala³

et al. 2022

Cureus

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The rate of COVID-19-related mortality among patients with diabetes mellitus in Sub-Saharan Africa (SSA) is unknown. The current study aimed to determine the mortality rate of COVID-19 among diabetes patients in SSA. We performed a systematic review of research articles until July 1, 2021. A literature review was conducted in accordance with the PRISMA guidelines to gather relevant data. A random effects model was used to calculate odds ratios and 95% confidence intervals (CIs). We used Egger's tests and Begg's funnel plot to examine publication bias. The mortality rate of 7778 COVID-19 patients was analyzed using data from seven studies. The I 2 test was used to determine the heterogeneity between studies. The meta-analysis revealed that diabetes mellitus was linked to a 1.39-fold increase in the risk of death among COVID-19 inpatients (95% CI: 1.02-1.76). According to our findings, there was no significant heterogeneity between studies, and there was no publication bias. The present review describes an association between diabetes mellitus and the risk of COVID-19 mortality in SSA.

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Clinical presentation, outcomes and factors associated with mortality: A prospective study from three COVID-19 referral care centres in West Africa

Cited by 16 publications

References 25 publications

Age Dependent Epidemic Modeling of COVID-19 Outbreak in Kuwait, France, and Cameroon

Age Dependent Epidemic Modeling of COVID-19 Outbreak in Kuwait, France, and Cameroon

Emerging Viral Infections, Hypertension, and Cardiovascular Disease in Sub-Saharan Africa: A Narrative Review

Diabetes Mellitus is Associated With Higher COVID-19 Mortality Rates in Sub-Saharan Africa: A Systematic Review and Meta-analysis

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