Clinical presentation of GB-C virus infection in drug abusers with chronic hepatitis C

Goeser, Tobias; Seipp, Stefanie; Wahl, Rafael; Müller, Hubert M.; Stremmel, Wolfgang; Theilmann, Lorenz

doi:10.1016/s0168-8278(97)80413-8

Cited by 28 publications

(15 citation statements)

References 17 publications

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“…As reported in the adult patient literature [5,14,22], GBV-C affects up to one third of children with parenteral-transmitted HCV infection [6,9,11,20]. Few data are available on GBV-C infection in pediatric patients with mother-to-child-transmitted HCV infection, in whom we demonstrate a prevalence of 13.2% for GBV-C viremia, lower than previously reported levels (from 20% to 34%) [6,9,11,20].…”

Section: Discussioncontrasting

confidence: 50%

The prevalence of GB virus C/hepatitis G virus RNA among healthy and HCV-infected Catalan children

et al. 2007

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GB virus C (GBV-C) is a blood-borne flavivirus. The prevalence of GBV-C viremia among healthy adults is 0.5% to 4% and, to date, no disease has been definitely associated with GBV-C infection. We conducted a cross-sectional study to evaluate GBV-C viremia prevalence in a group of 327 healthy children with normal alanine amino transferase (ALT) levels (Group A) and elevated ALT levels (Group B) of unknown origin, and among 38 pediatric patients with mother-to-child-transmitted hepatitis C virus (HCV) infection (Group C). No statistically significant differences were observed between prevalences in Groups A and B (2.2% vs 6.7%, p = 0.06). None of the children in Groups A or B who tested positive for GBV-C RNA showed any clinical symptoms. The prevalence of GBV-C viremia in Group A was lower than for patients in Group C (2.2% vs 13.2%, p = 0.007); no differences were observed in HCV infection characteristics between those patients who were co-infected with GBV-C and those who were not. In conclusion, while GBV-C viremia is more frequent among HCV-infected pediatric patients, it is neither associated with liver disease nor has any influence on HCV-related chronic hepatitis.

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Section: Discussioncontrasting

confidence: 50%

The prevalence of GB virus C/hepatitis G virus RNA among healthy and HCV-infected Catalan children

et al. 2007

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“…Like hepatitis C virus, HGV can be transmitted by blood and blood products and appears to have a worldwide distribution [1, 2, 3, 4, 5, 6, 7]. Preliminary data suggest a 1–4% prevalence among blood donors in the US and Europe, up to 16% in patients with hepatitis B or C, and up to 24–50% in intravenous drug addicts [2, 4, 6, 8, 9, 10, 11, 12]. The clinical implications of HGV are still unclear.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological and Clinical Aspects of Hepatitis G Virus Infection in Blood Donors and Immunocompromised Recipients of HGV-Contaminated Blood

et al. 1998

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Background and objectives: The infectiousness and clinical relevance of the newly discovered blood-borne Flaviviridae-like agent, termed hepatitis G virus (HGV), are not well understood. Materials and methods: Twenty-three transfusion recipients of two HGV-affected long-term blood donors were studied for HGV genome and antibodies to the putative envelope 2 glycoprotein (anti-E2) of HGV. Nine recipients had nonhematological disorders and 14 suffered from severe hematological diseases and 7 of them received allogeneic bone marrow or blood stem cell transplantation. The molecular epidemiology of the observed HGV infection was studied by direct sequencing of parts of the 5′-noncoding region, NS3, and NS5 region of HGV in the 2 long-term donors and in their 6 recipients who became HGV RNA positive. Additionally, 549 individuals – homologous (n = 254) and autologous blood donors (n = 202), and medical staff (n = 89) – were investigated for the presence of HGV RNA. Results: HGV RNA in serum was found in 15 of the 23 (65%) transfusion recipients with known exposure of HGV-contaminated blood. Seven of the remaining 8 recipients showed only an anti-E2 response, indicating previous HGV infection with spontaneous clearance of the virus. In one recipient neither HGV RNA nor anti-E2 could be detected. Molecular evidence for HGV transmission by the 2 donors was found in 3 of the 6 recipients studied. The alanine aminotransferase levels were not significantly different in the HGV RNA positive and negative recipients, and none of the 23 recipients developed posttransfusion hepatitis. Persistent HGV infection was observed especially in recipients with severe hematological disorders or in those in whom intensive immunosuppressive treatment was necessary. Of the 549 individuals studied, 10 (1.8%) were healthy carriers of HGV RNA. Conclusion: The persistence of transfusion-acquired HGV infection is not associated with acute or chronic hepatitis, but may be influenced by the recipient’s underlying disease.

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“…In a recent series of similar coinfected patients, 40/70 underwent a liver biopsy. No differences were found between patients with and without HGV coinfection 26. In addition, there was no obvious effect on long term graft function in 39 patients with non-A–C hepatitis despite an increased prevalence of HGV infection after liver transplantation 27…”

Section: Discussionmentioning

confidence: 97%

Hepatic histology in hepatitis C virus carriers coinfected with hepatitis G virus

Petrík

Guella

Wight

et al. 1998

Gut

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Background-A novel flavivirus has been described recently and designated hepatitis G virus (HGV). The virus is transmitted by the parenteral route but it is uncertain whether it is associated with chronic liver disease because liver biopsy is diYcult to justify in this group. Aims-To examine histological features of liver biopsy in patients infected with hepatitis C virus (HCV) according to the presence or absence of HCV and HGV RNA. Methods-One hundred and thirty one consecutive HCV carriers undergoing staging liver biopsy were studied retrospectively. In each, HCV RNA and HGV RNA were detected by reverse transcription polymerase chain reaction on serum samples collected at the time of biopsy. The presence of each RNA was correlated with histological features blind to the RNA results; individual histological features of inflammation or fibrosis were scored separately. Results-Nineteen patients were positive for both HGV and HCV RNA in serum, 91 were positive for HCV RNA alone, two were positive for HGV RNA alone, and 19 were negative for both RNA species. Neither age nor sex diVered between the groups; a greater proportion of intravenous drug users were HGV RNA positive, but this was not statistically significant. There was no eVect of HGV coinfection on the stage of fibrosis or any other histological parameter except steatosis; patients with HCV and HGV RNA had a higher mean score for fat than those patients with HCV RNA alone (p<0.05). Conclusions-HGV coinfection has no important eVects on histological features in chronic HCV carriers. It is unlikely that HGV infection causes chronic liver disease. (Gut 1998;42:103-106)

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Clinical presentation of GB-C virus infection in drug abusers with chronic hepatitis C

Cited by 28 publications

References 17 publications

The prevalence of GB virus C/hepatitis G virus RNA among healthy and HCV-infected Catalan children

The prevalence of GB virus C/hepatitis G virus RNA among healthy and HCV-infected Catalan children

Epidemiological and Clinical Aspects of Hepatitis G Virus Infection in Blood Donors and Immunocompromised Recipients of HGV-Contaminated Blood

Hepatic histology in hepatitis C virus carriers coinfected with hepatitis G virus

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