Clinical presentation and morbidity of contact lens–associated microbial keratitis: a retrospective study

Hoddenbach, Johan G; Boekhoorn, Sharmila S.; Wubbels, René J.; Vreugdenhil, W.; Rooij, Jeroen van; Geerards, Annette J M

doi:10.1007/s00417-013-2514-1

Cited by 54 publications

(71 citation statements)

References 24 publications

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“…Our results are close to those reported in the majority of series [1] [3]. The corneal abscess was unifocal in 24 cases (86.2%) and centrally located in 20 cases (69%) with an average diameter of 3.9 mm (range: 1to10 mm).…”

Section: Discussionsupporting

confidence: 89%

“…This period was less than or equal to 7 days in 69% of cases. In the literature, the average consultation period was 4.6 days in the Netherlands as discussed by Hoddenbach [1], 2 days in France as cited by Bourcier [13] and 5 days in a Moroccan study realized by Benhmidoune and et al [3]. The corneal abscess in our series was unilateral in all cases (100%).…”

Section: Discussionsupporting

confidence: 46%

“…The positive diagnosis of contact lens-related infectious keratitis is clinical. The diagnosis of the causative germ may be oriented by clinical presentation, but it is only certain in case of microbiological evidence from corneal sampling [1] [2] [3]. The treatment is mainly based on adapted anti-infectious eye drops.…”

Section: Introductionmentioning

confidence: 99%

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Contact Lens-Related Infectious Keratitis: Review of 29 Cases

Khochtali¹,

Daldoul²,

Zina³

et al. 2017

OALib

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Aim: To describe the epidemiological, clinical, microbiological and therapeutic features of corneal abscesses related to Contact Lens (CL) wear. Patients and Methods: Retrospective review of 29 patients (29 eyes) with infectious keratitis associated with contact lens wearing was conducted at Ophthalmology Department Fattouma Bourguiba University Hospital of Monastir, Tunisia between January 2006 and June 2016. All patients underwent detailed ophthalmological examination. Slit lamp examination and corneal culture were performed on all patients. The Contact Lens and Contact Lens cases were also analyzed if available. The mean follow-up period was 88 days (range: 30 -360 days). Results: The mean age of our patients was 27 year old. Twenty-three patients (97.3%) were females and 6 patients (20.7%) were males. Twenty-seven patients (93.1%) were soft contact lens users. The mean initial Visual Acuity (VA) was 20/1000. Stromal infiltrates were associated with ulcers in all cases, and were located in central cornea in 21 cases (72.4%). Hypopyon was noted in 10 cases (34.5%). Microbial cultures were positive in 18 patients (72.4%). Pseudomonas aeruginosa was isolated in 41.4% of cases. Amoebic cysts were found in 5 cases (17.3%). Fusarium was isolated in one eye (3.5%). Antimicrobial treatment was based on the suspected or isolated causative agent. Final VA was 20/125. Conclusion: Corneal abscesses are a rare but serious complication of CL wear. Educating CL users, early diagnosis and appropriate management are important elements so as to reduce ocular morbidity.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 46%

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Contact Lens-Related Infectious Keratitis: Review of 29 Cases

Khochtali¹,

Daldoul²,

Zina³

et al. 2017

OALib

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“…This infection can be managed and treated with a course of antibiotics such as second-generation fluoroquinolones, Moxifloxacin and Gatifloxacin. [108][109][110] The retrospective study conducted by Johan et al, 111 at Rotterdam Eye Hospital evaluated the epidemiological characteristics, clinical presentation, isolated organism, and treatment for all hospitalised patients with CLMK. The study also revealed that more than 65% of the isolated microorganisms were Pseudomonas aeruginosa with 2.7% and 1.3% resistance to gentamicin and ofloxacin respectively.…”

Section: Contact Lens-associated Microbial Keratitis (Clmk)mentioning

confidence: 99%

“…The study also revealed that more than 65% of the isolated microorganisms were Pseudomonas aeruginosa with 2.7% and 1.3% resistance to gentamicin and ofloxacin respectively. 111 Almost 65% of the admitted cases showed best corrected visual acuity (BCVA) lower than 0.05 Snellen. Other pathogens such as acanthamoeba and fungi were also reported to be associated with CLMK.…”

Section: Contact Lens-associated Microbial Keratitis (Clmk)mentioning

confidence: 99%

Contact Lenses: Clinical Evaluation, Associated Challenges and Perspectives

Mosuela¹,

Thapa²,

Alany³

et al. 2017

PPIJ

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Esculentin‐1a derived peptides kill Pseudomonas aeruginosa biofilm on soft contact lenses and retain antibacterial activity upon immobilization to the lens surface

et al. 2018

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Contact lens (CL) wear is a risk factor for development of microbial keratitis, a vision threatening infection of the eye. Adverse events associated with colonization of lenses, especially by the multi-drug resistant and biofilm forming bacterium Pseudomonas aeruginosa remain a major safety issue. Therefore, novel strategies and compounds to reduce the onset of CL-associated ocular infections are needed. Recently, the activity of the frog skin-derived antimicrobial peptide Esc(1-21) and its diastereomer Esc(1-21)-1c was evaluated against both planktonic and sessile forms of this pathogen. Furthermore, Esc(1-21) was found to significantly reduce the severity of P. aeruginosa keratitis in a mouse model and preserve antipseudomonal activity in the presence of human basal tears. Here, we have analyzed the activity of the peptides on P. aeruginosa biofilm formed on soft CLs. Microbiological assays and scanning electron microscopy analysis indicated that the peptides were able to disrupt the bacterial biofilm, with the diastereomer having the greater efficacy (up to 85% killing vs no killing at 4 μM for some strains). Furthermore, upon covalent immobilization to the CL, the two peptides were found to cause more than four log reduction in the number of bacterial cells within 20 minutes and to reduce bacterial adhesion to the CL surface (77%-97% reduction) in 24 hours. Importantly, peptide immobilization was not toxic to mammalian cells and did not affect the lens characteristics. Overall, our data suggest that both peptides have great potential to be developed as novel pharmaceuticals for prevention and treatment of CL-associated P. aeruginosa keratitis.

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Clinical presentation and morbidity of contact lens–associated microbial keratitis: a retrospective study

Cited by 54 publications

References 24 publications

Contact Lens-Related Infectious Keratitis: Review of 29 Cases

Contact Lens-Related Infectious Keratitis: Review of 29 Cases

Contact Lenses: Clinical Evaluation, Associated Challenges and Perspectives

Esculentin‐1a derived peptides kill Pseudomonas aeruginosa biofilm on soft contact lenses and retain antibacterial activity upon immobilization to the lens surface

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