Clinical presentation and laboratory findings for the first autochthonous cases of dengue fever in Madeira island, Portugal, October 2012

Alves, Maria João; Fernandes, P.L.; Amaro, Fátima; Osório, Hugo Costa; Luz, Teresa Elane Bezerra; Parreira, P.; Andrade, Gabriella Linhares de; Zé-Zé, Líbia; Zeller, H.

doi:10.2807/ese.18.06.20398-en

Cited by 58 publications

(9 citation statements)

References 9 publications

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“…In 2012, island residents experienced their first cases of autochthonous dengue infection, spread by Ae. aegypti mosquitoes [ 42 ]. The expansion of Ae.…”

Section: Discussionmentioning

confidence: 99%

Global Distribution of Aedes aegypti and Aedes albopictus in a Climate Change Scenario of Regional Rivalry

Laporta

Potter

Oliveira

et al. 2023

Insects

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Arboviral mosquito vectors are key targets for the surveillance and control of vector-borne diseases worldwide. In recent years, changes to the global distributions of these species have been a major research focus, aimed at predicting outbreaks of arboviral diseases. In this study, we analyzed a global scenario of climate change under regional rivalry to predict changes to these species’ distributions over the next century. Using occurrence data from VectorMap and environmental variables (temperature and precipitation) from WorldClim v. 2.1, we first built fundamental niche models for both species with the boosted regression tree modelling approach. A scenario of climate change on their fundamental niche was then analyzed. The shared socioeconomic pathway scenario 3 (regional rivalry) and the global climate model Geophysical Fluid Dynamics Laboratory Earth System Model v. 4.1 (GFDL-ESM4.1; gfdl.noaa.gov) were utilized for all analyses, in the following time periods: 2021–2040, 2041–2060, 2061–2080, and 2081–2100. Outcomes from these analyses showed that future climate change will affect Ae. aegypti and Ae. albopictus distributions in different ways across the globe. The Northern Hemisphere will have extended Ae. aegypti and Ae. albopictus distributions in future climate change scenarios, whereas the Southern Hemisphere will have the opposite outcomes. Europe will become more suitable for both species and their related vector-borne diseases. Loss of suitability in the Brazilian Amazon region further indicated that this tropical rainforest biome will have lower levels of precipitation to support these species in the future. Our models provide possible future scenarios to help identify locations for resource allocation and surveillance efforts before a significant threat to human health emerges.

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“…In 2012, island residents experienced their first cases of autochthonous dengue infection, spread by Ae. aegypti mosquitoes [ 42 ]. The expansion of Ae.…”

Section: Discussionmentioning

confidence: 99%

Global Distribution of Aedes aegypti and Aedes albopictus in a Climate Change Scenario of Regional Rivalry

Laporta

Potter

Oliveira

et al. 2023

Insects

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“…Consequently, the number of dengue infections has increased worldwide over the last decades, with the occurrence of serious outbreaks with haemorrhagic fever [3]. In the African archipelago of Cape Verde, the first dengue epidemic, with 21,000 cases in 2009, demonstrated that dengue virus is still expanding into new territories [4][5]. In 2012, an outbreak of dengue fever in Madeira Island was reported [6], which proves that this infection is not only confined to the tropical region.…”

mentioning

confidence: 99%

Larvicidal Activity againstAedes Aegyptiof Foeniculum Vulgare Essential Oils from Portugal and Cape Verde

Rocha

Matosc²,

Novoa

et al. 2015

Natural Product Communications

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Dengue is a potentially fatal mosquito-borne infection with 50 million cases per year and 2.5 billion people vulnerable to the disease. This major public health problem has recurrent epidemics in Latin America and occurred recently in Cape Verde and Madeira Island. The lack of anti-viral treatment or vaccine makes the control of mosquito vectors a high option to prevent virus transmission. Essential oil (EO) constituents can affect insect's behaviour, being potentially effective in pest control. The present study evaluated the potential use of Foeniculum vulgare (fennel) EO in the control of the dengue vector Aedes aegypti. EOs isolated from fennel aerial parts collected in Cape Verde and from a commercial fennel EO of Portugal were analysed by NMR, GC and GC-MS. trans-Anethole (32 and 30%, respectively), limonene (28 and 18%, respectively) and fenchone (10% in both cases) were the main compounds identified in the EOs isolated from fennel from Cape Verde and Portugal, respectively. The larvicidal activity of the EOs and its major constituents were evaluated, using WHO procedures, against third instar larvae of Ae. aegypti for 24 h. Pure compounds, such as limonene isomers, were also assayed. The lethal concentrations LC 50 , LC 90 and LC 99 were determined by probit analysis using mortality rates of bioassays. A 99% mortality of Ae. aegypti larvae was estimated at 37.1 and 52.4 µL L-l of fennel EOs from Cape Verde and Portugal, respectively. Bioassays showed that fennel EOs from both countries displayed strong larvicidal effect against Ae. aegypti, the Cape Verde EO being as active as one of its major constituents, (-)-limonene.

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“…Globalization of trade and travel, besides increasing the virus distribution area, also prompts the spread of the vector worldwide, together with climate change. , Aedes spp. mosquitoes reach now temperate regions, including North America and Europe. − This resulted in recent autochthonous DENV transmission in France, Croatia, and Portugal (Madeira island), demonstrating the disease global reach. − …”

mentioning

confidence: 99%

Understanding Dengue Virus Capsid Protein Disordered N-Terminus and pep14-23-Based Inhibition

et al. 2014

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Dengue virus (DENV) infection affects millions of people and is becoming a major global disease for which there is no specific available treatment. pep14-23 is a recently designed peptide, based on a conserved segment of DENV capsid (C) protein. It inhibits the interaction of DENV C with host intracellular lipid droplets (LDs), which is crucial for viral replication. Combining bioinformatics and biophysics, here, we analyzed pep14-23 structure and ability to bind different phospholipids, relating that information with the full-length DENV C. We show that pep14-23 acquires α-helical conformation upon binding to negatively charged phospholipid membranes, displaying an asymmetric charge distribution structural arrangement. Structure prediction for the N-terminal segment reveals four viable homodimer orientations that alternatively shield or expose the DENV C hydrophobic pocket. Taken together, these findings suggest a new biological role for the disordered N-terminal region, which may function as an autoinhibitory domain mediating DENV C interaction with its biological targets. The results fit with our current understanding of DENV C and pep14-23 structure and function, paving the way for similar approaches to understanding disordered proteins and improved peptidomimetics drug development strategies against DENV and similar Flavivirus infections.

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Clinical presentation and laboratory findings for the first autochthonous cases of dengue fever in Madeira island, Portugal, October 2012

Abstract: Binary file ES_Abstracts_Final_ECDC.txt matches

Cited by 58 publications

References 9 publications

Global Distribution of Aedes aegypti and Aedes albopictus in a Climate Change Scenario of Regional Rivalry

Global Distribution of Aedes aegypti and Aedes albopictus in a Climate Change Scenario of Regional Rivalry

Larvicidal Activity againstAedes Aegyptiof Foeniculum Vulgare Essential Oils from Portugal and Cape Verde

Understanding Dengue Virus Capsid Protein Disordered N-Terminus and pep14-23-Based Inhibition

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