Clinical Presentation of Invasive Pneumococcal Disease in Spain in the Era of Heptavalent Conjugate Vaccine

Abstract

IPD continues to increase in Barcelona, and the rate is higher than previously reported as a result of low sensitivity of bacterial culture. Non-PCV7 serotypes were responsible for 91% of episodes and pneumonia was the main clinical presentation.

Targeted vaccination of teenagers following continued rapid endemic expansion of a single meningococcal group W clone (sequence type 11 clonal complex), United Kingdom 2015

“…This does not appear to be in line with previous observations, where pneumonia is the most commonly reported clinical presentation [15,35,36]. However, this difference is a consequence of the terms used to define clinical presentation in this report.…”

Clinical, biochemical and microbiological factors associated with the prognosis of pneumococcal meningitis in children

“…Taking the recent increase in pneumococcal serotypes with decreased sensitivity to multiple antibiotics into account, combined antibiotic treatment (cefotaxime plus vancomicyn) would be advisable in countries with high pneumococcal resistance rates. Moreover, it is well known that the rate of PM decreases with routine pneumococcal conjugate vaccination in children, 1,31,33,34,38,39 so this preventive measure against PM in children would be also advisable.…”

Changing trends in serotype distribution and antimicrobial susceptibility ofStreptococcus pneumoniaecausing invasive diseases in Central Thailand, 2009–2012

“…[1][2][3][4][5][6]8 The data from Active Bacterial Core surveillance (ABCs) in 2007 identified a total of 493 children aged <5 y with IPD after the successful PCV7 implementation in 2000. Among the 427 IPD cases with known serotype, 64% were caused by 6 additional serotypes contained in PCV13.…”