Clinical Presentation and Prognostic Factors

Moppett, John; Dommett, Rachel

doi:10.1007/978-3-319-39708-5_2

Cited by 2 publications

(3 citation statements)

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“…11 Other variables that confer a worse prognosis for ALL include age >10 years, higher white cell count at diagnosis, male sex, presence of central nervous system disease, and T-cell ALL. 2…”

Section: Discussionmentioning

confidence: 99%

“…1 The disease causes a decrease in hematopoiesis, so children often present with symptoms related to anemia, thrombocytopenia, and leukopenia. 2 The classic triad of easy bruising, lethargy, and fever is present in only approximately one-quarter of patients. Other typical symptoms include musculoskeletal pains (especially leg pain), anorexia, and abdominal pain.…”

Section: Introductionmentioning

confidence: 99%

“…Common physical examination findings, in addition to purpura, fever, and pallor, are hepatomegaly, splenomegaly, and lymphadenopathy. 2 We present the case of a patient with suspected bilateral osteomyelitis that demonstrates the need to consider malignancy and perform a workup for leukemia in children who present with persistent bone pain and fever.…”

Section: Introductionmentioning

confidence: 99%

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Fever and Leg Pain: Consider ALL the Diagnoses

Desmond¹,

Fletcher

Warrier

2019

TOJ

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Background: Acute lymphoblastic leukemia (ALL) is the most common childhood cancer diagnosed in the United States. The disease causes a decrease in hematopoiesis, so children often present with symptoms related to anemia, thrombocytopenia, and leukopenia. Symptoms for this malignancy may have significant overlap with other conditions such as osteomyelitis. Case Report: A 2-year-old male with no significant medical history presented with lower extremity pain and fever. Initial investigations, including imaging and complete blood count, led physicians to diagnose bilateral osteomyelitis. The patient was prescribed a course of antibiotics; however, his symptoms returned. Eventually, a bone marrow aspiration showed CD99 membrane-positive small round blue cell tumors. The patient was diagnosed with ALL. He was successfully treated with chemotherapy and is now in remission. Conclusion: This case demonstrates the importance of a broad differential diagnosis for a child presenting with leg pain and fever.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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