Clinical Presentation of Hospitalized Adult Patients With HIV Infection and AIDS in Bangkok, Thailand

Tansuphasawadikul, Somsit; Amornkul, Pauli N.; Tanchanpong, Chana; Limpakarnjanarat, Khanchit; Kaewkungwal, Jaranit; Likanonsakul, Sirirat; Eampokalap, Boonchuay; Naiwatanakul, Thananda; Kitayaporn, Dwip; Young, Nancy L.; Hu, Dale J.; Mastro, Timothy D.

doi:10.1097/00126334-199908010-00011

Cited by 51 publications

(43 citation statements)

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“…This is in accordance with the findings of the Ministry of Public Health of Thailand and other studies showing that heterosexual contact is the main mode of transmission in Thailand (80%) [3,[12][13][14][15]. These findings are different from those in the USA, where male-male sexual contact or IVDU were the most common risk factors [12].…”

Section: Discussion Demographicssupporting

confidence: 89%

Clinical features, aetiology and short-term outcome of interstitial pneumonitis in HIV/AIDS patients at Bamrasnaradura Hospital, Nonthaburi, Thailand

Knauer

Das

Tansuphasawadikul

et al. 2005

Wien Klin Wochenschr

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durchgeführt, um die klinischen Manifestationen, die Ätiologie und die kurzfristige Entwicklung von interstitieller Pneumonie bei HIV/AIDS Patienten zu beschreiben. 59 Patienten mit interstitieller Pneumonie wurden in die Studie eingeschlossen.Tuberkulose (TB) war die häufigste Diagnose (44%), gefolgt von Pneumocystis Pneumonie (PCP) (25,4%), bakterieller Pneumonie (20,3%), und Pilzpneumonie (10,2%).Bei TB waren folgende Ergebnisse statistisch signifikant: milder Husten (p = 0.031), Blässe (p = 0.021), Lymphadenopathie (p < 0.001), eine höhere durchschnittliche Körpertemperatur (p = 0.004) und das Fehlen von Dyspnoe (p = 0.042) sowie von Hautläsionen (p = 0.003).Bei PCP waren folgende Manifestationen statistisch signifikant: Dyspnoe (p = 0.014), apurulente Sputumproduktion (p = 0.047), eine höhere durchschnittliche Atemfrequenz (p < 0.001) und das Fehlen von Lymphadenopathie (p = 0.001).Bakterielle Pneumonie war durch folgende statistisch signifikanten Ergebnisse gekennzeichnet: purulente Sputumproduktion (p = 0.014), Hämoptyse (p = 0.006), Hautläsionen (p = 0.002) und schwerer Husten (p = 0.040).Bei Pilzpneumonie waren Kopfschmerzen und papulonekrotische Hautläsionen häufig, jedoch war keiner dieser Faktoren statistisch signifikant.Nach einem vierwöchigen Beobachtungszeitraum waren 59,3% der Patienten am Leben und 13,6% verstorben. Bei 88,6% der Überlebenden hatte sich der klinische Zustand verbessert. Die kumulative Überlebensrate war am höchsten bei PCP, gefolgt von bakterieller Pneumonie, TB und Pilzpneumonie (p = 0.453). in order to describe the clinical manifestations and determine the aetiologies as well as to assess the short term outcome of interstitial pneumonitis in HIV/ AIDS patients. 59 patients with interstitial infiltrates on chest radiographs were included in the study.Tuberculosis (TB) was the most common diagnosis (44%), followed by Pneumocystis pneumonia (PCP) (25.4%), bacterial pneumonia (20.3%) and fungal pneumonia (10.2%).In TB, compared to other diagnoses, a mild cough (p = 0.031), pallor (p = 0.021), lymphadenopathy (p < 0.001), an absence of skin lesions (p = 0.003), a higher mean body temperature (p = 0.004) and an absence of dyspnoea on exertion (p = 0.042) were significant findings.In PCP, compared to other diagnoses, dyspnoea on exertion (p = 0.014), non-purulent sputum production (p = 0.047), a higher mean respiratory rate (p < 0.001), and an absence of lymphadenopathy (p < 0.001) were significant factors.In bacterial pneumonia, compared to other diagnoses, production of purulent sputum (p = 0.014), haemoptysis (p = 0.006), skin lesions (p = 0.002) and severe cough (p = 0.040) were significantly associated factors.In fungal pneumonia, compared to other diagnoses, headache and papulonecrotic skin lesions were common findings, but no factor showed a significant association.After four weeks, 59.3% patients were alive and 13.6% had died. Among those alive 88.6% had clinically improved. The cumulative survival after 28 days was Knauer et al., Interstitial pneumonitis in HIV/AIDS patients ...

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Section: Discussion Demographicssupporting

confidence: 89%

Clinical features, aetiology and short-term outcome of interstitial pneumonitis in HIV/AIDS patients at Bamrasnaradura Hospital, Nonthaburi, Thailand

Knauer

Das

Tansuphasawadikul

et al. 2005

Wien Klin Wochenschr

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“…Vietnamese researchers reported a 28% mortality rate among IV in-patients in 2004 [10]. A similar rate was observed in Thailand (25.5%), where antiretroviral treatment was reported in only 93 (4.1%) patients during their hospital stay [11].…”

Section: Discussionmentioning

confidence: 62%

Outcome and Predictive Factors of Mortality in Hospitalized HIV-Patients in Burkina Faso

et al. 2009

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Females are admitted to hospital earlier than males, probably as an indirect result of the Prevention of Mother-to-Child Transmission (PMTCT) public health initiative. An active search of HIV status in other members of the family (PMTCT-plus) may result in the detection of asymptomatic HIV-infected patients as well. A Plasmodium falciparum-positive smear during admission significantly impacted on outcome as well as low platelet count.

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“…Clinical data from Thailand generally have been restricted to a description of cases from individual hospitals [8][9][10]. This report describes the nationwide distribution and regional variation of specific clinical illnesses and demographic and behavioral risk characteristics of 1100,000 persons with AIDS who were reported to the Division of Epidemiology of the MOPH from January 1994 through December 1998.…”

mentioning

confidence: 99%

Clinical Presentation and Risk Behaviors of Patients with Acquired Immunodeficiency Syndrome in Thailand, 1994-1998: Regional Variation and Temporal Trends

Chariyalertsak

Sirisanthana

Saengwonloey

et al. 2001

Clinical Infectious Diseases

125

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From 1994 through 1998, the clinical and demographic features and risk behaviors of 101,945 adolescent and adult patients with acquired immunodeficiency syndrome (AIDS) were reported to the Ministry of Public Health in Thailand. The number of reported cases of AIDS infection increased from 12,005 in 1994 to 24,722 in 1997. Nearly 40% of the cases were reported from the northern provinces, whichcontained only approximately 20% of the adult population. About 80% of cases were among male patients, and 87% had been acquired via sexual contact. Tuberculosis was the most commonly reported opportunistic infection, occurring in 28.9% of patients; it was more commonly reported among injection drug abusers, especially in Bangkok. Pneumocystis carinii pneumonia and cryptococcal meningitis each occurred in nearly 20% of patients and were more frequently reported in patients with risk factors related to sex than in injection drug abusers. Penicillium marneffei infections were reported in 6.8% of patients from the northern provinces but less frequently elsewhere. These data suggest that AIDS is common in Thailand, and human immunodeficiency virus-infected persons should be given prophylaxis for tuberculosis, fungal infections, and P. carinii pneumonia.

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Clinical Presentation of Hospitalized Adult Patients With HIV Infection and AIDS in Bangkok, Thailand

Cited by 51 publications

References 24 publications

Clinical features, aetiology and short-term outcome of interstitial pneumonitis in HIV/AIDS patients at Bamrasnaradura Hospital, Nonthaburi, Thailand

Clinical features, aetiology and short-term outcome of interstitial pneumonitis in HIV/AIDS patients at Bamrasnaradura Hospital, Nonthaburi, Thailand

Outcome and Predictive Factors of Mortality in Hospitalized HIV-Patients in Burkina Faso

Clinical Presentation and Risk Behaviors of Patients with Acquired Immunodeficiency Syndrome in Thailand, 1994-1998: Regional Variation and Temporal Trends

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