Clinical Presentation of Hepatocellular Carcinoma in African Americans vs. Caucasians: A Retrospective Analysis

Samant, Hrishikesh; Kohli, Kapil; Patel, Krunal; Shi, Runhua; Jordan, Paul; Morris, James; Schwartz, Annie; Alexander, Jonathan

doi:10.3390/pathophysiology28030026

Cited by 3 publications

(2 citation statements)

References 43 publications

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“…Important risk factors for hepatocellular carcinoma include viral hepatitis B or viral hepatitis C, alcoholic liver disease, nonalcoholic fatty liver disease, and so on [ 4 , 5 ]. Approximately 80%–90% of patients with cirrhosis develop liver cancer [ 6 ]. Therefore, it is very important to explore the occurrence, development, and potential molecular mechanism of liver cancer.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of PDZK1 in Hepatocellular Carcinoma Complicated with Hyperuricemia

Guo

Jiang

Quan

et al. 2022

Journal of Oncology

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Background. Hepatocellular carcinoma (HCC) is a kind of primary liver cancer that accounts for more than 90% of primary hepatocellular carcinomas. Hyperuricemia is closely related to the development, recurrence, metastasis, and prognosis of cancer. Previous studies have proved that the serum uric acid level can increase the incidence rate and mortality of malignant tumors. However, the specific pathogenesis remains unstudied. Methods. RT-qPCR analysis showed that the mRNA expression of PDZK1 and ABCG2 increased significantly after HCC cells were exposed to different concentrations of soluble uric acid (2.5, 5, 10, 20 mg/dl) for 24 hours. Then, in HCC shRNAs, PDZK1, or over expression PDZK1 were used. CCK8, wound healing, and Transwell assay showed that PDZK1 regulates cell proliferation, invasion, and migration. Flow cytometry results revealed that PDZK1 affects cell apoptosis. Western blot results show that PDZK1 affects the STAT3/C-myc pathway. Then, in vivo tumorigenesis, allopurinol maybe an effective drug to advance: the prognosis of HCC. Results. In our study, RT-qPCR analysis showed that the mRNA expression of PDZK1 and ABCG2 increased significantly after different concentrations of soluble uric acid in HCC. Then, PDZK1 affects the proliferation, migration, and apoptosis of HCC through the STAT3/C-myc pathway. Conclusions. Hyperuricemia response affects the expression of PDZK1; PDZK1 affects the proliferation, migration, and apoptosis through the STAT3/C-myc pathway in hepatocellular carcinoma. It is suggested that PDZK1 maybe closely related to the occurrence, development, and prognosis of HCC and allopurinol maybe have potential anticancer effects.

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Section: Introductionmentioning

confidence: 99%

Mechanism of PDZK1 in Hepatocellular Carcinoma Complicated with Hyperuricemia

Guo

Jiang

Quan

et al. 2022

Journal of Oncology

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“…Additionally, assessing the impact of socioeconomic factors and examining how clinical cofactors such as NAFLD and alcohol use interact among different groups may provide insights into the variations in HCC incidence. This information can guide the development and implementation of interventions aimed at addressing these aforementioned factors along the HCC care pathway [43] . The goal is ultimately improving the effectiveness and sustainability of policies focused on achieving health equity.…”

Section: Socioeconomics and Physical/built Environmentmentioning

confidence: 99%

Racial, ethnic, and socioeconomic differences in hepatocellular carcinoma across the United States

Diaz,

Ruff,

Pawlik

2024

Hepatoma Res

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Hepatocellular carcinoma (HCC) poses a significant public health challenge within the US, exerting an increasingly substantial influence on cancer-related deaths. However, the HCC burden is not uniformly distributed, with significant disparities related to race, ethnicity, and socioeconomic status. This manuscript comprehensively reviews the multifaceted origins of HCC disparities, exploring their roots in the sociocultural environment, socioeconomics, the physical/built environment, and the healthcare/political systems. The sociocultural environment highlights the unique challenges faced by racial and ethnic minority populations, including language barriers, cultural beliefs, and limited healthcare access. The socioeconomics and the physical/built environment section emphasize the impact of neighborhood poverty, geographic disparities, and healthcare infrastructure on HCC outcomes. The healthcare and political systems play a pivotal role in driving HCC disparities through practice guidelines, healthcare policies, insurance coverage, and access to care. Inconsistent practice guidelines across specialties and variations in insurance coverage contribute to disparities in HCC surveillance and treatment. In conclusion, addressing HCC disparities requires a multifaceted, patient-centered approach that includes cultural competence, infrastructure enhancements, policy changes, and improved access to care. Collaborative efforts among healthcare professionals, researchers, policymakers, and institutions are essential to reducing the burden of HCC on marginalized communities and ensuring equitable care for all individuals affected by this complex disease.

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Addressing racial and ethnic disparities in US liver cancer care

Kim

Cravero

VoPham

et al. 2023

Hepatology Communications

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HCC, the most common form of primary liver cancer, is the fastest rising cause of cancer-related death in the United States. HCC disproportionately affects racial and ethnic minorities in the United States. A practical framework is needed to organize the complex patient, provider, health system, and societal factors that drive these racial and ethnic disparities. In this narrative review, we adapted and applied the National Institute on Minority Health and Health Disparities (NIMHD) Research Framework to the HCC care continuum, as a step toward better understanding and addressing existing HCC-related disparities. We first summarize the literature on HCC-related disparities by race and ethnicity organized by the framework’s 5 domains (biological, behavioral, physical/built environment, sociocultural environment, and health care system) and 4 levels (individual, interpersonal, community, and societal) of influence. We then offer strategies to guide future research initiatives toward promotion of health equity in HCC care. Clinicians and researchers may help mitigate further inequities and better address racial and ethnic disparities in HCC care by prioritizing the following in HCC research: (1) increasing racial and ethnic minority representation, (2) collecting and reporting HCC-related data by racial and ethnic subgroups, (3) assessing the patient experience of HCC care by race and ethnicity, and (4) evaluating HCC-specific social determinants of health by race and ethnicity. These 4 priorities will help inform the development of future programs and interventions that are tailored to the unique experiences of each racial and ethnic group.

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Clinical Presentation of Hepatocellular Carcinoma in African Americans vs. Caucasians: A Retrospective Analysis

Cited by 3 publications

References 43 publications

Mechanism of PDZK1 in Hepatocellular Carcinoma Complicated with Hyperuricemia

Mechanism of PDZK1 in Hepatocellular Carcinoma Complicated with Hyperuricemia

Racial, ethnic, and socioeconomic differences in hepatocellular carcinoma across the United States

Addressing racial and ethnic disparities in US liver cancer care

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