Clinical presentation of patients with dacryolithiasis

Andreou, P.; Rose, Geoffrey E.

doi:10.1016/s0161-6420(02)01107-7

Cited by 18 publications

(15 citation statements)

References 6 publications

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“…DCR patients with a history of acute dacryocystitis had a nine times higher likelihood of having a dacryolith than DCR patients without a history of acute dacryocystitis in this series. Andreou and Rose [49] similarly found that patients with dacryoliths were more likely to have a history of dacryocystitis when compared with dacryolith-free patients. In addition, they reported that patients with stones sought treatment earlier than stone-free patients.…”

Section: Pathophysiology and Etiology Of Acquired Nasolacrimal Duct Omentioning

confidence: 87%

Acquired Nasolacrimal Duct Obstruction

Mills

Meyer

2006

Otolaryngologic Clinics of North America

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Section: Pathophysiology and Etiology Of Acquired Nasolacrimal Duct Omentioning

confidence: 87%

Acquired Nasolacrimal Duct Obstruction

Mills

Meyer

2006

Otolaryngologic Clinics of North America

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“…Acquired nasolacrimal duct obstruction is more common in females than males, resulting in the speculation that the obstruction is caused by gender-specific hormonal or anatomic differences. However, it was not possible to demonstrate a gender bias toward dacryolithiasis [2], with neither a female propensity reported by Hawes [3]nor a male preponderance reported by Yazici et al [1]. …”

Section: Introductionmentioning

confidence: 99%

Measurement of pH, Electrolytes and Electrophoretic Studies of Tear Proteins in Tears of Patients with Dacryoliths: A Novel Concept for Dacryoliths

Lee

Yun

2004

Ophthalmologica

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Dacryolithiasis is one of the causes of acquired nasolacrimal duct obstruction, although its origin is unclear. The purpose of this study was to investigate the differences in tear constituents between patients with nasolacrimal duct obstruction with dacryoliths and those without dacryoliths. In a prospective case-control study, undiluted tears were collected from 30 eyes from 30 patients with partial acquired nasolacrimal duct obstruction (PANDO) consisting of 17 PANDO patients with dacryoliths and 13 PANDO patients without dacryoliths. The pH, and the Na⁺, K⁺, Cl^–, total calcium and total protein concentrations were determined. The composition of the tear proteins was assessed by cellulose acetate electrophoresis. In the tear samples from 17 eyes with PANDO/dacryoliths, the mean ± SD K⁺ level was 15.6 ± 3.1 mEq/l. In the tear samples from 13 PANDO controls, the mean ± SD K⁺ level was 19.8 ± 4.9 mEq/l. The difference between the two groups was statistically significant (p = 0.02). In the tear samples from PANDO/dacryolith patients, the mean ± SD total protein level was 129.0 ± 72.9 mg/dl. In the tear samples from the PANDO controls the mean ± SD total protein level was 261.6 ± 132.5 mg/dl. The difference between the two groups was statistically significant (p = 0.00). In the tear protein fractions from electrophoresis, a low level of lysozyme was observed in the PANDO/dacryolith samples compared with the PANDO control samples (p = 0.03). The tears from patients with PANDO due to dacryoliths showed a change in the concentrations of electrolytes and protein, particularly lysozyme, compared with that of the patients with PANDO without dacryoliths, which may be related to the pathogenesis of dacryoliths.

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“…However, our results raise the question of whether TFF peptides per se influence dacryolith formation or whether their secretion, as in secretion of mucins and alpha factors have been suggested, such as increased frequency in females, patient age below 50 years, association with cigarette smoking and facial-sinonasal trauma, and increased frequency subsequent to previous occurrence of dacryocystitis [3,4,8,11,12,35]. However, there are also some contradictory studies that indicate increased frequency in males and patients aged above 50 years [1,37]. Dacryoliths usually become symptomatic when they obstruct the nasolacrimal system.…”

mentioning

confidence: 99%

TFF peptides and mucins are major components of dacryoliths

Paulsen

Schaudig

Fabian³

et al. 2006

Graefe's Arch Clin Exp Ophthalmo

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Dacryoliths consist partly of secreted mucins comparable with the mucin spectrum of the epithelium of healthy nasolacrimal ducts. Beside TFF1 and TFF3, both of which are produced under healthy circumstances, TFF2 is additionally induced and secreted in cases of dacryolithiasis. All three TFF peptides appear to be augmented in dacryoliths. With regard to their rheologic properties, TFF peptides may play a functional role in dacryolith formation. However, our results raise the question of whether TFF peptides per se influence dacryolith formation or whether their secretion, as in secretion of mucins and alpha defensins 1-3, is merely a secondary phenomenon.

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Clinical presentation of patients with dacryolithiasis

Cited by 18 publications

References 6 publications

Acquired Nasolacrimal Duct Obstruction

Acquired Nasolacrimal Duct Obstruction

Measurement of pH, Electrolytes and Electrophoretic Studies of Tear Proteins in Tears of Patients with Dacryoliths: A Novel Concept for Dacryoliths

TFF peptides and mucins are major components of dacryoliths

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