Clinical Presentation and Outcome of Bladder Schistosoma–Unrelated Squamous Cell Carcinoma: Report on 33 Consecutive Cases

Riadh, Ben Slama Mohamed; Atat, Rabii El; Sfaxi, Mohamed; Derouiche, A.; Kourda, Nadia; Chébil, Mohamed

doi:10.3816/cgc.2007.n.027

Cited by 6 publications

(6 citation statements)

References 15 publications

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“…So far, the clinical management of patients with squamous differentiated bladder cancer is limited by the choice of effective (neo) adjuvant therapies [13][14][15]. The five year survival rate is worse varying between 16 and 48% [22,23]. A ray of hope might be immunotherapy by PD1/PD-L1 checkpoint inhibitors which recently revolutionized the therapeutic landscape of various cancers including urothelial cancer [24].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic implications of PD-L1 expression in bladder cancer with squamous differentiation

et al. 2020

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Background: Immune checkpoint inhibitors (ICI) are an integral part of bladder cancer therapy, however, the relevance of ICI treatment for mixed and pure squamous cell carcinoma of the bladder remains poorly studied. Therefore, we analysed the expression of programmed death-ligand 1 (PD-L1) in urothelial carcinomas with squamous differentiation (UC/SCC) and pure squamous cell carcinoma (SCC) of the bladder and studied a UC/SCC patient with ICI therapy. Methods: Tissue microarrays of 45 UC/SCC and 63 SCC samples were immunohistochemically stained with four anti-PD-L1 antibodies (28-8, 22C3, SP142 and SP263). PD-L1 expression was determined for tumour cells (TP-Score), immune cells (IC-Score) and combined (CPS, combined positive score). In addition, we present clinical and histological data of an UC/SCC patient with nivolumab therapy. Results: Overall, positive PD-L1 staining ranged between 4.8 and 61.9% for IC and 0 and 51.2% for TC depending on the used antibody. There were no significant differences between UC/SCC and SCC. According to current FDA guidelines for example for first line therapy of urothelial cancer with pembrolizumab (CPS ≥ 10), a subset of SCC patients up to 20% would be eligible. Finally, our UC/SCC index patient revealed excellent therapy response regarding his lung metastasis. Conclusions: Our data reveal a PD-L1 expression in squamous differentiated carcinomas comparable with current data shown for urothelial tumours. In accordance with the encouraging clinical data of the index patient we suggest ICI treatment also for mixed and pure SCC of the urinary bladder.

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Section: Discussionmentioning

confidence: 99%

Therapeutic implications of PD-L1 expression in bladder cancer with squamous differentiation

et al. 2020

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“…Squamous cell carcinoma comprises 1.2-6.7% of all bladder tumours, [1][2][3] associated with transitional cell carcinoma of the bladder are more commonly seen than pure squamous cell carcinoma. It is more common in men, occurring at a mean age of 59-71 years.…”

Section: Urological Pathology Causing Free Air Under the Diaphragm? Dmentioning

confidence: 99%

“…It is more common in men, occurring at a mean age of 59-71 years. [1][2][3] The majority of patients present with haematuria, others with irritative lower urinary tract symptoms. Most tumours are advanced at presentation and moderately to poorly differentiated.…”

Section: Urological Pathology Causing Free Air Under the Diaphragm? Dmentioning

confidence: 99%

“…Keratinising squamous metaplasia is a premalignant condition 4 associated with invasive squamous cell carcinoma and results from chronic irritative stimuli involving the bladder namely bladder stones, recurrent urinary tract infections and chronic in-dwelling urinary catheters. 2,4 Squamous cell carcinoma developing secondary to implantation of PTFE in the bladder in the absence of chronic/recurrent urinary tract infection has also been reported.…”

Section: Urological Pathology Causing Free Air Under the Diaphragm? Dmentioning

confidence: 99%

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Urological pathology causing free air under the diaphragm?

Chitale

Debbarma²,

Wilson³

et al. 2008

Ann R Coll Surg Engl

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“…Several predisposing factors like chronic cystitis, radiation exposure, chronic indwelling catheters, neurogenic bladder, cigarette smoking and bladder calculi have been described 1,2 . Bladder calculus is the most common predisposing cause for schistosoma‐unrelated SCC bladder 3 . We report a case of SCC of bladder arising due to neglected bladder calculus.…”

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confidence: 94%